期刊
EXPERT OPINION ON THERAPEUTIC TARGETS
卷 14, 期 9, 页码 951-962出版社
INFORMA HEALTHCARE
DOI: 10.1517/14728222.2010.510136
关键词
AKT; ATRA; chromosomal imbalance; differentiation; microRNA; miR-184; miR-34a; MYCN; neuroblastoma
资金
- Science Foundation Ireland [07/IN, 1/B1776]
- Children's Medical and Research Foundation, Cancer Research Ireland
- US National Institutes of Health [5R01CA127496]
- NATIONAL CANCER INSTITUTE [R01CA127496] Funding Source: NIH RePORTER
Importance of the field: Neuroblastomas arise from precursor cells of the sympathetic nervous system and are noted for highly heterogeneous clinical behavior. These tumors currently account for similar to 15% of all childhood cancer related deaths in spite of intensive multimodal chemotherapy and are a major problem in pediatric oncology. The identification of novel therapeutic targets is urgently required to reduce patient morbidity. Areas covered in this review: The purpose of this article is to review and synthesize all of the rapidly expanding evidence for the contribution of microRNAs (miRNAs) in neuroblastoma aggressive disease pathogenesis, along with the prospect of using small RNAs as therapeutics. What the reader will gain: The reader will obtain insight on the miRNAs that are dysregulated in neuroblastoma along with potential therapeutic strategies and the most promising targets. Take home message: A number of miRNAs which are associated with aggressive disease pathogenesis in neuroblastoma patients have been demonstrated to contribute in major ways to cell proliferation rates, apoptosis, differentiation, invasiveness and tumor growth in vitro and in vivo. Directly or indirectly interfering with the function of these miRNAs may prove to be an important and novel form of therapy.
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