期刊
EXPERT REVIEW OF ANTICANCER THERAPY
卷 14, 期 8, 页码 947-954出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14737140.2014.911092
关键词
DNA breakage; epigenetic gene expression changes; food intake; genome instabilities; Helicobacter pylori; inflammations; intestinal-type gastric cancers; virulence factors
类别
资金
- Tokyo Biochemical Foundation
- Office of Research and Development Medical Research Service Department of Veterans Affairs, Public Health Service [DK062813, DK56338]
Gastric carcinoma is an inflammation-related cancer caused by long-term infection with the human bacterial pathogen, Helicobacter pylori. The pattern of acute-on-chronic inflammation causes progressive mucosal damage which may result in atrophy with metaplastic epithelia and eventually gastric cancer. Recently, it has been recognized that H. pylori can also cause genetic instability such as double-stranded DNA breaks and can produce gene activation and silencing via epigenetic pathways. As genetic instability is the hallmark of cancer, we highlight recent progress in understanding the gastric carcinogenesis in relation to H. pylori-related inflammation, H. pylori-induced double-stranded DNA breakage and aberrant gene expression as well as the mechanisms and role of H. pylori-associated epigenetic change in gene expression.
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