相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Identification of Novel Synthetic Toll-like Receptor 2 Agonists by High Throughput Screening
Yue Guan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Taro Kawai et al.
NATURE IMMUNOLOGY (2010)
Targeting Toll-like receptors: emerging therapeutics?
Elizabeth J. Hennessy et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Molecular Modeling-Based Evaluation of hTLR10 and Identification of Potential Ligands in Toll-Like Receptor Signaling
Rajiv Gandhi Govindaraj et al.
PLOS ONE (2010)
Structure-Function Relationship of Cytoplasmic and Nuclear IκB Proteins: An In Silico Analysis
Balachandran Manavalan et al.
PLOS ONE (2010)
Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and αDEC-CSP in non human primates
Kavita Tewari et al.
VACCINE (2010)
Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists
Joerg Vollmer et al.
ADVANCED DRUG DELIVERY REVIEWS (2009)
A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis
Ryan Ungaro et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2009)
Drugs targeting toll-like receptors
Jayalakshmi Krishnan et al.
ARCHIVES OF PHARMACAL RESEARCH (2009)
Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma
Jonathan W. Friedberg et al.
BRITISH JOURNAL OF HAEMATOLOGY (2009)
Emerging drugs for the treatment of ulcerative colitis
Luca Pastorelli et al.
EXPERT OPINION ON EMERGING DRUGS (2009)
Vaccine adjuvants: scientific challenges and strategic initiatives
Ali M. Harandi et al.
EXPERT REVIEW OF VACCINES (2009)
Identification and characterization of oligonucleotides that inhibit Toll-like receptor 2-associated immune responses
Yi-Chung Chang et al.
FASEB JOURNAL (2009)
The potential use of toll-like receptor (TLR) agonists and antagonists as prophylactic and/or therapeutic agents
Amani Makkouk et al.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2009)
Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant
M. Paula Longhi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
Morphological study on Mycobacterium bovis BCG Tokyo 172 cell wall skeleton (SMP-105)
Yuko Uenishi et al.
JOURNAL OF MICROBIOLOGICAL METHODS (2009)
Characterization of bovine Toll-like receptor 8: Ligand specificity, signaling essential sites and dimerization
Jianzhong Zhu et al.
MOLECULAR IMMUNOLOGY (2009)
Results of a phase IIa clinical trial of an anti-inflammatory molecule, chaperonin 10, in multiple sclerosis
S. A. Broadley et al.
MULTIPLE SCLEROSIS (2009)
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
Beom Seok Park et al.
NATURE (2009)
Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer
Luke A. J. O'Neill et al.
PHARMACOLOGICAL REVIEWS (2009)
Toll-like receptor 2 dependent immunogenicity of glycoconjugate vaccines containing chemically derived zwitterionic polysaccharides
Simona Gallorini et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Innate immune sensing and activation of cell surface Toll-like receptors
Richard I. Tapping
SEMINARS IN IMMUNOLOGY (2009)
In vivo and in vitro adjuvant activities of the B subunit of Type IIb heat-labile enterotoxin (LT-IIb-B5) from Escherichia coli
Shuang Liang et al.
VACCINE (2009)
Ampligen: A potential toll-like 3 receptor adjuvant for immunotherapy of cancer
B. Jasani et al.
VACCINE (2009)
Primary Leukocyte Screens for Innate Immune Agonists
Amber Goodchild et al.
JOURNAL OF BIOMOLECULAR SCREENING (2009)
Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids
Xinyan Liu et al.
ATHEROSCLEROSIS (2008)
Paired toll-like receptor agonists enhance vaccine therapy through induction of interleukin-12
Rongxiu Zheng et al.
CANCER RESEARCH (2008)
Activation of Toll-like receptor 2 by a novel preparation of cell wall skeleton from Mycobacterium bovis BCG Tokyo (SMP-105) sufficiently enhances immune responses against tumors
Masashi Murata
CANCER SCIENCE (2008)
Putting endotoxin to work for us: Monophosphoryl lipid A as a safe and effective vaccine adjuvant
C. R. Casella et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
An exploratory study of systemic administration of the Toll-like receptor-7 agonist 852A in patients with refractory metastatic melanoma
Reinhard Dummer et al.
CLINICAL CANCER RESEARCH (2008)
Self-adjuvanting lipopeptide vaccines
Peter M. Moyle et al.
CURRENT MEDICINAL CHEMISTRY (2008)
Bridging innate immunity and myocardial ischemia/reperfusion injury: The search for therapeutic targets
Fatih Arslan et al.
CURRENT PHARMACEUTICAL DESIGN (2008)
The antiviral activity of toll-like receptor 7 and 7/8 agonists
Richard L. Miller et al.
