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GENES & DEVELOPMENT (2010)
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MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
Li Lu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
c-Abl phosphorylation of Delta Np63 alpha is critical for cell viability
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CELL DEATH & DISEASE (2010)
JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis
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CELL DEATH & DISEASE (2010)
Yes-Associated Protein Is an Independent Prognostic Marker in Hepatocellular Carcinoma
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CANCER (2009)
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CANCER CELL (2009)
Connective Tissue Growth Factor Confers Drug Resistance in Breast Cancer through Concomitant Up-regulation of Bcl-xL and cIAP1
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CANCER RESEARCH (2009)
Transcriptional Output of the Salvador/Warts/Hippo Pathway Is Controlled in Distinct Fashions in Drosophila melanogaster and Mammalian Cell Lines
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CANCER RESEARCH (2009)
Both TEAD-Binding and WW Domains Are Required for the Growth Stimulation and Oncogenic Transformation Activity of Yes-Associated Protein
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CANCER RESEARCH (2009)
Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc
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GENES & DEVELOPMENT (2009)
YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation
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GENES & DEVELOPMENT (2009)
Nuclear localization and pro-apoptotic signaling of YAP2 require intact PDZ-binding motif
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Identification of Fat4 as a candidate tumor suppressor gene in breast cancers
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TEADs Mediate Nuclear Retention of TAZ to Promote Oncogenic Transformation
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TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition
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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
被撤回的出版物: Phase II Study of the Anti-Insulin-Like Growth Factor Type 1 Receptor Antibody CP-751,871 in Combination With Paclitaxel and Carboplatin in Previously Untreated, Locally Advanced, or Metastatic Non-Small-Cell Lung Cancer (Retracted article. See vol. 30, pg. 4179, 2012)
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JOURNAL OF CLINICAL ONCOLOGY (2009)
Safety, Pharmacokinetics, and Pharmacodynamics of the Insulin-Like Growth Factor Type 1 Receptor Inhibitor Figitumumab (CP-751,871) in Combination with Paclitaxel and Carboplatin
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JOURNAL OF THORACIC ONCOLOGY (2009)
Neurofibromatosis type 2
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LANCET (2009)
miR-372 regulates cell cycle and apoptosis of ags human gastric cancer cell line through direct regulation of LATS2
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MOLECULES AND CELLS (2009)
YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway
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NATURE CELL BIOLOGY (2009)
EGR-1 forms a complex with YAP-1 and upregulates Bax expression in irradiated prostate carcinoma cells
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ONCOGENE (2009)
In vivo analysis of Yorkie phosphorylation sites
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ONCOGENE (2009)
RASSF2 associates with and stabilizes the proapoptotic kinase MST2
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ONCOGENE (2009)
Hippo Pathway-Dependent and -Independent Roles of RASSF6
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SCIENCE SIGNALING (2009)
Kpm/Lats2 is linked to chemosensitivity of leukemic cells through the stabilization of p73
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BLOOD (2008)
Merlin is apotent inhibitor of glioma growth
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CANCER RESEARCH (2008)
Down-regulation of mammalian sterile 20-like kinase 1 by heat shock protein 70 mediates cisplatin resistance in prostate cancer cells
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CANCER RESEARCH (2008)
AXL is a potential target for therapeutic intervention in breast cancer progression
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CANCER RESEARCH (2008)
Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway
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CANCER RESEARCH (2008)
Yes-associated protein (YAP) functions as a tumor suppressor in breast
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CELL DEATH AND DIFFERENTIATION (2008)
SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila
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CURRENT BIOLOGY (2008)
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation
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CURRENT BIOLOGY (2008)
Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling
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DEVELOPMENT (2008)
The TEAD/TEF family protein scalloped mediates transcriptional output of the hippo growth-regulatory pathway
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DEVELOPMENTAL CELL (2008)
A crucial role of WW45 in developing epithelial tissues in the mouse
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EMBO JOURNAL (2008)
YAP regulates neural progenitor cell number via the TEA domain transcription factor
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TEAD mediates YAP-dependent gene induction and growth control
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Autocrine insulin-like growth factor-II stimulation of tumor cell migration is a progression step in human hepatocarcinogenesis
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Expression of Yes-associated protein in common solid tumors
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Mst2 and lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway
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The emerging role of the insulin-like growth factor pathway as a therapeutic target in cancer
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ONCOLOGIST (2008)
Tumor suppressor LATS1 is a negative regulator of oncogene YAP
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Yes-Associated Protein (YAP) is a critical mediator of c-Jun-dependent apoptosis
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CELL DEATH AND DIFFERENTIATION (2008)
Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through β-catenin-T-cell factor/Lef signaling
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YAP1 increases organ size and expands undifferentiated progenitor cells
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CURRENT BIOLOGY (2007)
Selective Raf inhibition in cancer therapy
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EXPERT OPINION ON THERAPEUTIC TARGETS (2007)
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
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GENES & DEVELOPMENT (2007)
The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1
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EMBO JOURNAL (2007)
Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma
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MOLECULAR CARCINOGENESIS (2007)
Elucidation of a universal size-control mechanism in Drosophila and mammals
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CELL (2007)
RASSRA elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the P73 tumor suppressor protein
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MOLECULAR CELL (2007)
Filling out the Hippo pathway
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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network
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CURRENT BIOLOGY (2007)
Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinorna cells expressing AXL
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CANCER RESEARCH (2007)
Prognostic significance of mammalian sterile20-like kinase 1 in colorectal cancer
Parham Minoo et al.
