期刊
EXPERT OPINION ON PHARMACOTHERAPY
卷 13, 期 3, 页码 345-355出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14656566.2012.652086
关键词
adherence; antihypertensives; compliance; hypertension control; persistence; single-pill combination therapy
资金
- Boehringer Ingelheim International GmbH
Introduction: The majority of patients with hypertension require combination therapy to achieve their blood pressure (BP) goal. Studies have consistently shown that polypharmacy and complex treatment regimens have a detrimental effect on treatment compliance, adherence and persistence (herein referred to as treatment adherence). Areas covered: This paper reviews the available clinical evidence, as well as guidelines, which propose combinations of an angiotensin II receptor blocker (ARB) or an angiotensin-converting enzyme (ACE) inhibitor plus a calcium channel blocker (CCB) or diuretic. Expert opinion: ARBs are associated with better tolerability compared with ACE inhibitors, and data suggest that ARB/CCB combinations may be better tolerated than CCB monotherapy. The use of true once-daily single-pill combination therapy with effective and well-tolerated agents will reduce pill burden, simplify treatment regimens and improve treatment adherence, which will, in turn, help patients to reach and maintain their BP target and achieve the short-and long-term treatment goal of cardiovascular risk reduction.
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