期刊
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
卷 6, 期 2, 页码 201-208出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14787210.6.2.201
关键词
biofilm; extracellular matrix; inflammation; mucosal tissue
资金
- NCRR NIH HHS [M01 RR006192-155326, M01 RR006192] Funding Source: Medline
- NIDCR NIH HHS [R01 DE13986, R01 DE013986, R01 DE013986-07A1] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR006192] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE013986] Funding Source: NIH RePORTER
Living-tissue biofilms remained unrecognized until very recently, mainly as a result of traditional microbial sampling techniques or histologic processing, which disrupt the spatial organization of the tissue microorganisms. Thus, the biofilm nature of certain mucosal infections was frequently unintentionally missed or disregarded. To a large extent, the study of human tissue biofilms is still in its infancy. However, with the advent of newer methodologies, such as fluorescent in situ hybridization and encloscopic confocal laser scanning microscopy, which combine the identification of microbes with in situ, direct visualization of their relationships with each other and with their substratum, mucosal tissue biofilms are becoming easier to study and, thus, their role in human infections is becoming more apparent. This review summarizes the challenges in the study of tissue biofilms, proposes two inflammation-centered - albeit opposite - pathogenetic models of mucosal tissue biofilm infections and suggests directions for future research and novel therapeutic approaches.
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