期刊
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
卷 10, 期 5, 页码 563-572出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERI.12.37
关键词
co-infection; GBV-C; HCV; HIV
资金
- HW and J Hector foundation
- NIH [R21 AI081564]
GB virus C (GBV-C) is a member of the Flaviviridae family and the most closely related human virus to HCV. However, GBV-C does not replicate in hepatocytes, but rather in lymphocytes. GBV-C has a worldwide distribution and is transmitted sexually, parenterally and through mother-to-child transmission. Thus, co-infection with HCV and HIV is common. Until now, no human disease has been associated with GBV-C infection. However, there are several reports of a beneficial effect of GBV-C on HIV disease progression in vivo. Different mechanisms to explain these observations have been proposed, including modification of antiviral cytokine production, HIV co-receptor expression, direct inhibition of HIV-1 entry, T-cell activation and Fas-mediated apoptosis. Further understanding of these mechanisms may open new strategies for the treatment of HIV/AIDS.
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