期刊
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
卷 5, 期 12, 页码 1483-1499出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/17425250903304049
关键词
fetus; placenta; pregnancy; transporter protein; xenobiotic metabolism
资金
- EU [FOOD-CT-2005 01632, LSHB-CT-2004-503257]
Transporter proteins and xenobiotic metabolizing enzymes have a crucial role in the fate of xenobiotics in human body. The expression in human placenta and fetal tissues of the proteins most commonly participating in pharmaco/toxicokinetics is reviewed. In case human data are not available, relevant animal data are included. Among transporter proteins ABC transporters, monoamine transporters and organic anion transporters are pharmacologically and toxicologically of main interest. From xenobiotic enzymes, both CYP enzymes and transferases are expressed in fetal liver already during pregnancy. in the placenta, the variety of enzymes is much more restricted. During development dynamic changes occur in both xenobiotic metabolizing enzymes and drug transporters. Although the knowledge has increased substantially over the past years it is apparent from the literature that there are uncharacterized areas, especially regarding developmental expression patterns and regulation of transporters in fetal tissues and placenta. Knowledge about tissue-specific distribution and functional significance will aid our understanding of the differences in drug response and risks for adverse events during fetal development.
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