期刊
EXPERT OPINION ON THERAPEUTIC PATENTS
卷 18, 期 8, 页码 889-901出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/13543776.18.8.889
关键词
EGFR; HER; monoclonal antibody; targeted therapy; tyrosine kinase inhibitor
Background: The 'targeted therapy' has been defined as an innovative therapy designed to interfere with molecular targets playing a critical role in tumour growth or progression. The epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor mediating the effect of growth factors both in physiological and pathological conditions; aberrations in the EGFR may result in the development of a tumour phenotype. Objective: To summarise the current state of the development of anti-EGFR drugs. Methods: Patent literature and preclinical/clinical studies about EGFR inhibitors are analysed. Conclusion: Some monoclonal antibodies and small-molecule tyrosine kinase inhibitors have been approved in several countries for the treatment of various human cancer types; moreover, more than ten EGFR-targeting agents are actually in advanced clinical development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据