Neurobiological aspects of Alzheimer's disease

Areas covered: The various neurobiological events associated with development of AD and the multiple treatment approaches for combating this disorder. Expert opinion: AD is a complex multifactorial disorder and thus a single target or pathogenic pathway is unlikely to be identified. Developing therapeutic interventions demands a greater understanding of the processes and the differential involvement of the various mediators. Effective therapeutics are urgently needed, and it is hoped that anti-amyloid strategies will offer a significant step towards a causal therapy.