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HIV-1 Tat C-terminus is cleaved by calpain 1: Implication for Tat-mediated neurotoxicity
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2009)
Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
A new epicatechin gallate and calpain inhibitory activity from Orostachys japonicus
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FITOTERAPIA (2009)
Identification of 3-Acetyl-2-aminoquinolin-4-one as a Novel, Nonpeptidic Scaffold for Specific Calpain Inhibitory Activity
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JOURNAL OF MEDICINAL CHEMISTRY (2009)
Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors
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BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Design and synthesis of 4-quinolinone 2-carboxamides as calpain inhibitors
Dong Hyuk Nam et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Synthesis and calpain inhibitory activity of peptidomimetic compounds with constrained amino acids at the P2 position
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Evaluation of a novel calpain inhibitor as a treatment for cataract
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Calpain as a Potential Therapeutic Target in Parkinson's Disease
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CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2008)
Neuroprotection with delayed calpain inhibition after transient forebrain ischemia
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CRITICAL CARE MEDICINE (2008)
Structural basis for the potent calpain inhibitory activity of peptidyl α-ketoacids
Isaac O. Donkor et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Cocrystal structures of primed side-extending α-ketoamide inhibitors reveal novel calpain-inhibitor aromatic interactions
Jin Qian et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Calpain-mediated signaling mechanisms in neuronal injury and neurodegeneration
P. S. Vosler et al.
MOLECULAR NEUROBIOLOGY (2008)
Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
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NATURE (2008)
The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons
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NEUROCHEMISTRY INTERNATIONAL (2008)
The role of calcium-activated protease calpain in experimental retinal pathology
M. Azuma et al.
SURVEY OF OPHTHALMOLOGY (2008)
Studies on calpain inhibitors.: Synthesis of partially reduced isoquinoline-1-thiorte derivatives and conversion to functionalized 1-chloroisoquinolines
Roberto Chicharro et al.
TETRAHEDRON LETTERS (2008)
Comprehensive behavioral phenotyping of calpastatin-knockout mice
Ryuichi Nakajima et al.
Molecular Brain (2008)
Mechanistic role of calpains in postischemic neurodegeneration
Matthew B. Bevers et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2008)
Calpastatin levels affect calpain activation and calpain proteolytic activity in APP transgenic mouse model of Alzheimer's disease
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NEUROCHEMISTRY INTERNATIONAL (2007)
Direct effect of human immunodeficiency virus protease inhibitors on neutrophil function and apoptosis via calpain inhibition
Nurit Hadad et al.
CLINICAL AND VACCINE IMMUNOLOGY (2007)
Evidence for calpain-mediated androgen receptor cleavage as a mechanism for androgen independence
Stephen J. Libertini et al.
CANCER RESEARCH (2007)
Investigation into the P3 binding domain of m-calpain using photoswitchable diazo- and triazene-dipeptide aldehydes:: New anticataract agents
Andrew D. Abell et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury
Jinglu Ai et al.
JOURNAL OF NEUROTRAUMA (2007)
A novel dual inhibitor of calpains and lipid peroxidation (BN82270) rescues the cochlea from sound trauma
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NEUROPHARMACOLOGY (2007)
Calpain-mediated regulation of platelet signaling pathways
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CURRENT OPINION IN HEMATOLOGY (2007)
Development of calpain-specific inactivators by screening of positional scanning epoxide libraries
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Contribution of calpains to photoreceptor cell death in N-methyl-N-nitrosourea-treated rats
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EXPERIMENTAL NEUROLOGY (2007)
The calpains: modular designs and functional diversity
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GENOME BIOLOGY (2007)
Calpain activity in retinal degeneration
Francois Paquet-Durand et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2007)
Synthesis of a 24-membered cyclic peptide-biphenyl hybrid
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EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2007)
A new cell-permeable calpain inhibitor
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JOURNAL OF PEPTIDE SCIENCE (2007)
Retinal penetration of calpain inhibitors in rats after oral administration
Yoshihisa Shirasaki et al.
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2006)
Inhibition of calpain-mediated cell death by a novel peptide inhibitor
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EXPERIMENTAL NEUROLOGY (2006)
The therapeutic potential of the calpain family: new aspects
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DRUG DISCOVERY TODAY (2006)
Synthesis, calpain inhibitory activity, and cytotoxicity of P2-substituted proline and thiaproline peptidyl aldehydes and peptidyl α-ketoamides
Rajani Korukonda et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Implication of calpain in neuronal apoptosis - A possible regulation of Alzheimer's disease
