期刊
EXPERT REVIEW OF ANTICANCER THERAPY
卷 10, 期 8, 页码 1255-1263出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERA.10.99
关键词
aromatase inhibitors; cross-talk; estrogen receptor; HER2; lapatinib; resistance; trastuzumab
类别
资金
- Universite Libre De Bruxelles (ULB)
Approximately 50% of HER2-positive breast cancers express estrogen receptor (ER) and these tumors are characterized by short-lived responses to hormonal agents. Preclinical models have shown that dual targeting of ER and HER2 could reverse and delay the development of drug resistance. Two studies (TAnDEM & EGF3008) have recently been published addressing the combined use of an aromatase inhibitor (AI) and an anti-HER2-targeted agent. Both studies showed that the combined approach is associated with improvement in response rate and progression-free survival compared with an AI alone with an acceptable toxicity profile. These results would indeed extend the treatment options for patients with ER/HER2-positive metastatic breast cancer. In this article, we discuss how the improved understanding of the complex cross-talk between ER and HER2 has resulted in better clinical outcomes. We analyze clinical evidence regarding the combined use of AIs and anti-HER2-targeted agents. We also touch on possible mechanisms of resistance and ways to improve research in this field.
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