期刊
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
卷 9, 期 1, 页码 49-59出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERI.10.142
关键词
arenavirus; hemorrhagic fever; hemorrhagic shock syndrome; immunosuppression; Junin virus; Lassa virus; vascular endothelium; viral pathogenesis
资金
- Swiss National Science Foundation [3100A0-120250/1]
- Prix Leenaards pour la promotion de la recherche scientifique
- Foundation Vontobel
Viral hemorrhagic fevers (VHFs) caused by arenaviruses belong to the most devastating emerging human diseases and represent serious public health problems. Arenavirus VHFs in humans are acute diseases characterized by fever and, in severe cases, different degrees of hemorrhages associated with a shock syndrome in the terminal stage. Over the past years, much has been learned about the pathogenesis of arenaviruses at the cellular level, in particular their ability to subvert the host cell's innate antiviral defenses. Clinical studies and novel animal models have provided important new information about the interaction of hemorrhagic arenaviruses with the host's adaptive immune system, in particular virus-induced immunosuppression, and have provided the first hints towards an understanding of the terminal hemorrhagic shock syndrome. The scope of this article is to review our current knowledge on arenavirus VHF pathogenesis with an emphasis on recent developments.
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