期刊
EXPERT OPINION ON THERAPEUTIC TARGETS
卷 15, 期 4, 页码 401-420出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728222.2011.553609
关键词
adiponectin; ghrelin; insulin; leptin; neuropeptide Y; obesity; type 2 diabetes mellitus
资金
- Hellenic Atherosclerosis Society
Areas covered: The present review considers: i) the role of leptin, adiponectin, ghrelin and NPY in patients with T2DM, and, ii) the effect of insulin as well as oral hypoglycemic, antihypertensive, hypolipidemic, antiobesity and antiplatelet agents on these peptides in patients with T2DM. Expert opinion: Patients with T2DM have either lower or similar leptin levels, decreased adiponectin and ghrelin levels, and increased NPY circulating levels compared with nondiabetic controls. Treatment with insulin, oral hypoglycemic, antihypertensive, hypolipidemic, antiobesity and antiplatelet drugs may influence the levels of these peptides. It is not widely appreciated that several drugs commonly administered to patients with T2DM can influence adipokine levels. The clinical relevance of these effects needs to be evaluated.
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