期刊
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
卷 78, 期 11, 页码 635-641出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1016/j.jcma.2015.07.008
关键词
age-related macular degeneration; choroidal neovascularization; nanotechnology; target therapy; vascular endothelial growth factor
Nanoparticles combined with cells, drugs, and specially designed genes provide improved therapeutic efficacy in studies and clinical setting, demonstrating a new era of treatment strategy, especially in retinal diseases. Nanotechnology-based drugs can provide an essential platform for sustaining, releasing and a specific targeting design to treat retinal diseases. Poly-lactic-co-glycolic acid is the most widely used biocompatible and biodegradable polymer approved by the Food and Drug Administration. Many studies have attempted to develop special devices for delivering small-molecule drugs, proteins, and other macromolecules consistently and slowly. In this article, we first review current progress in the treatment of age-related macular degeneration. Then, we discuss the function of vascular endothelial growth factor (VEGF) and the pharmacological effects of anti-VEGF-A antibodies and soluble or modified VEGF receptors. Lastly, we summarize the combination of anti-angiogenic therapy and nanomedicines, and review current potential targeting therapy in age-related macular degeneration. Copyright (C) 2015 Elsevier Taiwan LLC and the Chinese Medical Association. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据