相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects
Richard A. Graham et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2012)
Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer
Hideya Onishi et al.
CANCER SCIENCE (2012)
Basal cell carcinoma - molecular biology and potential new therapies
Maria Kasper et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Hedgehog-GLI Pathway in Medulloblastoma
Tenley C. Archer et al.
JOURNAL OF CLINICAL ONCOLOGY (2012)
Inhibiting the Hedgehog Pathway in Patients with the Basal-Cell Nevus Syndrome
Jean Y. Tang et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma
Aleksandar Sekulic et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance
Gerrit J. P. Dijkgraaf et al.
CANCER RESEARCH (2011)
Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists
Ciara Metcalfe et al.
CANCER RESEARCH (2011)
A Single Dose Mass Balance Study of the Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Humans Using Accelerator Mass Spectrometry
Richard A. Graham et al.
DRUG METABOLISM AND DISPOSITION (2011)
Mommy - where do tumors come from?
Ervin H. Epstein
JOURNAL OF CLINICAL INVESTIGATION (2011)
Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations
Marina Grachtchouk et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Topical Treatment of Basal Cell Carcinomas in Nevoid Basal Cell Carcinoma Syndrome with a Smoothened Inhibitor
Hans Skvara et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)
A germline variant in the TP53 polyadenylation signal confers cancer susceptibility
Simon N. Stacey et al.
NATURE GENETICS (2011)
Emerging Treatments and Signaling Pathway Inhibitors
Jean Y. Tang et al.
SEMINARS IN CUTANEOUS MEDICINE AND SURGERY (2011)
Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
James Kim et al.
CANCER CELL (2010)
Role of High-Dose Chemotherapy for Recurrent Medulloblastoma and Other CNS Primitive Neuroectodermal Tumors
Amar Gajjar et al.
PEDIATRIC BLOOD & CANCER (2010)
Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma
Silvia Buonamici et al.
SCIENCE TRANSLATIONAL MEDICINE (2010)
GDC-0449-A potent inhibitor of the hedgehog pathway
Kirk D. Robarge et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Bazex-Dupre-Christol syndrome: An ectodermal dysplasia with skin appendage neoplasms
Marco Castori et al.
EUROPEAN JOURNAL OF MEDICAL GENETICS (2009)
Brief Report: Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449.
Charles M. Rudin et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma.
Daniel D. Von Hoff et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
Robert L. Yauch et al.
SCIENCE (2009)
Guidelines for the management of basal cell carcinoma
N. R. Telfer et al.
BRITISH JOURNAL OF DERMATOLOGY (2008)
Acquired resistance to tyrosine kinase inhibitors during cancer therapy
Jeffrey A. Engelman et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2008)
Short guidelines - Basal cell carcinoma of the skin
Axel Hauschild et al.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (2008)
Chronic diseases requiring hospitalization and risk of non-melanoma skin cancers - A population based study from Denmark
Annette O. Jensen et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2008)
Pediatric basal cell carcinoma: case reports and literature review
Philip A. Efron et al.
JOURNAL OF PEDIATRIC SURGERY (2008)
A clinical study comparing methyl aminolevulinate photodynamic therapy and surgery in small superficial basal cell carcinoma (8-20 mm), with a 12-month follow-up
R. M. Szeimies et al.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2008)
A paracrine requirement for hedgehog signalling in cancer
Robert L. Yauch et al.
NATURE (2008)
Nevoid basal cell carcinoma syndrome (Gorlin syndrome)
Lorenzo Lo Muzio
ORPHANET JOURNAL OF RARE DISEASES (2008)
Multiple basal cell carcinomas in xeroderma pigmentosum treated with imiquimod 5% cream
Amit Kumar Malhotra et al.
PEDIATRIC DERMATOLOGY (2008)
Early events in UV carcinogenesis - DNA damage, target cells and mutant p53 foci
Frank R. de Gruijl et al.
PHOTOCHEMISTRY AND PHOTOBIOLOGY (2008)
Basal cell carcinomas: attack of the hedgehog
Ervin H. Epstein
NATURE REVIEWS CANCER (2008)
Basal cell carcinoma in childhood: Case report and literature review
John R. Griffin et al.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2007)
Basal cell carcinoma in five albino Africans from the south-eastern equatorial rain forest of Nigeria
Maurice E. Asuquo et al.
