期刊
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
卷 12, 期 10, 页码 1171-1178出版社
EXPERT REVIEWS
DOI: 10.1586/14787210.2014.948847
关键词
adenovirus; BK virus; Brincidofovir; CMX001; cytomegalovirus; dsDNA virus; JC virus; molluscum; orthopoxvirus; vaccinia virus
资金
- Chimerix
CMX001 (hexadecyloxypropyl-cidofovir, Brincidofovir) is a broad spectrum, lipid conjugate of cidofovir that is converted intracellularly into the active antiviral, cidofovir diphosphate. The lipid conjugation results in oral bioavailability, higher intracellular concentrations of active drug, lower plasma concentrations of cidofovir and increased antiviral potency against dsDNA viruses.
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