期刊
EXPERT OPINION ON INVESTIGATIONAL DRUGS
卷 18, 期 12, 页码 1919-1927出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/13543780903376163
关键词
foam; microfoam; polidocanol; sclerosant; sclerotherapy; varicose veins
资金
- NHLBI NIH HHS [R01 HL067986-05A2, R01 HL67986, R01 HL067986] Funding Source: Medline
Background: Polidocanol is a liquid surfactant having endothelial cell lytic properties. in the form of a controlled, dispensed microfoam it is administered endovenously as a sclerosing agent in the treatment of varicose veins. Objective: This review summarizes efficacy of polidocanol endovenous microfoam sclerotherapy using a proprietary dispensing system to control foam characteristics and gas content for treating varicose veins. Methods: We reviewed in vitro, Phase I, Phase II and limited Phase III data for polidocanol microfoam with a focus on controlled foam formulation in therapy. Results/conclusions: Clinical trials of controlled dispensing of polidocanol microfoam provide evidence of effective treatment of chronic venous insufficiency with low toxicity, minimal risk and few complications.
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