期刊
EXPERT OPINION ON DRUG SAFETY
卷 11, 期 4, 页码 565-579出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14740338.2012.691963
关键词
peroxisome proliferator-activated receptor (PPAR) gamma agonists; pioglitazone; rosiglitazone; thiazolidinediones; type 2 diabetes
资金
- GlaxoSmithKline
- Takeda
- Roche Pharmaceuticals
Introduction: Thiazolidinediones (TZDs) initially showed great promise as unique receptor-mediated oral therapy for type 2 diabetes, but a host of serious side effects, primarily cardiovascular, have limited their utility. It is crucial at this point to perform a risk-benefit analysis to determine what role TZDs should play in our current treatment of type 2 diabetes and where the future of this class of drugs is headed. Areas covered: This review provides a comprehensive overview of the literature from 2000 onward reporting the known side effects of rosiglitazone and pioglitazone, with commentary on the quality of the data available, putative mechanism of each side effect and clinical significance. Finally, a perspective on the future of the TZDs as a class is provided. Expert opinion: The current TZDs are first-generation, non-specific activators of peroxisome proliferator-activated receptor (PPAR) gamma, resulting in a wide array of deleterious side effects that currently limit their use. However, the development of highly targeted selective PPAR gamma modulators (SPPAR gamma Ms) and dual PPAR gamma/alpha agonists is on the horizon.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据