期刊
EXPERT OPINION ON THERAPEUTIC TARGETS
卷 19, 期 1, 页码 97-112出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728222.2014.959495
关键词
angiogenesis; breast cancer; c-Src; EGFR; exosomes; glioblastoma; glioma; integrin; invasion; melanoma; melanoma differentiation-associated gene-9; metastasis; PDZ; small cell lung carcinoma; syndecan binding protein; syntenin; urothelial cell carcinoma; uveal melanoma
资金
- DoD [W81XWH-10-PCRP-SIDA]
- Samuel Waxman Cancer Research Foundation
- National Foundation for Cancer Research
- [P01 CA104177]
- [R01 CA134721]
- [R01 CA138540]
- [R01 CA168517]
Introduction: Melanoma differentiation-associated gene - 9 (MDA-9)/Syntenin has become an increasingly popular focus for investigation in numerous cancertypes. Originally implicated in melanoma metastasis, it has diverse cellular roles and is consistently identified as a regulator of tumor invasion and angiogenesis. As a potential target for inhibiting some of the most lethal aspects of cancer progression, further insight into the function of MDA-9/Syntenin is mandatory. Areas covered: Recent literature and seminal articles were reviewed to summarize the latest collective understanding of MDA-9/Syntenin's role in normal and cancerous settings. Insights into its participation in developmental processes are included, as is the functional significance of the N- and C-terminals and PDZ domains of MDA-9/Syntenin. Current reports highlight the clinical significance of MDA-9/Syntenin expression level in a variety of cancers, often correlating directly with reduced patient survival. Also presented are assessments of roles of MDA-9/Syntenin in cancer progression as well as its functions as an intracellular adapter molecule. Expert opinion: Multiple studies demonstrate the importance of MDA-9/Syntenin in tumor invasion and progression. Through the use of novel drug design approaches, this protein may provide a worthwhile therapeutic target. As many conventional therapies do not address, or even enhance, tumor invasion, an anti-invasive approach would be a worthwhile addition in cancer therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据