期刊
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
卷 5, 期 11, 页码 1399-1419出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/17425250903179300
关键词
flavonoids; glucuronidation; metabolism; regioselectivity; structure-activity relationships; substrate specificity; UGT
资金
- RGC [2140585]
With the increasing intake of flavonoids in diet, supplements and herbal medicines, studies on the biotransformation and disposition have been dramatically expanded. The current review covers the findings on the relationships between flavonoid structural properties and their glucuronidation activities in in vivo trials and in vitro human UGTs or microsomes for the past 2 decades. Regioselectivity and substrate specificity on the glucuronidation of flavonoids are summarized. The findings reveal the inconsistency from different studies and indicate the importance of in silico modeling in the prediction of structure-glucuronidation relationship.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据