相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Stereospecific high-performance liquid chromatography of taxifolin, applications in pharmacokinetics, and determination in tu fu ling (Rhizoma smilacis glabrae) and apple (Malus x domestica)
Karina R. Vega-Villa et al.
BIOMEDICAL CHROMATOGRAPHY (2009)
Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia
Mitch A. Phelps et al.
BLOOD (2009)
Absorption, metabolism and excretion of flavanones from single portions of orange fruit and juice and effects of anthropometric variables and contraceptive pill use on flavanone excretion
Gary M. Brett et al.
BRITISH JOURNAL OF NUTRITION (2009)
Flavonoids, Vascular Function and Cardiovascular Protection
Davide Grassi et al.
CURRENT PHARMACEUTICAL DESIGN (2009)
Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction
Shuji Ohno et al.
DRUG METABOLISM AND DISPOSITION (2009)
UDP-Glucuronosyltransferases (UGTs) 2B7 and UGT2B17 Display Converse Specificity in Testosterone and Epitestosterone Glucuronidation, whereas UGT2A1 Conjugates Both Androgens Similarly
Taina Sten et al.
DRUG METABOLISM AND DISPOSITION (2009)
Intestinal first-pass glucuronidation activities of selected dihydroxyflavones
Yin Cheong Wong et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2009)
Quercetin Glucuronide Inhibits Cell Migration and Proliferation by Platelet-Derived Growth Factor in Vascular Smooth Muscle Cells
Keisuke Ishizawa et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2009)
Substrate specificity of plant UDP-dependent glycosyltransferases predicted from crystal structures and homology modeling
Sarah A. Osmani et al.
PHYTOCHEMISTRY (2009)
A Phase II Study of Flavopiridol (Alvocidib) in Combination with Docetaxel in Refractory, Metastatic Pancreatic Cancer
Richard D. Carvajal et al.
PANCREATOLOGY (2009)
Absorption, conjugation and efflux of the flavonoids, kaempferol and galangin, using the intestinal CaCo-2/TC7 cell model
Robert Barrington et al.
JOURNAL OF FUNCTIONAL FOODS (2009)
Intra-herb pharmacokinetics interaction between quercetin and isorhamentin
Ke Lan et al.
ACTA PHARMACOLOGICA SINICA (2008)
Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase
Yvonne Steffen et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2008)
A comparative study of the effects of quercetin and its glucuronide and sulfate metabolites on human neutrophil function in vitro
Sunita Suri et al.
BIOCHEMICAL PHARMACOLOGY (2008)
Glucuronidation of flavonoids by recombinant UGT1A3 and UGT1A9
Yakun Chen et al.
BIOCHEMICAL PHARMACOLOGY (2008)
Pharmacokinetics of selected chiral flavonoids:: Hesperetin, naringenin and eriodictyol in rats and their content in fruit juices
Jaime A. Yanez et al.
BIOPHARMACEUTICS & DRUG DISPOSITION (2008)
Phase I study of flavopiridol in combination with paclitaxel and carboplatin in patients with non-small-cell lung cancer
Saby George et al.
CLINICAL LUNG CANCER (2008)
Recent advances in the in silico modelling of UDP glucuronosyltransferase substrates
Michael J. Sorich et al.
CURRENT DRUG METABOLISM (2008)
Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines
Akiko Nakamura et al.
DRUG METABOLISM AND DISPOSITION (2008)
Plasma profiling of intact isoflavone metabolites by high-performance liquid chromatography and mass spectrometric identification of flavone glycosides daidzin and genistin in human plasma after administration of kinako
Kaori Hosoda et al.
DRUG METABOLISM AND DISPOSITION (2008)
The Configuration of the 17-Hydroxy Group Variably Influences the Glucuronidation of β-Estradiol and Epiestradiol by Human UDP-Glucuronosyltransferases
Katriina Itaaho et al.
DRUG METABOLISM AND DISPOSITION (2008)
Comparison of enzymically glucuronidated flavonoids with flavonoid aglycones in an in vitro cellular model of oxidative stress protection
David E. Stevenson et al.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2008)
Bioavailability and Metabolism of Orange Juice Flavanones in Humans: Impact of a Full-Fat Yogurt
William Mullen et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2008)
Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries - Implication in the anti-atherosclerotic mechanism of dietary flavonoids
Yoshichika Kawai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
A quantitative structure-activity relationship model for radical scavenging activity of flavonoids
A. Om et al.
JOURNAL OF MEDICINAL FOOD (2008)
Glucuronidation of the soyabean isoflavones genistein and daidzein by human liver is related to levels of UGT1A1 and UGT1A9 activity and alters isoflavone response in the MCF-7 human breast cancer cell line
Louise E. Pritchett et al.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2008)
Regioselectivity of human UDP-glucuronosyl-transferase 1A1 in the synthesis of flavonoid glucuronides determined by metal complexation and tandem mass spectrometry
Barry D. Davis et al.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2008)
Genistein- and daidzein 7-O-β-D-glucuronic acid retain the ability to inhibit copper-mediated lipid oxidation of low density lipoprotein
Tiny Kgomotso et al.
