期刊
EXPERT REVIEW OF ANTICANCER THERAPY
卷 14, 期 5, 页码 511-521出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14737140.2014.883922
关键词
Abraxane; algorithm; chemotherapy; tumor; response; breast cancer; metastatic
类别
资金
- Celgene International Sarl.
Nab-paclitaxel (Abraxane((R))) is an albumin-bound form of paclitaxel that utilizes the natural properties of albumin to improve paclitaxel delivery to the tumor. It is licensed for use in metastatic breast cancer (MBC) at a dose of 260 mg/m(2) Q3W based on its superior therapeutic index versus conventional paclitaxel 175 mg/m(2) Q3W demonstrated in a Phase III study. In a post-hoc analysis, nab-paclitaxel treatment was associated with rapid and dramatic tumor responses in patients with poor prognostic factors (visceral dominant disease, >= 3 metastatic lesions), suggesting it may be a preferred treatment for these patients. Moreover, significant efficacy has been seen with nab-paclitaxel 100 and 150 mg/m(2) QW 3/4, suggesting it may be possible to tailor use of this agent in the future.
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