DRUG NEWS & PERSPECTIVES (2008)
Functional diversification of the toll-like receptor gene family
Austin L. Hughes et al.
IMMUNOGENETICS (2008)
TLR4-induced IFN-γ production increases TLR2 sensitivity and drives Gram-negative sepsis in mice
Stephan Spiller et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Toll-like receptor 9 (TLR9) agonists in the treatment of cancer
A. M. Krieg
ONCOGENE (2008)
Toll-like receptors and immune regulation: implications for cancer therapy
R-F Wang et al.
ONCOGENE (2008)
TLR7 and TLR8 as targets in cancer therapy
M. P. Schoen et al.
ONCOGENE (2008)
An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models
Lyudmila G. Burdelya et al.
SCIENCE (2008)
Structural basis of toll-like receptor 3 signaling with double-stranded RNA
Lin Liu et al.
SCIENCE (2008)
Cathepsin K-dependent Toll-like receptor 9 signaling revealed in experimental arthritis
Masataka Asagiri et al.
SCIENCE (2008)
Role of neutrophils in BCG immunotherapy for bladder cancer
Mark P. Simons et al.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2008)
The PorB porin from commensal Neisseria lactamica induces Th1 and Th2 immune responses to ovalbumin in mice and is a potential immune adjuvant
Xiuping Liu et al.
VACCINE (2008)
Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin
James W. Huleatt et al.
VACCINE (2008)
Anti-tumor effect of DNA-based vaccination and dSLIM immunomodulatory molecules in mice with Ph+ acute lymphoblastic leukaemia
Joachim Koechling et al.
VACCINE (2008)
Harmful molecular mechanisms in sepsis
Daniel Rittirsch et al.
NATURE REVIEWS IMMUNOLOGY (2008)
Influence of plasma cholesterol and triglyceride concentrations and eritoran (E5564) micelle size on its plasma pharmacokinetics and Ex vivo activity following single intravenous bolus dose into healthy female rabbits
Kishor M. Wasan et al.
PHARMACEUTICAL RESEARCH (2008)
Immunoadjuvant effects of polyadenylic : polyuridylic acids through TLR3 and TLR7
Takahiro Sugiyama et al.
INTERNATIONAL IMMUNOLOGY (2008)
Treatment of lupus-prone of TLR7 and TLR9 leads to mice with a dual inhibitor reduction of autoantibody production and amelioration of disease symptoms
Franck J. Barrat et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2007)
Synthetic agonists of Toll-like receptors 7, 8 and 9
S. Agrawal et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2007)
Application of β-lactamase enzyme complementation to the high-throughput screening of toll-like receptor signaling inhibitors
Hyun-Ku Lee et al.
MOLECULAR PHARMACOLOGY (2007)
Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
Mi Sun Jin et al.
CELL (2007)
Toll-like receptor signal transduction
Jayalakshmi Krishnan et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2007)
Oral resiquimod in chronic HCV infection: Safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies
Paul J. Pockros et al.
JOURNAL OF HEPATOLOGY (2007)
Pharmacokinetics of 852A, an imidazoquinoline toll-like receptor 7-specific agonist, following intravenous, subcutaneous, and oral administrations in humans
Lester I. Harrison et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2007)
Targeting toll-like receptors for drug development: a summary of commercial approaches
Andrew J. H. Gearing
IMMUNOLOGY AND CELL BIOLOGY (2007)
Pollinex® Quattro Ragweed:: safety evaluation of a new allergy vaccine adjuvanted with monophosphoryl lipid A (MPL®) for the treatment of ragweed pollen allergy
Paul Baldrick et al.
JOURNAL OF APPLIED TOXICOLOGY (2007)
Ibudilast (AV-411): a new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes
Annemarie Ledeboer et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2007)
The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4
Veronica Mata-Haro et al.
SCIENCE (2007)
Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus
Rahul D. Pawar et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2007)
Case-control study of human papillomavirus and oropharyngeal cancer
Gypsyamber D'Souza et al.
NEW ENGLAND JOURNAL OF MEDICINE (2007)
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
Holger Kanzler et al.
NATURE MEDICINE (2007)
Cutting edge: Differential inhibition of TLR signaling pathways by cell-permeable peptides representing BB loops of TLRs
Vladimir Y. Toshchakov et al.
JOURNAL OF IMMUNOLOGY (2007)
A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin
Erica Andersen-Nissen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
A Phase II, double-blind, placebo-controlled, ascending-dose study of eritoran (E5564), a lipid a antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass
Elliott Bennett-Guerrero et al.
