期刊
EXPERT OPINION ON PHARMACOTHERAPY
卷 9, 期 3, 页码 459-465出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14656566.9.3.459
关键词
childhood onset schizophrenia; clozapine; management; side effects; treatment refractory
Background: Although the role of clozapine is well established for treatment-resistant schizophrenia, it is rarely used in pediatric populations, mainly due to its potentially serious adverse effects. Objective: To summarize practical aspects of use of clozapine in treating children with schizophrenia and management of associated adverse effects. Methods: Available studies in the literature using clozapine in the pediatric population are summarized and the NIMH experience in treating refractory childhood-onset schizophrenia cases with clozapine is discussed. Conclusion: Despite a higher incidence of adverse effects in children, clozapine appears to be a uniquely beneficial second-line agent for treating children with refractory schizophrenia.
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