期刊
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
卷 4, 期 4, 页码 381-393出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/17425255.4.4.381
关键词
6'7'-dihydroxybergamottin; cranberry; furanocoumarins; grapefruit; orange; pomegranate
资金
- NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE [R01AT001381, F32AT003540] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI058784] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG017880] Funding Source: NIH RePORTER
- NCCIH NIH HHS [AT-01381, AT-003540] Funding Source: Medline
- NIAID NIH HHS [AI-58784] Funding Source: Medline
- NIA NIH HHS [AG-17880] Funding Source: Medline
Background: Grapefruit juice is known to alter the pharmacokinetics of over 30 prescription drugs by increasing their bioavailabilities. After the discovery of this interaction almost 20 years ago, there have been many reports investigating the effects of fruit juices on drug disposition. Objective: This article reviews the literature on fruit juice-prescription drug interaction studies to determine which juices are likely to cause clinically significant interactions. Methods: We examined the results from in vitro and clinical studies regarding the interactions between prescription drugs and over ten fruit beverages. Results/conclusions: Grapefruit juice and Seville orange juice caused several clinically significant interactions with cytochrome P4503A (CYP3A). The OATP drug transporter was inhibited by grapefruit juice, orange juice, and apple juice. Other fruit juices also interacted with drug metabolizing enzymes and transporters in vitro, but more studies are needed to determine whether these interactions are clinically significant.
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