MOLECULAR NUTRITION & FOOD RESEARCH (2008)
Novel polymorphic human UDP-glucuronosyltransferase 2A3: Cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction
Michael H. Court et al.
MOLECULAR PHARMACOLOGY (2008)
Cancer phytotherapeutics: Role for flavonoids at the cellular level
Anup Kale et al.
PHYTOTHERAPY RESEARCH (2008)
Effect of dietary flavonoids on pathways involved in drug metabolism
Rainer Cermak
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2008)
Onions: A source of unique dietary flavonoids
Rune Slimestad et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2007)
Lack of association between common Polymorphisms in UGT1A9 and gene expression and activity
Jacqueline Ramirez et al.
DRUG METABOLISM AND DISPOSITION (2007)
Intestinal and hepatic glucuronidation of flavonoids
Li Zhang et al.
MOLECULAR PHARMACEUTICS (2007)
Synthesis of daidzein 7-O-β-D-glucuronide-4′-O-sulfate
Otto Soidinsalo et al.
STEROIDS (2007)
Disposition of flavonoids via enteric recycling: Determination of the UDP-Glucuronosyltransferase Isoforms responsible for the metabolism of flavonoids in intact caco-2 TC7 cells using siRNA
Xing Liu et al.
MOLECULAR PHARMACEUTICS (2007)
Biotransformation of green tea polyphenols and the biological activities of those metabolites
Joshua D. Lambert et al.
MOLECULAR PHARMACEUTICS (2007)
Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10
Sanna Kaivosaari et al.
MOLECULAR PHARMACOLOGY (2007)
The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential
Jelmer J. van Zanden et al.
BIOCHEMICAL PHARMACOLOGY (2007)
Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention
Sonia Ramos
JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2007)
Natural polyphenol disposition via coupled metabolic pathways
Zhongqiu Liu et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2007)
The anti-cancer charm of flavonoids: A cup-of-tea will do!
Amr Amin et al.
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY (2007)
SAR and QSAR of the antioxidant activity of flavonoids
Dragan Amic et al.
CURRENT MEDICINAL CHEMISTRY (2007)
Methods of analysis and separation of chiral flavonoids
Jaime A. Yanez et al.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2007)
In vitro metabolism of eupatilin by multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes
H. S. Lee et al.
XENOBIOTICA (2007)
Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas
Mendel Friedman
MOLECULAR NUTRITION & FOOD RESEARCH (2007)
Involvement of UDP-glucuronosyltransferases in the extensive liver and intestinal first-pass metabolism of flavonoid baicalein
Li Zhang et al.
PHARMACEUTICAL RESEARCH (2007)
A facile synthesis of isoflavone 7-O-glucuronides
Nawaf Al-Maharik et al.
TETRAHEDRON LETTERS (2006)
The importance of local chemical structure for chemical metabolism by human uridine 5′-diphosphate -: Glucuronosyltransferase
Michael J. Sorich et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2006)
Disposition of flavonoids via enteric recycling: Structural effects and lack of correlations between in vitro and in situ metabolic properties
Stephen W. J. Wang et al.
DRUG METABOLISM AND DISPOSITION (2006)
Anthocyanins: Structural characteristics that result in unique metabolic patterns and biological activities
Ronald L. Prior et al.
FREE RADICAL RESEARCH (2006)
Genetic variants of human UGT1A3: Functional characterization and frequency distribution in a Chinese Han population
Yakun Chen et al.
DRUG METABOLISM AND DISPOSITION (2006)
Pharmacokinetics and metabolism of the flavonoid scutellarin in humans after a single oral administration
Xiaoyan Chen et al.
DRUG METABOLISM AND DISPOSITION (2006)
Convenient syntheses of metabolically important quercetin glucuronides and sulfates
Paul W. Needs et al.
TETRAHEDRON (2006)
Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions
William Mullen et al.
BRITISH JOURNAL OF NUTRITION (2006)
Position preference on glucuronidation of mono-hydroxylflavones in human intestine
Li Zhang et al.
LIFE SCIENCES (2006)
Methylation protects dietary flavonoids from rapid hepatic metabolism
X. Wen et al.
XENOBIOTICA (2006)
Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer
S Nagar et al.
ONCOGENE (2006)
Quantitative structure activity relationships in drug metabolism
Kamaldeep K. Chohan et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2006)
Human UDP-Glucuronosyltransferase 1A5: Identification, expression, and activity
M Finel et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily
PI Mackenzie et al.
PHARMACOGENETICS AND GENOMICS (2005)
Quantitative regioselectivity of glucuronidation of quercetin by recombinant UDP-glucuronosyltransferases 1A9 and 1A3 using enzymatic kinetic parameters
YK Chen et al.
XENOBIOTICA (2005)
In vitro phase II metabolism of xanthohumol by human UDP-glucuronosyltransferases and sulfotransferases
CE Ruefer et al.
MOLECULAR NUTRITION & FOOD RESEARCH (2005)
Stereospecific high-performance liquid chromatographic analysis of naringenin in urine
JA Yáñez et al.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2005)
In vitro biological properties of flavonoid conjugates found in vivo
G Williamson et al.
