相关参考文献
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John W. M. Creemers et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2008)
VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5
Dorota Szumska et al.
GENES & DEVELOPMENT (2008)
Proprotein convertase Subtilisin/Kexin type 9 (PCSK9): Hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration
Ahmed Zaid et al.
HEPATOLOGY (2008)
Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells
Nathalie Scamuffa et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Hormonal regulation of proprotein convertase subtilisin/kexin type 5 expression during ovarian follicle development in the rat
Jeong-A Bae et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2008)
Common nonsynonymous variants in PCSK1 confer risk of obesity
Michael Benzinou et al.
NATURE GENETICS (2008)
In vivo functions of the proprotein convertase PC5/6 during mouse development:: Gdf11 is a likely substrate
Rachid Essalmani et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Cell-surface processing of extracellular human immunodeficiency virus type I Vpr by proprotein convertases
Yong Xiao et al.
VIROLOGY (2008)
The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates
Gaetan Mayer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: Role of tissue inhibitors of metalloproteinase-1
Marion Lapierre et al.
CANCER RESEARCH (2007)
Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3
I. Sadaf Farooqi et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2007)
Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens
Sergey A. Shiryaev et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The proprotein convertases are potential targets in the treatment of dyslipidemia
Nabil G. Seidah et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2007)
Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis
Yue-Wei Qian et al.
JOURNAL OF LIPID RESEARCH (2007)
Pro-protein convertases (PCs) other than PC6 are not tightly regulated for implantation in the human endometrium
C. Freyer et al.
REPRODUCTION (2007)
Molecular biology of PCSK9: its role in LDL metabolism
Jay D. Horton et al.
TRENDS IN BIOCHEMICAL SCIENCES (2007)
Short polybasic peptide sequences are potent inhibitors of PC5/6 and PC7: Use of positional scanning-synthetic peptide combinatorial libraries as a tool for the optimization of inhibitory sequences
Martin Fugere et al.
MOLECULAR PHARMACOLOGY (2007)
The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A-Functional consequences of natural mutations and post-translational modifications
Suzanne Benjannet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Proprotein convertases:: lessons from knockouts
Nathalie Scamuffa et al.
FASEB JOURNAL (2006)
Sperm from mice genetically deficient for the PCSK4 proteinase exhibit accelerated capacitation, precocious acrosome reaction, reduced binding to egg zona pellucida, and impaired fertilizing ability
C Gyamera-Acheampong et al.
BIOLOGY OF REPRODUCTION (2006)
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
JC Cohen et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Cleavage of the papillomavirus minor capsid protein, L2, at a furin consensus site is necessary for infection
RM Richards et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse
R Essalmani et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Modulation and redistribution of proteinase inhibitor 8 (Serpinb8) during kidney regeneration
A Gillard et al.
AMERICAN JOURNAL OF NEPHROLOGY (2006)
Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote
Zhenze Zhao et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2006)
Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases -: art. no. 149
GN Tzimas et al.
BMC CANCER (2005)
Proprotein convertases furin and PC5: targeting atherosclerosis and restenosis at multiple levels
P Stawowy et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2005)
Inhibitors of proprotein convertases
A Basak
JOURNAL OF MOLECULAR MEDICINE-JMM (2005)
Proprotein convertases: Master switches in the regulation of tumor growth and progression
DE Bassi et al.
MOLECULAR CARCINOGENESIS (2005)
The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases
N Nour et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression
DE Bassi et al.
CANCER RESEARCH (2005)
Role of pro-IGF-II processing by proprotein convertase 4 in human placental development
Q Qiu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Cutting back on pro-protein convertases:: the latest approaches to pharmacological inhibition
M Fugère et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2005)
Inhibiting uterine PC6 blocks embryo implantation: An obligatory role for a proprotein convertase in fertility
GY Nie et al.
BIOLOGY OF REPRODUCTION (2005)
Requirement for proprotein convertase 5/6 during decidualization of human endometrial stromal cells in vitro
H Okada et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)
Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus
E Bergeron et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Development of protein-based inhibitors of the proprotein of convertase SKI-1/S1P - Processing of SREBP-2, ATF6, and a viral glycoprotein
P Pullikotil et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Limited redundancy of the proprotein convertase furin in mouse liver
AJM Roebroek et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpin
MJ Richer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
NARC-1/PCSK9 and its natural mutants -: Zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol
S Benjannet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Polyarginine inhibits gp160 processing by furin and suppresses productive human immunodeficiency virus type 1 infection
KV Kibler et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo
MS Sarac et al.
INFECTION AND IMMUNITY (2004)
Curbing activation: proprotein convertases in homeostasis and pathology
NA Taylor et al.
FASEB JOURNAL (2003)
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity
S Henrich et al.
NATURE STRUCTURAL BIOLOGY (2003)
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
M Abifadel et al.
NATURE GENETICS (2003)
Furin processing and proteolytic activation of Semliki Forest virus
XY Zhang et al.
JOURNAL OF VIROLOGY (2003)
The cystatin-related epididymal spermatogenic protein inhibits the serine protease prohormone convertase 2
GA Cornwall et al.
ENDOCRINOLOGY (2003)
The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1):: Liver regeneration and neuronal differentiation
NG Seidah et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo
MS Sarac et al.
INFECTION AND IMMUNITY (2002)
Furin at the cutting edge: From protein traffic to embryogenesis and disease
G Thomas
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
Proprotein convertases in tumor progression and malignancy -: Novel targets in cancer therapy
AM Khatib et al.
AMERICAN JOURNAL OF PATHOLOGY (2002)
The ordered and compartment-specific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation
ED Anderson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Malignant conversion of non-tumorigenic murine skin keratinocytes overexpressing PACE4
H Mahloogi et al.
CARCINOGENESIS (2002)
Functional characterization of proSAAS - Similarities and differences with 7B2
Y Fortenberry et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene
J Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins - Evolution, mechanism of inhibition, novel functions, and a revised nomenclature
GA Silverman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The testicular germ-cell protease PC4 is also expressed in macrophage-like cells of the ovary
H Tadros et al.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2001)
Distribution of proSAAS-derived peptides in rat neuroendocrine tissues
Y Feng et al.
NEUROSCIENCE (2001)
Polyarginines are potent furin inhibitors
A Cameron et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)