期刊
EXPERT OPINION ON PHARMACOTHERAPY
卷 10, 期 11, 页码 1793-1804出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14656560903018911
关键词
exercise; information; NSAIDs; nutraceuticals; osteoarthritis; paracetamol; weight loss
资金
- Danish National Board of Health
Osteoarthritis (OA) is a major cause of disability, which will increase further with longer lifetime and higher average weight of the population. Objective: To review a hierarchy of interventions for OA in clinical practice, and compare it with the Strength of Recommendation (SOR) proposed by the Osteoarthritis Research Society International (OARSI). Methods: Search for relevant randomized controlled trials in databases, as well as published systematic reviews and meta-analyses. Resuits/conclusions: Preventive measures are few and uncertain; however, basic therapy includes reduction in weight in the obese and exercises to keep in shape; this is in accordance with the OARSI guidelines (OARSI; 100% consensus) emphasizing the need for obese individuals with knee OA to lose weight (OARSI, SOR = 96%). There are indications of an effect of some nutraceuticals, though further studies are needed for validation (OARSI, SOR = 63%). Pharmacological treatment has paracetamol as primary prescription, which is a safe, albeit weak analgesic. Supplementary medications are prescribed according to level of pain and possible inflammation.
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