相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Stress Hormone Regulation: Biological Role and Translation into Therapy
Florian Holsboer et al.
ANNUAL REVIEW OF PSYCHOLOGY (2010)
Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties
John E. Tellew et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
MULTICENTER, RANDOMIZED, DOUBLE-BLIND, ACTIVE COMPARATOR AND PLACEBO-CONTROLLED TRIAL OF A CORTICOTROPIN-RELEASING FACTOR RECEPTOR-1 ANTAGONIST IN GENERALIZED ANXIETY DISORDER
Vladimir Coric et al.
DEPRESSION AND ANXIETY (2010)
Progress in corticotropin-releasing factor-1 antagonist development
Eric P. Zorrilla et al.
DRUG DISCOVERY TODAY (2010)
Individual Stress Vulnerability Is Predicted by Short-Term Memory and AMPA Receptor Subunit Ratio in the Hippocampus
Mathias V. Schmidt et al.
JOURNAL OF NEUROSCIENCE (2010)
Conditional corticotropin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep
M. Kimura et al.
MOLECULAR PSYCHIATRY (2010)
Ten years of Nature Reviews Neuroscience: insights from the highly cited
Liqun Luo et al.
NATURE REVIEWS NEUROSCIENCE (2010)
Polymorphisms in GRIK4, HTR2A, and FKBP5 Show Interactive Effects in Predicting Remission to Antidepressant Treatment
Sonja Horstmann et al.
NEUROPSYCHOPHARMACOLOGY (2010)
Therapeutic utility of non-peptidic CRF1 receptor antagonists in anxiety, depression, and stress-related disorders: Evidence from animal models
John H. Kehne et al.
PHARMACOLOGY & THERAPEUTICS (2010)
Dose-dependent effects of the CRF1 receptor antagonist R317573 on regional brain activity in healthy male subjects
Mark E. Schmidt et al.
PSYCHOPHARMACOLOGY (2010)
Do corticotropin releasing factor-1 receptors influence colonic transit and bowel function in women with irritable bowel syndrome?
Seth Sweetser et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2009)
8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: Selective and Centrally Active Corticotropin-Releasing Factor Receptor-1 (CRF1) Antagonists
Paul J. Gilligan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Drugability of Extracellular Targets: Discovery of Small Molecule Drugs Targeting Allosteric, Functional, and Subunit-Selective Sites on GPCRs and Ion Channels
Dimitri E. Grigoriadis et al.
NEUROPSYCHOPHARMACOLOGY (2009)
A 6-week randomized, placebo-controlled trial of CP-316,311 (a selective CRH1 antagonist) in the treatment of major depression
Brendon Binneman et al.
AMERICAN JOURNAL OF PSYCHIATRY (2008)
The FKBP5-gene in depression and treatment response -: An association study in the sequenced treatment alternatives to relieve depression (STAR*D) cohort
Magnus Lekman et al.
BIOLOGICAL PSYCHIATRY (2008)
Small molecule antagonists of the corticotropin releasing factor (CRF) receptor: Recent medicinal chemistry developments
John E. Tellew et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2008)
Synthesis and Pharmacological Characterization of Novel Druglike Corticotropin-Releasing Factor 1 Antagonists
Romano Di Fabio et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Synthesis and SAR of 2-aryloxy-4-alkoxy-pyridines as potent orally active corticotropin-releasing factor 1 receptor antagonists
Yuhpyng L. Chen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Allosteric ligands for the corticotropin releasing factor type 1 receptor modulate conformational states involved in receptor activation
Sam R. J. Hoare et al.
MOLECULAR PHARMACOLOGY (2008)
Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior
A. Lu et al.
MOLECULAR PSYCHIATRY (2008)
Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression
Manfred Uhr et al.
NEURON (2008)
Genetic variants in FKBP5 affecting response to antidepressant drug treatment
Julia Kirchheiner et al.
PHARMACOGENOMICS (2008)
The link between childhood trauma and depression: Insights from HPA axis studies in humans
Christine Heim et al.
PSYCHONEUROENDOCRINOLOGY (2008)
New G-protein-coupled receptor crystal structures: insights and limitations
Brian Kobilka et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2008)
High-affinity CRF1 receptor antagonist NBI-34041:: Preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response
Marcus Ising et al.