ANESTHESIA AND ANALGESIA (2007)
Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors
Kensuke Miyake
SEMINARS IN IMMUNOLOGY (2007)
Current and future drugs targeting one class of innate immunity receptors: the Toll-like receptors
Francois Romagne
DRUG DISCOVERY TODAY (2007)
The innate signaling of dangers and the dangers of innate signaling
Philippe J. Sansonetti
NATURE IMMUNOLOGY (2006)
Systemic lupus erythematosus: all roads lead to type I interferons
Virginia Pascual et al.
CURRENT OPINION IN IMMUNOLOGY (2006)
The radiosensitizing effect of immunoadjuvant OM-174 requires cooperation between immune and tumor cells through interferon-gamma and inducible nitric oxide synthase
Mark De Ridder et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2006)
Cutting edge: Activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides
Keith K. B. Gorden et al.
JOURNAL OF IMMUNOLOGY (2006)
Review - Genomic insights into the immune system of the sea urchin
Jonathan P. Rast et al.
SCIENCE (2006)
Toll-like receptors in systemic autoimmune disease
Ann Marshak-Rothstein
NATURE REVIEWS IMMUNOLOGY (2006)
Strategies for targeting T-cells in allergic diseases and asthma
I. H. Heijink et al.
PHARMACOLOGY & THERAPEUTICS (2006)
Pollinex® Quattro:: a novel and well-tolerated, ultra short-course allergy vaccine
Piyush Patel et al.
EXPERT REVIEW OF VACCINES (2006)
Therapeutic efficacy and safety of chaperonin 10 in patients with rheumatoid arthritis: a double-blind randomised trial
Daina Vanags et al.
LANCET (2006)
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus
Sean R. Christensen et al.
IMMUNITY (2006)
Immunobiology of Toll-like receptors: Emerging trends
Saumya Pandey et al.
IMMUNOLOGY AND CELL BIOLOGY (2006)
The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu
Mohamed L. Salem et al.
VACCINE (2006)
TLR3 can directly trigger apoptosis in human cancer cells
Bruno Salaun et al.
JOURNAL OF IMMUNOLOGY (2006)
A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling
M Ii et al.
MOLECULAR PHARMACOLOGY (2006)
Pathogen recognition and innate immunity
S Akira et al.
CELL (2006)
Activation of anti-hepatitis C virus responses via Toll-like receptor 7
J Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
TLR signaling pathways: Opportunities for activation and blockade in pursuit of therapy
K. Hoebe et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
The glial modulatory drug AV(411) attenuates mechanical allodynia in rat models of neuropathic pain
Annemarie Ledeboer et al.
NEURON GLIA BIOLOGY (2006)
Therapeutic targeting of pattern-recognition receptors
Nima Rezaei
INTERNATIONAL IMMUNOPHARMACOLOGY (2006)
Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8
J Vollmer et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Modulation of atherosclerosis in mice by Toll-like receptor 2
AE Mullick et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Nucleic acids of mammalian origin can act as endogenous ligands for toll-like receptors and may promote systemic lupus erythematosus
FJ Barrat et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Randomized phase IIB trial of BLP25 liposome vaccine in stage IIIB and IV non-small-cell lung cancer
C Butts et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
Crystal structure of human Toll-like receptor 3 (TLR3) ectodomain
J Choe et al.
SCIENCE (2005)
The evolution of vertebrate Toll-like receptors
JC Roach et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Antitumour effect of OM-174 and Cyclophosphamide on murine B16 melanoma in different experimental conditions
C D'Agostini et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2005)
Differential role for TLR3 in respiratory syncytial virus-induced chemokine expression
BD Rudd et al.
JOURNAL OF VIROLOGY (2005)
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
F Heil et al.
SCIENCE (2004)
Flavor decomposition of the sea-quark helicity distributions in the nucleon from semiinclusive deep inelastic scattering -: art. no. 012005
A Airapetian et al.
PHYSICAL REVIEW LETTERS (2004)
Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
T Kawai et al.
NATURE IMMUNOLOGY (2004)
Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors
M Gilliet et al.
ARCHIVES OF DERMATOLOGY (2004)
Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling
K Honda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Bacterial lipopolysaccharide signaling through Toll-like receptor 4 suppresses asthma-like responses via nitric oxide synthase 2 activity
D Rodríguez et al.
JOURNAL OF IMMUNOLOGY (2003)
The Toll-IL-1 receptor adaptor family grows to five members
LAJ O'Neill et al.
TRENDS IN IMMUNOLOGY (2003)
Tissue expression of human toll-like receptors and differential regulation of toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines
KA Zarember et al.
JOURNAL OF IMMUNOLOGY (2002)
A Toll-like receptor recognizes bacterial DNA
H Hemmi et al.
NATURE (2000)
Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: Selective expression of TLR3 in dendritic cells
M Muzio et al.
JOURNAL OF IMMUNOLOGY (2000)
分享论文