FREE RADICAL RESEARCH (2005)
A historical overview of the heterologous expression of mammalian UDP-glucuronosyltransferase isoforms over the past twenty years
A Radominska-Pandya et al.
CURRENT DRUG METABOLISM (2005)
Stereospecific high-performance liquid chromatographic analysis of hesperetin in biological matrices
JA Yáñez et al.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2005)
Glucuronidation of bioflavonoids by human UGT1A10: structure-function relationships
RH Lewinsky et al.
XENOBIOTICA (2005)
Absorption and metabolism of genistein and its five isoflavone analogs in the human intestinal Caco-2 model
J Chen et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2005)
Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake
NK Basu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Review of the flavonoids quercetin, hesperetin naringenin. Dietary sources, bioactivities, and epidemiology
I Erlund
NUTRITION RESEARCH (2004)
Regulation of UDP glucuronosyltransferases in the gastrointestinal tract
PA Gregory et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2004)
Pharmacokinetics and metabolism of dietary flavonoids in humans
C Manach et al.
FREE RADICAL RESEARCH (2004)
Properties of quercetin conjugates: Modulation of LDL oxidation and binding to human serum albumin
KM Janisch et al.
FREE RADICAL RESEARCH (2004)
Flavonoids and the brain: Interactions at the blood-brain barrier and their physiological effects on the central nervous system
KA Youdim et al.
FREE RADICAL BIOLOGY AND MEDICINE (2004)
Towards integrated ADME prediction: past, present and future directions for modelling metabolism by UDP-glucuronosyltransferases
PA Smith et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2004)
Anthocyanins and other flavonoids
CA Williams et al.
NATURAL PRODUCT REPORTS (2004)
Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans
MS DuPont et al.
EUROPEAN JOURNAL OF CLINICAL NUTRITION (2004)
The relation between the chemical structure of flavonoids and their estrogen-like activities
J Vaya et al.
CURRENT MEDICINAL CHEMISTRY (2004)
Effect of quercetin conjugates on vascular permeability and expression of adhesion molecules
M Mochizuki et al.
BIOFACTORS (2004)
Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs
L Villeneuve et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
Glucuronidation activity of the UGT2B17 enzyme toward xenobiotics
D Turgeon et al.
DRUG METABOLISM AND DISPOSITION (2003)
Structures of (-)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (-)-epicatechin: Differences between human and rat
M Natsume et al.
FREE RADICAL BIOLOGY AND MEDICINE (2003)
Glucuronides of tea catechins: Enzymology of biosynthesis and biological activities
H Lu et al.
DRUG METABOLISM AND DISPOSITION (2003)
Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes
YC Shen et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2003)
Pharmacogenomics of human UDP-glucuronosyltransferase enzymes
C Guillemette
PHARMACOGENOMICS JOURNAL (2003)
Pharmacophore and quantitative structure activity relationship modelling of UDP-glucuronosyltransferase 1A1 (UGT1A1) substrates
MJ Sorich et al.
PHARMACOGENETICS (2002)
Glucuronidation and sulfation of the tea flavonoid (-)-epicatechin by the human and rat enzymes
JB Vaidyanathan et al.
DRUG METABOLISM AND DISPOSITION (2002)
QSAR aspects of flavonoids as a plentiful source of new drugs
ON Voskresensky et al.
CURRENT MEDICINAL CHEMISTRY (2002)
Quantitative structure activity relationships for the glucuronidation of simple phenols by expressed human UGT1A6 and UGT1A9
BT Ethell et al.
DRUG METABOLISM AND DISPOSITION (2002)
Regioselectivity of phase 11 metabolism of luteolin and quercetin by UDP-glucuronosyl transferases
MG Boersma et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2002)
In vitro characterization of hepatic flavopiridol metabolism using human liver microsomes and recombinant UGT enzymes
J Ramírez et al.
PHARMACEUTICAL RESEARCH (2002)
Glucuronidation versus oxidation of the flavonoid galangin by human liver microsomes and hepatocytes
Y Otake et al.
DRUG METABOLISM AND DISPOSITION (2002)
Developmental aspects of human hepatic drug glucuronidation in young children and adults
CP Strassburg et al.
GUT (2002)
Flavonoid glucuronides are substrates for human liver β-glucuronidase
KA O'Leary et al.
FEBS LETTERS (2001)
Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase
É Lévesque et al.
BIOCHEMISTRY (2001)
Syntheses of daidzein-7-yl β-D-glucopyranosiduronic acid and daidzein-4′,7-yl di-β-D-glucopyranosiduronic acid
PW Needs et al.
CARBOHYDRATE RESEARCH (2001)
Disposition and metabolism of the flavonoid chrysin in normal volunteers
T Walle et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2001)
Human metabolism of dietary flavonoids: Identification of plasma metabolites of quercetin
AJ Day et al.
FREE RADICAL RESEARCH (2001)
Conjugation position of quercetin glucuronides and effect on biological activity
AJ Day et al.
FREE RADICAL BIOLOGY AND MEDICINE (2000)