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Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac
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CANCER RESEARCH (2007)
Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity
Joshua P. Cantor et al.
INTERNATIONAL JOURNAL OF CANCER (2007)
The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network
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NATURE REVIEWS CANCER (2007)
The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73
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CELL DEATH AND DIFFERENTIATION (2007)
The Drosophila RASSF homolog antagonizes the hippo pathway
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CURRENT BIOLOGY (2006)
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NEUROSCIENCE RESEARCH (2006)
Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway
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CURRENT BIOLOGY (2006)
The tumor-suppressor gene fat controls tissue growth upstream of expanded in the Hippo signaling pathway
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CURRENT BIOLOGY (2006)
The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size
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CURRENT BIOLOGY (2006)
The bantam microRNA is a target of the hippo tumor-suppressor pathway
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CURRENT BIOLOGY (2006)
Delineation of a Fat tumor suppressor pathway
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NATURE GENETICS (2006)
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation
Bernard A. Callus et al.
FEBS JOURNAL (2006)
The hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila
Barry J. Thompson et al.
CELL (2006)
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon
Michael Overholtzer et al.
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Effect of blocking IGF-I receptor on growth of human hepatocellular carcinoma cells
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WORLD JOURNAL OF GASTROENTEROLOGY (2006)
Dachs:: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila
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DEVELOPMENT (2006)
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
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CELL (2006)
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CANCER RESEARCH (2006)
Role of the tumor suppressor RASSF1A in Mst1-medated apoptosis
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CANCER RESEARCH (2006)
Phase I study of liposome-encapsulated c-raf antisense oligodeoxyribonucleotide infusion in combination with radiation therapy in patients with advanced malignancies
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CLINICAL CANCER RESEARCH (2006)
Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73
M Hoshino et al.
JOURNAL OF CELL BIOLOGY (2006)
Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis
Nadja Dornhoefer et al.
CANCER RESEARCH (2006)
The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis
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NATURE CELL BIOLOGY (2006)
Membrane organization and tumorigenesis - the NF2 tumor suppressor, Merlin
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GENES & DEVELOPMENT (2005)
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation
JH Hong et al.
SCIENCE (2005)
The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP
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CELL (2005)
The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA damage
S Strano et al.
MOLECULAR CELL (2005)
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
EH Chan et al.
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CELL (2005)
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CELL CYCLE (2005)
Inhibitors of the mammalian target of rapamycin
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EXPERT OPINION ON INVESTIGATIONAL DRUGS (2005)
Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871
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CLINICAL CANCER RESEARCH (2005)
Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers
Y Takahashi et al.
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Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription
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EMBO JOURNAL (2004)
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BIOCHEMICAL PHARMACOLOGY (2004)
Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling
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DEVELOPMENT (2004)
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SCIENCE (2004)
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CLINICAL CANCER RESEARCH (2004)
Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway
RS Udan et al.
NATURE CELL BIOLOGY (2003)
The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila
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NATURE CELL BIOLOGY (2003)
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ONCOGENE (2003)
WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis
KF Harvey et al.
CELL (2003)
hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts
S Wu et al.
CELL (2003)
Lats2, a putative tumor suppressor, inhibits G1/S transition
YF Li et al.
ONCOGENE (2003)
Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis
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MOLECULAR CELL (2003)
Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila
M Kango-Singh et al.
DEVELOPMENT (2002)
Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma
M Hisaoka et al.
LABORATORY INVESTIGATION (2002)
salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines
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CELL (2002)
LATS1 tumor suppressor regulates G2/M transition and apoptosis
H Xia et al.
ONCOGENE (2002)
Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G2/M arrest or apoptosis
XL Yang et al.
ONCOGENE (2001)
MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation
KK Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm
A Vassilev et al.
GENES & DEVELOPMENT (2001)
Physical interaction with Yes-associated protein enhances p73 transcriptional activity
S Strano et al.
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EMBO JOURNAL (2000)
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