INTERNATIONAL JOURNAL OF DERMATOLOGY (2007)
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
Matthias Lauth et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Topical imiquimod - A review of its use in the management of anogenital warts, actinic keratoses, basal cell carcinoma and other skin lesions
Antona J. Wagstaff et al.
DRUGS (2007)
Non-Hodgkin lymphoma and skin cancer: A dangerous combination
Clark C. Otley
AUSTRALASIAN JOURNAL OF DERMATOLOGY (2006)
Radiation-induced cutaneous carcinoma of the head and neck: is there an early role for p53 mutations?
A. Franchi et al.
CLINICAL AND EXPERIMENTAL DERMATOLOGY (2006)
Melanocortin 1 receptor variants and skin cancer risk
Jiali Han et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
Long-term health risk to the skin of ultraviolet radiation
RM MacKie
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2006)
MC1R and PTCH gene polymorphism in French patients with basal cell carcinomas
Muriel Liboutet et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2006)
Genornics identifies medulloblastoma subgroups that are enriched for specific genetic alterations
MC Thompson et al.
JOURNAL OF CLINICAL ONCOLOGY (2006)
Patched1 functions as a gatekeeper by promoting cell cycle progression
C Adolphe et al.
CANCER RESEARCH (2006)
Arsenic carcinogenesis in the skin
Hsin-Su Yu et al.
JOURNAL OF BIOMEDICAL SCIENCE (2006)
Clinical testing for the nevoid basal cell carcinoma syndrome in a DNA diagnostic laboratory
RD Klein et al.
GENETICS IN MEDICINE (2005)
Incidence of basal cell and squamous cell carcinomas in a population younger than 40 years
LJ Christenson et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2005)
Nonmelanoma skin cancer in relation to ionizing radiation exposure among US radiologic technologists
S Yoshinaga et al.
INTERNATIONAL JOURNAL OF CANCER (2005)
Mutations induced by ultraviolet light
GP Pfeifer et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2005)
Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle
ME Hutchin et al.
GENES & DEVELOPMENT (2005)
Low dose exposure to sodium arsenite synergistically interacts with UV radiation to induce mutations and alter DNA repair in human cells
H Danaee et al.
MUTAGENESIS (2004)
Identification and characterization of pDC-like cells in normal mouse skin and melanomas treated with imiquimod
F Palamara et al.
JOURNAL OF IMMUNOLOGY (2004)
Sonic hedgehog exerts distinct, stage-specific effects on tongue and taste papilla development
HX Liu et al.
DEVELOPMENTAL BIOLOGY (2004)
The genetics of sun sensitivity in humans
JL Rees
AMERICAN JOURNAL OF HUMAN GENETICS (2004)
Mechanism of arsenic carcinogenesis: an integrated approach
Toby G. Rossman
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2003)
Hedgehog signalling in cancer formation and maintenance
MP di Magliano et al.
NATURE REVIEWS CANCER (2003)
Mechanisms underlying imiquimod-induced regression of basal cell carcinoma in vivo
M Urosevic et al.
ARCHIVES OF DERMATOLOGY (2003)
Disruption of Sonic hedgehog signaling alters growth and patterning of lingual taste papillae
JMH Hall et al.
DEVELOPMENTAL BIOLOGY (2003)
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
JK Chen et al.
GENES & DEVELOPMENT (2002)
Mutations of the p53 and PTCH gene in basal cell carcinomas:: UV mutation signature and strand bias
MY Kim et al.
JOURNAL OF DERMATOLOGICAL SCIENCE (2002)
Molecular mechanisms regulating hair follicle development
SE Millar
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2002)
The epidemiology of UV induced skin cancer
BK Armstrong et al.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2001)
Skin cancer risk in relation to toenail arsenic concentrations in a US population-based case-control study
MR Karagas et al.
AMERICAN JOURNAL OF EPIDEMIOLOGY (2001)
Risk of developing a subsequent nonmelanoma skin cancer in patients with a history of nonmelanoma skin cancer - A critical review of the literature and meta-analysis
I Marcil et al.
ARCHIVES OF DERMATOLOGY (2000)
Cosmetic results of cryosurgery versus surgical excision for primary uncomplicated basal cell carcinomas of the head and neck
MRTM Thissen et al.
DERMATOLOGIC SURGERY (2000)