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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
c-Abl phosphorylation of Delta Np63 alpha is critical for cell viability
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CELL DEATH & DISEASE (2010)
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CANCER (2009)
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Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc
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YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation
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TEADs Mediate Nuclear Retention of TAZ to Promote Oncogenic Transformation
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JOURNAL OF CLINICAL ONCOLOGY (2009)
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LANCET (2009)
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YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway
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EGR-1 forms a complex with YAP-1 and upregulates Bax expression in irradiated prostate carcinoma cells
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ONCOGENE (2009)
RASSF2 associates with and stabilizes the proapoptotic kinase MST2
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ONCOGENE (2009)
Hippo Pathway-Dependent and -Independent Roles of RASSF6
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SCIENCE SIGNALING (2009)
Kpm/Lats2 is linked to chemosensitivity of leukemic cells through the stabilization of p73
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BLOOD (2008)
Merlin is apotent inhibitor of glioma growth
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Down-regulation of mammalian sterile 20-like kinase 1 by heat shock protein 70 mediates cisplatin resistance in prostate cancer cells
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Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway
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Yes-associated protein (YAP) functions as a tumor suppressor in breast
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CURRENT BIOLOGY (2008)
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation
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Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling
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The TEAD/TEF family protein scalloped mediates transcriptional output of the hippo growth-regulatory pathway
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TEAD mediates YAP-dependent gene induction and growth control
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TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Yes-Associated Protein (YAP) is a critical mediator of c-Jun-dependent apoptosis
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Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through β-catenin-T-cell factor/Lef signaling
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YAP1 increases organ size and expands undifferentiated progenitor cells
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Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
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GENES & DEVELOPMENT (2007)
The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1
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Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma
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CELL (2007)
RASSRA elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the P73 tumor suppressor protein
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MOLECULAR CELL (2007)
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RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network
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Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac
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Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity
Joshua P. Cantor et al.
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The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73
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CELL DEATH AND DIFFERENTIATION (2007)
The Drosophila RASSF homolog antagonizes the hippo pathway
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CURRENT BIOLOGY (2006)
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Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway
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The tumor-suppressor gene fat controls tissue growth upstream of expanded in the Hippo signaling pathway
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CURRENT BIOLOGY (2006)
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CURRENT BIOLOGY (2006)
Delineation of a Fat tumor suppressor pathway
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Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation
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The hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila
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CELL (2006)
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Role of the tumor suppressor RASSF1A in Mst1-medated apoptosis
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Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73
M Hoshino et al.
JOURNAL OF CELL BIOLOGY (2006)
Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis
Nadja Dornhoefer et al.
CANCER RESEARCH (2006)
The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis
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NATURE CELL BIOLOGY (2006)
Membrane organization and tumorigenesis - the NF2 tumor suppressor, Merlin
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The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP
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CELL (2005)
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S Strano et al.
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The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
EH Chan et al.
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CELL (2005)
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E O'Neill et al.
CELL CYCLE (2005)
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EXPERT OPINION ON INVESTIGATIONAL DRUGS (2005)
Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871
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CLINICAL CANCER RESEARCH (2005)
Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers
Y Takahashi et al.
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Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription
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EMBO JOURNAL (2004)
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E Cho et al.
DEVELOPMENT (2004)
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CLINICAL CANCER RESEARCH (2004)
Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway
RS Udan et al.
NATURE CELL BIOLOGY (2003)
The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila
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NATURE CELL BIOLOGY (2003)
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ONCOGENE (2003)
WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis
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CELL (2003)
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S Wu et al.
CELL (2003)
Lats2, a putative tumor suppressor, inhibits G1/S transition
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DEVELOPMENT (2002)
Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma
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salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines
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CELL (2002)
LATS1 tumor suppressor regulates G2/M transition and apoptosis
H Xia et al.
ONCOGENE (2002)
Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G2/M arrest or apoptosis
XL Yang et al.
ONCOGENE (2001)
MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation
KK Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm
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Physical interaction with Yes-associated protein enhances p73 transcriptional activity
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
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EMBO JOURNAL (2000)