期刊
EXPERT OPINION ON DRUG SAFETY
卷 12, 期 5, 页码 697-707出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14740338.2013.806480
关键词
antiretroviral drugs; hepatitis; HIV; rash; toxicity
资金
- European Network of AIS Trials (NEAT, FP6 project) [LSHP-CT-2006-037570]
- Fondo de Investigacion Sanitaria - Red de Investigacion en SIDA (RIS) [RD12/0017/0031]
- Fundacion Investigacion y Educacion en SIDA
Introduction: The number of HIV patients receiving antiretroviral therapy is increasing worldwide, as new infections continue to occur and access to drugs is scaling up in most developing regions. Due to the efficacious nature of combination antiretroviral therapy in most drug-adherent patients, the concerns on the safety profile of these lifelong medicines have attracted great attention. Areas covered: Side effects of antiretroviral agents can be clinically symptomatic or manifest only as laboratory abnormalities. Drug-related toxicities can be grouped by antiretroviral drug class or damage of distinct body organs/systems. By mechanism, antiretroviral-associated adverse events generally result from hypersensitivity reactions, direct cytopathic effect, or idiosyncratic phenomena. Expert opinion: A good knowledge of the toxicity profile of antiretroviral agents is warranted for HIV care providers in order to prevent and avoid unwanted complications.
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