期刊
EXPERT OPINION ON INVESTIGATIONAL DRUGS
卷 19, 期 2, 页码 215-234出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/13543780903505092
关键词
antibacterial; drug discovery; drug resistance
资金
- NIH [5U01AI075520, 5R01DK073823]
Importance of the field. Antibacterial drug discovery and development has slowed considerably in recent years, with novel classes discovered decades ago and regulatory approvals tougher to get. Traditional approaches and the newer genomic mining approaches have not yielded novel classes of antibacterial compounds. Instead, improved analogues of existing classes of antibacterial drugs have been developed by improving potency, minimizing resistance and alleviating toxicity. Areas covered in this review. This article is a comprehensive review of newer classes of antibacterial drugs introduced or approved after year 2000. What the reader will gain: it describes their mechanisms of action/resistance, improved analogues, spectrum of activity and clinical trials. it also discusses new compounds in development with novel mechanisms of action, as well as novel unexploited bacterial targets and strategies that may pave the way for combating drug resistance and emerging pathogens in the twenty-first century. Take home message: The outlook of antibacterial drug discovery, though challenging, may not be insurmountable in the years ahead, with legislation on incentives and funding introduced for developing an antimicrobial discovery program and efforts to conserve antibacterial drug use.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据