4.5 Review

Primary hepatocytes as a model to analyze species-specific toxicity and drug metabolism

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Medicinal

Idiosyncratic drug reactions: Past, present, and future

Jack Uetrecht

CHEMICAL RESEARCH IN TOXICOLOGY (2008)

Article Cell & Tissue Engineering

Engineered liver-like tissue on a capillarized matrix for applied research

Kirstin Linke et al.

TISSUE ENGINEERING (2007)

Article Biochemistry & Molecular Biology

Human hepatocytes: Isolation, cryopreservation and applications in drug development

Albert P. Li

CHEMICO-BIOLOGICAL INTERACTIONS (2007)

Review Chemistry, Medicinal

Applying mechanisms of chemical toxicity to predict drug safety

F. Peter Guengerich et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2007)

Article Biochemistry & Molecular Biology

Acetaminophen-induced hepatotoxicity of gel entrapped rat hepatocytes in hollow fibers

Chong Shen et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2006)

Article Cell & Tissue Engineering

Hepatocyte and Kupffer cells co-cultured on micropatterned surfaces to optimize hepatocyte function

Yekaterina S. Zinchenko et al.

TISSUE ENGINEERING (2006)

Review Public, Environmental & Occupational Health

A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: lessons learned from the bromfenac experience

L Goldkind et al.

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY (2006)

Article Pharmacology & Pharmacy

Use of cryopreserved human hepatocytes in sandwich culture to measure hepatobiliary transport

Yi-an Bi et al.

DRUG METABOLISM AND DISPOSITION (2006)

Review Pharmacology & Pharmacy

Cytomics as a new potential for drug discovery

Guenter Valet

DRUG DISCOVERY TODAY (2006)

Article Pharmacology & Pharmacy

Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells

C Aninat et al.

DRUG METABOLISM AND DISPOSITION (2006)

Review Biochemistry & Molecular Biology

A microscale in vitro physiological model of the liver:: Predictive screens for drug metabolism and enzyme induction

A Sivaraman et al.

CURRENT DRUG METABOLISM (2005)

Article Engineering, Biomedical

Engineering of a vascularized scaffold for artificial tissue and organ generation

H Mertsching et al.

BIOMATERIALS (2005)

Article Biochemical Research Methods

Systems cell biology knowledge created from high content screening

KA Giuliano et al.

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2005)

Review Biotechnology & Applied Microbiology

Idiosyncratic drug hepatotoxicity

N Kaplowitz

NATURE REVIEWS DRUG DISCOVERY (2005)

Review Biochemistry & Molecular Biology

In vitro methods to study chemically-induced hepatotoxicity:: A literature review

D Farkas et al.

CURRENT DRUG METABOLISM (2005)

Article Biotechnology & Applied Microbiology

Cutting the cost of drug development?

MD Rawlins

NATURE REVIEWS DRUG DISCOVERY (2004)

Article Gastroenterology & Hepatology

Origin and characterization of a human bipotent liver progenitor cell line

R Parent et al.

GASTROENTEROLOGY (2004)

Article Environmental Sciences

Database development in toxicogenomics: Issues and efforts

WB Mattes et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2004)

Article Immunology

Drug-induced liver injury

N Kaplowitz

CLINICAL INFECTIOUS DISEASES (2004)

Article Pharmacology & Pharmacy

Phase I and II enzyme characterization of two sources of HepG2 cell lines

NJ Hewitt et al.

XENOBIOTICA (2004)

Article Gastroenterology & Hepatology

Liver transplantation for acute liver failure from drug induced liver injury in the United States

MW Russo et al.

LIVER TRANSPLANTATION (2004)

Article Toxicology

Characteristic expression profiles induced by genotoxic carcinogens in rat liver

H Ellinger-Ziegelbauer et al.

TOXICOLOGICAL SCIENCES (2004)

Article Biochemistry & Molecular Biology

Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential

JJ Xu et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2004)

Article Biochemistry & Molecular Biology

Organ slices for the evaluation of human drug toxicity

AEM Vickers et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2004)

Review Biochemistry & Molecular Biology

Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor

PE Ganey et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2004)

Article Pharmacology & Pharmacy

Metabolic activation of troglitazone: Identification of a reactive metabolite and mechanisms involved

K He et al.

DRUG METABOLISM AND DISPOSITION (2004)

Review Biotechnology & Applied Microbiology

High content screening applied to large-scale cell biology

VC Abraham et al.

TRENDS IN BIOTECHNOLOGY (2004)

Article Pharmacology & Pharmacy

Acetaminophen-induced hepatotoxicity

LP James et al.

DRUG METABOLISM AND DISPOSITION (2003)

Review Pharmacology & Pharmacy

Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity

UA Boelsterli

TOXICOLOGY AND APPLIED PHARMACOLOGY (2003)

Review Biochemistry & Molecular Biology

The metabolism of diclofenac - Enzymology and toxicology perspectives

W Tang

CURRENT DRUG METABOLISM (2003)

Review Biochemical Research Methods

Advances in high content screening for drug discovery

KA Giuliano et al.

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2003)

Review Medicine, General & Internal

Medical progress: Drug-induced hepatotoxicity

WM Lee

NEW ENGLAND JOURNAL OF MEDICINE (2003)

Review Pharmacology & Pharmacy

An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons

EFA Brandon et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2003)

Review Chemistry, Medicinal

Mechanisms of troglitazone hepatotoxicity

MT Smith

CHEMICAL RESEARCH IN TOXICOLOGY (2003)

Article Pharmacology & Pharmacy

Streptozotocin-induced diabetic mice are resistant to lethal effects of thioacetamide hepatotoxicity

K Shankar et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2003)

Article Economics

The price of innovation: new estimates of drug development costs

JA DiMasi et al.

JOURNAL OF HEALTH ECONOMICS (2003)

Article Multidisciplinary Sciences

Infection of a human hepatoma cell line by hepatitis B virus

P Gripon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Toxicology

Biology and toxicology of PPARγ ligands

JD Tugwood et al.

HUMAN & EXPERIMENTAL TOXICOLOGY (2002)

Article Gastroenterology & Hepatology

Drug-induced liver disease

JH Lewis

CURRENT OPINION IN GASTROENTEROLOGY (2002)

Review Pathology

In vitro models to study hepatotoxicity

DA Groneberg et al.

TOXICOLOGIC PATHOLOGY (2002)

Article Toxicology

Forum - Mechanisms of hepatotoxicity

H Jaeschke et al.

TOXICOLOGICAL SCIENCES (2002)

Review Biochemical Research Methods

Real-time molecular and cellular analysis: the new frontier of drug discovery

DL Taylor et al.

CURRENT OPINION IN BIOTECHNOLOGY (2001)

Article Public, Environmental & Occupational Health

Drug-induced liver disorders - Implications for drug development and regulation

N Kaplowitz

DRUG SAFETY (2001)

Article Medicine, Legal

Concordance of the toxicity of pharmaceuticals in humans and in animals

H Olson et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2000)

Article Pharmacology & Pharmacy

Enhanced hepatotoxicity and toxic outcome of thioacetamide in streptozotocin-induced diabetic rats

T Wang et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2000)

Article Gastroenterology & Hepatology

Mechanisms of liver cell injury

N Kaplowitz

JOURNAL OF HEPATOLOGY (2000)