F. Raynaud et al.
FEBS JOURNAL (2006)
Calpain inhibitors and antioxidants act synergistically to prevent cell necrosis:: effects of the novel dual inhibitors (cysteine protease inhibitor and antioxidant) BN 82204 and its pro-drug BN 82270
Bernadette Pignol et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Exploration of orally available calpain inhibitors 2: Peptidyl hemiacetal derivatives
Yoshihisa Shirasaki et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Calpain inhibition by α-ketoamide and cyclic hemiacetal inhibitors revealed by X-ray crystallography
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BIOCHEMISTRY (2006)
Synthesis and evaluation of calpain inhibitors carrying muscle cell targeting groups
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LETTERS IN DRUG DESIGN & DISCOVERY (2006)
A novel series of urea-based peptidomimetic calpain inhibitors
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Novel dual inhibitors of calpain and lipid peroxidation with enhanced cellular activity
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Molecular mode of action of a covalently inhibiting peptidomimetic on the human calpain protease core
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BIOCHEMISTRY (2006)
Human immunodeficiency virus (HIV)-induced neurotoxicity: Roles for the NMDA receptor subtypes 2A and 2B and the calcium-activated protease calpain by a CSF-derived HIV-1 strain
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Calpain inhibition: A therapeutic strategy targeting multiple disease states
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Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression
MU Fareed et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2006)
Amelioration of retinal degeneration and proteolysis in acute ocular hypertensive rats by calpain inhibitor ((1s)-1-((((1s)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl) amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester
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NEUROSCIENCE (2006)
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D Cuerrier et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Novel cell-penetrating α-keto-amide calpain inhibitors as potential treatment for muscular dystrophy
C Lescop et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia
SX Jiang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Identification of a novel calpain inhibitor using phage display
RP Guttmann et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Exploration of orally available calpain inhibitors:: Peptidyl α-ketoamides containing an amphiphile at P3 site
Y Shirasaki et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Synthesis of a small library of diketopiperazines as potential inhibitors of calpain
YB Zeng et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Mechanisms of disease: Calpains and disease
M Zatz et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Synthesis and biological evaluation of chrohlone carboxamides as calpain inhibitors
KS Lee et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Calpain inhibition and insulin action in cultured human muscle cells
LJ Logie et al.
MOLECULAR GENETICS AND METABOLISM (2005)
Proteases universally recognize beta strands in their active sites
JDA Tyndall et al.
CHEMICAL REVIEWS (2005)
Ritonavir does not inhibit calpain in vitro
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
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PEPTIDES (2005)
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Structure, activation, and biology of calpain
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DIABETES (2004)
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Crystal structures of calpain-E64 and -leupeptin inhibitor complexes reveal mobile loops gating the active site
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JOURNAL OF MOLECULAR BIOLOGY (2004)
Studies on aromatic compounds:: inhibition of calpain I by biphenyl derivatives and peptide-biphenyl hybrids
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
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JOURNAL OF MEDICINAL CHEMISTRY (2004)
Reduction of myocardial infarction by calpain inhibitors A-705239 and A-705253 in isolated perfused rabbit hearts
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BIOLOGICAL CHEMISTRY (2004)
Solid-phase combinatorial synthesis of peptide-biphenyl hybrids as calpain inhibitors
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ORGANIC LETTERS (2004)
Peptidic aldehydes based on alpha- and beta-amino acids: Synthesis, inhibition of m-calpain, and anti-cataract properties
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AUSTRALIAN JOURNAL OF CHEMISTRY (2004)
Peptide-biphenyl hybrids as calpain inhibitors
A Montero et al.
CHEMISTRY & BIODIVERSITY (2004)
Poly-arginine-fused calpastatin peptide, a living cell membrane-permeable and specific inhibitor for calpain
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NEUROSCIENCE RESEARCH (2003)
Benzoylalanine-derived ketoamides carrying vinylbenzyl amino residues:: Discovery of potent water-soluble calpain inhibitors with oral bioavailability
W Lubisch et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Calpain is involved in the HIV replication from the latently infected OM10.1 cells
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Exploration of cornea permeable calpain inhibitors as anticataract agents
M Nakamura et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2003)
Peptidyl aldehyde inhibitors of calpain incorporating P2-proline mimetics
IO Donkor et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Structural determinants of the calpain inhibitory activity of calpastatin peptide B27-WT
R Betts et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin
S Gil-Parrado et al.
BIOLOGICAL CHEMISTRY (2003)
Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor
J Inoue et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Novel 6-hydroxy-3-morpholinones as cornea permeable calpain inhibitors
M Nakamura et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2003)
Calpain inhibitors, a treatment for Alzheimer's disease - Position paper
F Battaglia et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2003)
Exploration of peptidyl hydrazones as water-soluble calpain inhibitors
M Nakamura et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2002)
Discovery of phenyl alanine derived ketoamides carrying benzoyl residues as novel calpain inhibitors
W Lubisch et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2002)
Ritonavir inhibition of calcium-activated neutral proteases
WS Wan et al.
BIOCHEMICAL PHARMACOLOGY (2002)
A Ca2+ switch aligns the active site of calpain
T Moldoveanu et al.
CELL (2002)
The novel calpain inhibitor SJA6017 improves functional outcome after delayed administration in a mouse model of diffuse brain injury
NC Kupina et al.
JOURNAL OF NEUROTRAUMA (2001)
1,2-benzothiazine 1,1-dioxide P2-P3 peptide mimetic aldehyde calpain I inhibitors
GJ Wells et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
Synthesis of a reported calpain inhibitor isolated from Streptomyces griseus
IO Donkor et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2001)
Potent peptide α-ketohydroxamate inhibitors of recombinant human calpain I
KA Josef et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2001)
VE-cadherin-derived cell-penetrating peptide, pVEC, with carrier functions
A Elmquist et al.
EXPERIMENTAL CELL RESEARCH (2001)
Significance of hydrogen bonding at the S1′ subsite of calpain I
IO Donkor et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2001)
Calpain inhibitor, SJA6017, reduces the rate of formation of selenite cataract in rats
Y Tamada et al.
CURRENT EYE RESEARCH (2001)
A survey of calpain inhibitors
IO Donkor
CURRENT MEDICINAL CHEMISTRY (2000)
Synthesis and calpain inhibitory activity of α-ketoamides with 2,3-methanoleucine stereoisomers at the P2 position
IO Donkor et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2000)
Calpain inhibitors based on the quiescent affinity label concept:: High rates of calpain inactivation with leaving groups derived from N-hydroxy peptide coupling reagents
R Tripathy et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2000)
Synthesis and biological evaluation of novel piperidine carboxamide derived calpain inhibitors
W Lubisch et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2000)
Calpains and muscular dystrophies
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INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2000)
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