期刊
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
卷 7, 期 3, 页码 325-339出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/17425255.2011.553188
关键词
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资金
- CIHR Vanier Canada
Areas covered: This review covers current research examining genetic polymorphisms in transporters expressed in the syncytiotrophoblast and evidence supporting the involvement of these transporters in the transport of oral antidiabetic agents. The aim is to provide insight into how the transfer of antidiabetic drugs across the placental trophoblast may be altered by polymorphisms in drug transporters. Expert opinion: There is a paucity of studies examining the influence of polymorphisms on transporter activity in the placenta and how the transfer of oral antidiabetics may be altered. Further research employing in vivo models is required to allow for the prediction of the potential consequences of polymorphisms on placental transporter expression and function.
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