期刊
EXPERT OPINION ON DRUG SAFETY
卷 9, 期 1, 页码 125-137出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14740330903485637
关键词
adverse effects; CYP2C19 protein; drug monitoring; drug toxicity; voriconazole
资金
- CAPES
- CNPq
- FAPERGS
- Myconostica
- Pfizer
- Merck
- Sigma-Tau
Importance of the field: Voriconazole has been widely used for the treatment of invasive fungal diseases, particularly invasive aspergillosis. Drug drug interactions are, however, the main drawback associated with voriconazole use, since this drug suffers from extensive hepatic metabolism. Areas covered in this review: This article reviews the current literature on voriconazole therapeutic drug monitoring, with a special focus on drug safety. What the reader will gain: An update on voriconazole metabolism, drug interactions, toxicity and the relation of these with voriconazole drug concentrations. Take home message: Therapy with voriconazole may be better guided by measuring voriconazole concentrations in the plasma.
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