NEUROPSYCHOPHARMACOLOGY (2007)
Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression -: A potential biomarker?
Marcus Ising et al.
BIOLOGICAL PSYCHIATRY (2007)
PET Imaging of CRF1 with [11C]R121920 and [11C]DMP696:: is the target of sufficient density?
Gregory M. Sullivan et al.
NUCLEAR MEDICINE AND BIOLOGY (2007)
3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine:: A novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism
Donald R. Gehlert et al.
JOURNAL OF NEUROSCIENCE (2007)
Association study of corticotropin-releasing hormone receptor1 gene polymorphisms and antidepressant response in major depressive disorders
Zhongchun Liu et al.
NEUROSCIENCE LETTERS (2007)
Corticotropin releasing hormone - A GPCR drug target
C. F. Hemley et al.
CURRENT DRUG TARGETS (2007)
Single amino acid residue determinants of non-peptide antagonist binding to the corticotropin-releasing factor1 (CRF1) receptor
Sam R. J. Hoare et al.
BIOCHEMICAL PHARMACOLOGY (2006)
Synthesis and in vivo evaluation of [11C]SN003 as a PET ligand for CRF1 receptors
J. S. Dileep Kumar et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Polymorphisms of the glucocorticoid receptor gene and major depression
EFC van Rossum et al.
BIOLOGICAL PSYCHIATRY (2006)
Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: Implications for clinical practice
MH Trivedi et al.
AMERICAN JOURNAL OF PSYCHIATRY (2006)
Development of CRF1 receptor antagonists as antidepressants and anxiolytics - Progress to date
Glenn R. Valdez
CNS DRUGS (2006)
Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists
RS Gross et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
The corticotropin-releasing factor receptor: a novel target for the treatment of depression and anxiety-related disorders
DE Grigoriadis
EXPERT OPINION ON THERAPEUTIC TARGETS (2005)
The combined dexamethasone/CRH test as a potential surrogate marker in depression
M Ising et al.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2005)
Stress, genes and the mechanism of programming the brain for later life
ER de Kloet et al.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2005)
Mechanisms of peptide and nonpeptide ligand binding to class B G-protein coupled receptors
SRJ Hoare
DRUG DISCOVERY TODAY (2005)
Treatment with a CRH-1-receptor antagonist (R121919) does not affect weight or plasma leptin concentration in patients with major depression
HE Künzel et al.
JOURNAL OF PSYCHIATRIC RESEARCH (2005)
Stress and central Urocortin increase anxiety-like behavior in the social interaction test via the CRF1 receptor
DR Gehlert et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2005)
Prevalence, co-morbidity and correlates of mental disorders in the general population:: results from the German Health Interview and Examination Survey (GHS)
F Jacobi et al.
PSYCHOLOGICAL MEDICINE (2004)
Ligand affinity for amino-terminal and juxtamembrane domains of the corticotropin releasing factor type I receptor: Regulation by G-protein and nonpeptide antagonists
SRJ Hoare et al.
BIOCHEMISTRY (2004)
Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] administered acutely or chronically at doses occupying central CRF1 receptors in rats
S Lelas et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Treatment with the C RH1-receptor-antagonist R121919 improves sleep-EEG in patients with depression
K Held et al.
JOURNAL OF PSYCHIATRIC RESEARCH (2004)
Dysregulation in the suicide brain:: mRNA expression of corticotropin-releasing hormone receptors and GABAA receptorsubunits in frontal cortical brain region
Z Merali et al.
JOURNAL OF NEUROSCIENCE (2004)
Anxiolytic- and antidepressant-like profile of a new CRF1 receptor antagonist, R278995/CRA0450
S Chaki et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylamino-pyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure-activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists
C Chen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment
EB Binder et al.
NATURE GENETICS (2004)
The therapeutic potential of CRF1 antagonists for anxiety
EP Zorrilla et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2004)
Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans
J Licinio et al.
MOLECULAR PSYCHIATRY (2004)
Synthesis of [O-methyl-11C]-4-(1,3-dimethoxy-2-propylamino)-2,7-dimethyl-8-(2,4-dichlorophenyl)[1,5-a]pyrazolo-1,3,5-triazine ([11C]DMP696):: a potential PET ligand for CRF1 receptors
JSD Kumar et al.
