相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。t-PA, but not desmoteplase, induces plasmin-dependent opening of a blood-brain barrier model under normoxic and ischaemic conditions
Roxann Freeman et al.
BRAIN RESEARCH (2014)
Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review
Joana Bicker et al.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2014)
Quantitative targeted proteomics for understanding the blood-brain barrier: towards pharmacoproteomics
Sumio Ohtsuki et al.
EXPERT REVIEW OF PROTEOMICS (2014)
Neonatal Fc receptor (FcRn): a novel target for therapeutic antibodies and antibody engineering
Yuan Wang et al.
JOURNAL OF DRUG TARGETING (2014)
Instruction of Circulating Endothelial Progenitors In Vitro towards Specialized Blood-Brain Barrier and Arterial Phenotypes
Julie Boyer-Di Ponio et al.
PLOS ONE (2014)
A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells
Romeo Cecchelli et al.
PLOS ONE (2014)
Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery
Irena Loryan et al.
PHARMACEUTICAL RESEARCH (2014)
Zebrafish approaches enhance the translational research tackle box
Michael A. Pickart et al.
TRANSLATIONAL RESEARCH (2014)
Zebrafish models for translational neuroscience research: from tank to bedside
Adam Michael Stewart et al.
TRENDS IN NEUROSCIENCES (2014)
A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources
Ethan S. Lippmann et al.
SCIENTIFIC REPORTS (2014)
GRL-04810 and GRL-05010, Difluoride-Containing Nonpeptidic HIV-1 Protease Inhibitors (PIs) That Inhibit the Replication of Multi-PI-Resistant HIV-1 In Vitro and Possess Favorable Lipophilicity That May Allow Blood-Brain Barrier Penetration
Pedro Miguel Salcedo Gomez et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)
BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function
L. M. Griep et al.
BIOMEDICAL MICRODEVICES (2013)
A new dynamic in vitro modular capillaries-venules modular system: Cerebrovascular physiology in a box
Luca Cucullo et al.
BMC NEUROSCIENCE (2013)
Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitro models of the rat blood-brain barrier and blood-spinal cord barrier
P. Marc D. Watson et al.
BMC NEUROSCIENCE (2013)
Establishment of a simplified in vitro porcine blood-brain barrier model with high transendothelial electrical resistance
Adjanie Patabendige et al.
BRAIN RESEARCH (2013)
'Sealing off the CNS': cellular and molecular regulation of blood-brain barriergenesis
Julie A. Siegenthaler et al.
CURRENT OPINION IN NEUROBIOLOGY (2013)
Retinoic Acid Induces Blood-Brain Barrier Development
Mark R. Mizee et al.
JOURNAL OF NEUROSCIENCE (2013)
Multiplexed Evaluation of Serum and CSF Pharmacokinetics of Brain-Targeting Single-Domain Antibodies Using a NanoLC-SRM-ILIS Method
Arsalan S. Haqqani et al.
MOLECULAR PHARMACEUTICS (2013)
Diffusion of Macromolecules in the Brain: Implications for Drug Delivery
Daniel J. Wolak et al.
MOLECULAR PHARMACEUTICS (2013)
Development, maintenance and disruption of the blood-brain barrier
Birgit Obermeier et al.
NATURE MEDICINE (2013)
Phase II and Phase III attrition rates 2011-2012
John Arrowsmith et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
Wnt Activation of Immortalized Brain Endothelial Cells as a Tool for Generating a Standardized Model of the Blood Brain Barrier In Vitro
Roberta Paolinelli et al.
PLOS ONE (2013)
Functional Characterisation of the Maturation of the Blood-Brain Barrier in Larval Zebrafish
Angeleen Fleming et al.
PLOS ONE (2013)
Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier
Jessica A. Couch et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Laminin isoforms in endothelial and perivascular basement membranes
Lema F. Yousif et al.
CELL ADHESION & MIGRATION (2013)
The hCMEC/D3 cell line as a model of the human blood brain barrier
Babette Weksler et al.
FLUIDS AND BARRIERS OF THE CNS (2013)
Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood-brain barrier model for drug permeability studies
Daniela E. Eigenmann et al.
FLUIDS AND BARRIERS OF THE CNS (2013)
In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish
Kohei Watanabe et al.
BMC NEUROSCIENCE (2012)
Zebrafish as a Model to Study Drug Transporters at the Blood-Brain Barrier
R. A. Umans et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2012)
In Vitro Modeling of the Blood-Brain Barrier: Simplicity Versus Complexity
Omolara O. Ogunshola
CURRENT PHARMACEUTICAL DESIGN (2012)
Imaging blood-brain barrier dysfunction in animal disease models
Andreas Wunder et al.
EPILEPSIA (2012)
Comparison of brain capillary endothelial cell-based and epithelial (MDCK-MDR1, Caco-2, and VB-Caco-2) cell-based surrogate blood-brain barrier penetration models
Eve Hellinger et al.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2012)
CNS Drug Development - Lost in Translation?
A. Talevi et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2012)
Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)
Ross Booth et al.
LAB ON A CHIP (2012)
Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells
Ethan S. Lippmann et al.
NATURE BIOTECHNOLOGY (2012)
Galanin Transgenic Mice with Elevated Circulating Galanin Levels Alleviate Demyelination in a Cuprizone-Induced MS Mouse Model
Lin Zhang et al.
PLOS ONE (2012)
Transcriptional Profiling of Human Brain Endothelial Cells Reveals Key Properties Crucial for Predictive In Vitro Blood-Brain Barrier Models
Eduard Urich et al.
