期刊
EXPERT REVIEW OF ANTICANCER THERAPY
卷 9, 期 10, 页码 1487-1497出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERA.09.107
关键词
cellular origin; molecular alterations; mouse models; pancreatic cancer; preneoplastic lesions
类别
As with many human malignancies, pancreatic cancer is a complex genetic disorder. Several thousand disease-associated alterations on the DNA, mRNA, miRNA and protein levels have been reported to date. Some of these alterations, including a number of gatekeeper mutations, which are of pre-eminent importance for the onset and progression of the disease, have been extensively studied in primary tissues, in vitro experiments and transgenic mouse models. For the vast majority of alterations, however, data about the functional significance are lacking. The situation is complicated by the fact that no certainty exists concerning the identity of the cells that originally undergo malignant transformation nor about the precise nature and fate of premalignant lesions that are observed in pancreatic tissues.
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