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS (2004)
Corticotropin-releasing factor in brain: A role in activation, arousal, and affect regulation
SC Heinrichs et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Conformational states of the corticotropin releasing factor 1 (CRF1) receptor:: detection, and pharmacological evaluation by peptide ligands
SRJ Hoare et al.
PEPTIDES (2003)
Synthesis of [N-methyl-11C]-3-[(6-dimethylamino)pyridin-3-yl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidine-7-amine:: A potential PET ligand for in vivo imaging of CRF1 receptors
JSD Kumar et al.
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS (2003)
Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress
MB Müller et al.
NATURE NEUROSCIENCE (2003)
When not enough is too much: The role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders
CL Raison et al.
AMERICAN JOURNAL OF PSYCHIATRY (2003)
Receptor occupancy of nonpeptide corticotropin-releasing factor 1 antagonist DMP696: Correlation with drug exposure and anxiolytic efficacy
YW Li et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
Epidemiology of women and depression
RC Kessler
JOURNAL OF AFFECTIVE DISORDERS (2003)
The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress
DA Gutman et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
Glucocorticoid-induced increase in lymphocytic FKBP51 messenger ribonucleic acid expression: A potential marker for glucocorticoid sensitivity, potency, and bioavailability
H Vermeer et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)
Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects
HE Kunzel et al.
JOURNAL OF PSYCHIATRIC RESEARCH (2003)
Knockouts model the 100 best-selling drugs - Will they model the next 100?
BP Zambrowicz et al.
NATURE REVIEWS DRUG DISCOVERY (2003)
Small molecule corticotropin-releasing factor antagonists
M Lanier et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2002)
Brain penetrance, receptor occupancy and antistress in vivo efficacy of a small molecule corticotropin releasing factor type I receptor selective antagonist
SC Heinrichs et al.
NEUROPSYCHOPHARMACOLOGY (2002)
4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine hydrochloride (SSR125543A):: A potent and selective corticotrophin-releasing factor1 receptor antagonist.: I.: Biochemical and pharmacological characterization
D Gully et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression
JMHM Reul et al.
CURRENT OPINION IN PHARMACOLOGY (2002)
CRHR1 receptor binding and lipophilicity of pyrrolopyrimidines, potential nonpeptide corticotropin-releasing hormone type 1 receptor antagonists
LW Hsin et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2002)
Non-Peptidic CRF1 Receptor Antagonists for the Treatment of Anxiety, Depression and Stress Disorders
J. Kehne et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2002)
Similar effectiveness of paroxetine, fluoxetine, and sertraline in primary care - A randomized trial
K Kroenke et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2001)
Overexpression of the FK506-binding immunophilin FKBP51 is the common cause of glucocorticoid resistance in three new world primates
JG Scammell et al.
GENERAL AND COMPARATIVE ENDOCRINOLOGY (2001)
Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor
K Lewis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor
SY Hsu et al.
NATURE MEDICINE (2001)
Animal models of CRH excess and CRH receptor deficiency display altered adaptations to stress
SC Coste et al.
PEPTIDES (2001)
Glucocorticoid receptors in major depression: Relevance to pathophysiology and treatment
CM Pariante et al.
BIOLOGICAL PSYCHIATRY (2001)
Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors
TM Reyes et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Current trends in the development of new antidepressants
P Pacher et al.
CURRENT MEDICINAL CHEMISTRY (2001)
Synthesis and characterization of fluorinated and iodinated pyrrolopyrimidines as PET/SPECT ligands for the CRF1 receptor
L Martarello et al.
NUCLEAR MEDICINE AND BIOLOGY (2001)
Stress, hypercortisolism and corticosteroid receptors in depression: implicatons for therapy
F Holsboer
JOURNAL OF AFFECTIVE DISORDERS (2001)
The anxiolytic effect of the CRH1 receptor antagonist R121919 depends on innate emotionality in rats
ME Keck et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2001)
The neurobiology of urocortin
KH Skelton et al.
REGULATORY PEPTIDES (2000)
Synthesis and biological activity of fluoro-substituted pyrrolo[2,3-d]pyrimidines:: The development of potential positron emission tomography imaging agents for the corticotropin-releasing hormone type 1 receptor
LW Hsin et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2000)
Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression:: the first 20 patients treated
AW Zobel et al.
JOURNAL OF PSYCHIATRIC RESEARCH (2000)
分享论文
