期刊
EXPERT OPINION ON EMERGING DRUGS
卷 17, 期 1, 页码 11-15出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728214.2012.664132
关键词
carbonic anhydrase; mitochondrial enzyme; obesity; topiramate
Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes in mammals, being involved in numerous biosynthetic processes, including gluconeogenesis, lipogenesis and ureagenesis. It has recently emerged that CA inhibitors (CAIs) targeting the mitochondrial isoforms CA VA and VB have potential as novel antiobesity drugs. This Editorial discusses the biochemical and biological rationale for the use of CAIs in the management of obesity.
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