PLOS ONE (2012)
How well can in vitro brain microcapillary endothelial cell models predict rodent in vivo blood-brain barrier permeability?
Alex Avdeef
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2011)
Physiologic and Anatomic Characterization of the Brain Surface Glia Barrier of Drosophila
Michael K. Desalvo et al.
GLIA (2011)
Peripheral Nerve Pericytes Modify the Blood-Nerve Barrier Function and Tight Junctional Molecules Through the Secretion of Various Soluble Factors
Fumitaka Shimizu et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2011)
Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors
Yasuo Uchida et al.
JOURNAL OF NEUROCHEMISTRY (2011)
Engaging neuroscience to advance translational research in brain barrier biology
Edward A. Neuwelt et al.
NATURE REVIEWS NEUROSCIENCE (2011)
Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target
Y. Joy Yu et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
Claudin-5a in developing zebrafish brain barriers: Another brick in the wall
Salim Abdelilah-Seyfried
BIOESSAYS (2010)
Validation of In Vitro Cell-Based Human Blood Brain Barrier Model Using Clinical Positron Emission Tomography Radioligands To Predict In Vivo Human Brain Penetration
Aloise Mabondzo et al.
MOLECULAR PHARMACEUTICS (2010)
Structure and function of the blood-brain barrier
N. Joan Abbott et al.
NEUROBIOLOGY OF DISEASE (2010)
Control of the Blood-Brain Barrier by Glucocorticoids and the Cells of the Neurovascular Unit
Susanne Kroell et al.
MOLECULAR STRUCTURE AND FUNCTION OF THE TIGHT JUNCTION: FROM BASIC MECHANISMS TO CLINICAL MANIFESTATIONS (2009)
A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes
Shinsuke Nakagawa et al.
NEUROCHEMISTRY INTERNATIONAL (2009)
CSF as a surrogate for assessing CNS exposure: An industrial perspective
Jiunn H. Lin
CURRENT DRUG METABOLISM (2008)
An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening
Maxime Culot et al.
TOXICOLOGY IN VITRO (2008)
Dynamic Analysis of the Blood-Brain Barrier Disruption in Experimental Stroke Using Time Domain In Vivo Fluorescence Imaging
Abedelnasser Abulrob et al.
MOLECULAR IMAGING (2008)
Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies
Luca Cucullo et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2008)
On the rate and extent of drug delivery to the brain
Margareta Hammarlund-Udenaes et al.
PHARMACEUTICAL RESEARCH (2008)
Pericytes from brain microvessels strengthen the barrier integrity in primary cultures of rat brain endothelial cells
Shinsuke Nakagawa et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2007)
Drug development for CNS disorders: strategies for balancing risk and reducing attrition
Menelas N. Pangalos et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
The impact of glia-derived extracellular matrices on the barrier function of cerebral endothelial cells:: An in vitro study
Christoph Hartmann et al.
EXPERIMENTAL CELL RESEARCH (2007)
Drug targeting to the brain
William M. Pardridge
PHARMACEUTICAL RESEARCH (2007)
Blood-brain barrier transport of therapeutics via receptor-mediation
Angela R. Jones et al.
PHARMACEUTICAL RESEARCH (2007)
Methods to assess drug permeability across the blood-brain barrier
JA Nicolazzo et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2006)
Astrocyte-endothelial interactions at the blood-brain barrier
NJ Abbott et al.
NATURE REVIEWS NEUROSCIENCE (2006)
The critical component to establish in vitro BBB model: Pericyte
CH Lai et al.
BRAIN RESEARCH REVIEWS (2005)
The blood-brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells
A Abulrob et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Quantitation and localization of blood-to-brain influx by magnetic resonance imaging and quantitative autoradiography in a model of transient focal ischemia
RA Knight et al.
MAGNETIC RESONANCE IN MEDICINE (2005)
Mouse syngenic in vitro blood-brain barrier model:: a new tool to examine inflammatory events in cerebral endothelium
C Coisne et al.
LABORATORY INVESTIGATION (2005)
In vitro models for the blood-brain barrier
P Garberg et al.
TOXICOLOGY IN VITRO (2005)
Blood-brain barrier-specific properties of a human adult brain endothelial cell line
BB Weksler et al.
FASEB JOURNAL (2005)
Dynamics of CNS barriers: Evolution, differentiation, and modulation
NJ Abbott
CELLULAR AND MOLECULAR NEUROBIOLOGY (2005)
Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology
NJ Abbott
NEUROCHEMISTRY INTERNATIONAL (2004)
Involvement of P-glycoprotein in blood-brain barrier transport of pentazocine in rats using brain uptake index method
Y Moriki et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2004)
Prediction of drug transport through the blood-brain barrier in vivo:: A comparison between two in vitro cell models
S Lundquist et al.
PHARMACEUTICAL RESEARCH (2002)
Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting - Implications of the barriers between blood and brain
ECM de Lange et al.
CLINICAL PHARMACOKINETICS (2002)
Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium
A Muruganandam et al.
FASEB JOURNAL (2001)
Bacterial invasion and transcytosis in transfected human brain microvascular endothelial cells
MF Stins et al.
MICROBIAL PATHOGENESIS (2001)
The use of microdialysis in CNS drug delivery studies - Pharmacokinetic perspectives and results with analgesics and antiepileptics
M Hammarlund-Udenaes
ADVANCED DRUG DELIVERY REVIEWS (2000)