4.5 Review

The importance of synthetic drugs for type 2 diabetes drug discovery

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Pharmacology & Pharmacy

The Efficacy and Tolerability of Exenatide in Comparison to Placebo; A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Shekoufeh Nikfar et al.

JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES (2016)

Article Biochemistry & Molecular Biology

A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site

Mika Nabeno et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Article Peripheral Vascular Disease

Advances in Pharmacologic Therapies for Type 2 Diabetes

Linde M. Morsink et al.

CURRENT ATHEROSCLEROSIS REPORTS (2013)

Article Pharmacology & Pharmacy

Sirtuins as Possible Drug Targets in Type 2 Diabetes

Munehiro Kitada et al.

CURRENT DRUG TARGETS (2013)

Review Urology & Nephrology

Connective tissue growth factor, matrix regulation, and diabetic kidney disease

Susan V. McLennan et al.

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2013)

Article Endocrinology & Metabolism

Dipeptidyl peptidase-4 inhibitors and angioedema: a class effect?

Y. Saisho et al.

DIABETIC MEDICINE (2013)

Article Pharmacology & Pharmacy

Canagliflozin: First Global Approval

Shelley Elkinson et al.

Review Pharmacology & Pharmacy

Gliptins (dipeptidyl peptidase-4 inhibitors) and risk of acute pancreatitis

Andre Scheen

EXPERT OPINION ON DRUG SAFETY (2013)

Review Pharmacology & Pharmacy

Effect of Chromium on Glucose and Lipid Profiles in Patients with Type 2 Diabetes; A Meta-analysis Review of Randomized Trials

Amir Farshchi et al.

JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES (2013)

Article Multidisciplinary Sciences

Structure of the human glucagon class B G-protein-coupled receptor

Fai Yiu Siu et al.

NATURE (2013)

Article Medicine, General & Internal

Glucose Levels and Risk of Dementia

Paul K. Crane et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Medicine, General & Internal

Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes

Rena Wing et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Chemistry, Multidisciplinary

CoMFA and CoMSIA studies on C-aryl glucoside SGLT2 inhibitors as potential anti-diabetic agents

V. K. Vyas et al.

SAR AND QSAR IN ENVIRONMENTAL RESEARCH (2013)

Review Pharmacology & Pharmacy

Pesticides and human chronic diseases: Evidences, mechanisms, and perspectives

Sara Mostafalou et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2013)

Article Pharmacology & Pharmacy

Pancreatitis: A Potential Complication of Liraglutide?

Andrea S. Franks et al.

ANNALS OF PHARMACOTHERAPY (2012)

Article Biochemistry & Molecular Biology

Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors

Yohei Ikuma et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2012)

Article Chemistry, Medicinal

Discovery of potent, selective and orally bioavailable triaryl-sulfonamide based PTP1B inhibitors

Dipam Patel et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

Article Chemistry, Medicinal

Synthesis and biological evaluation of novel C-indolylxylosides as sodium-dependent glucose co-transporter 2 inhibitors

Chun-Hsu Yao et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)

Editorial Material Pharmacology & Pharmacy

It is Time to Formulate an Antioxidant Mixture for Management of Diabetes and its Complications: Notice for Pharmaceutical Industries

Asieh Hosseini et al.

INTERNATIONAL JOURNAL OF PHARMACOLOGY (2012)

Review Pharmacology & Pharmacy

SGLT2 Inhibitors: A New Emerging Therapeutic Class in the Treatment of Type 2 Diabetes Mellitus

Raktim Kumar Ghosh et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2012)

News Item Biotechnology & Applied Microbiology

SGLT2 inhibitors race to enter type-2 diabetes market

Cormac Sheridan

NATURE BIOTECHNOLOGY (2012)

Review Pharmacology & Pharmacy

Targeting the glucagon receptor family for diabetes and obesity therapy

Young Min Cho et al.

PHARMACOLOGY & THERAPEUTICS (2012)

Article Pharmacology & Pharmacy

Effect of chicory seed extract on glucose tolerance test (GTT) and metabolic profile in early and late stage diabetic rats

Abdolreza Ghamarian et al.

DARU-JOURNAL OF PHARMACEUTICAL SCIENCES (2012)

Review Veterinary Sciences

Recent Update on Animal and Human Evidences of Promising Anti-diabetic Medicinal Plants: A Mini-review of Targeting New Drugs

Shirin Hasani Ranjbar et al.

ASIAN JOURNAL OF ANIMAL AND VETERINARY ADVANCES (2011)

Article Biochemistry & Molecular Biology

Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554

Hironobu Maezaki et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2011)

Article Chemistry, Medicinal

Synthesis and antigastric ulcer activity of novel 5-isoproyl-3,8-dimethylazulene derivatives

Lu-Yun Zhang et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)

Review Endocrinology & Metabolism

Use of Metformin in the Setting of Mild-to-Moderate Renal Insufficiency

Kasia J. Lipska et al.

DIABETES CARE (2011)

Review Pharmacology & Pharmacy

Small molecule dipeptidylpeptidase IV inhibitors under investigation for diabetes mellitus therapy

Baptist Gallwitz

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2011)

Review Chemistry, Medicinal

Software and resources for computational medicinal chemistry

Chenzhong Liao et al.

FUTURE MEDICINAL CHEMISTRY (2011)

Review Pharmacology & Pharmacy

A Review of the Potential Benefits of Pentoxifylline in Diabetic and Non-Diabetic Proteinuria

Shirinsadat Badri et al.

JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES (2011)

Review Urology & Nephrology

SGLT2 inhibitors: molecuar design and potential differences in effect

Masayuki Isaji

KIDNEY INTERNATIONAL (2011)

Article Endocrinology & Metabolism

Development and potential role of type-2 sodium-glucose transporter inhibitors for management of type 2 diabetes

Timothy Colin Hardman et al.

Diabetes Therapy (2011)

Article Ophthalmology

Role of β-Adrenergic Receptor Regulation of TNF-α and Insulin Signaling in Retinal Muller Cells

Robert J. Walker et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2011)

Article Chemistry, Medicinal

Synthesis and SAR of azolopyrimidines as potent and selective dipeptidyl peptidase-4 (DPP4) inhibitors for type 2 diabetes

Robert P. Brigance et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)

Article Chemistry, Medicinal

Novel azulene-based derivatives as potent multi-receptor tyrosine kinase inhibitors

Chih-Hung Chen et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)

Article Chemistry, Multidisciplinary

Thiadiazole-based Thioglycosides as Sodium-glucose Co-transporter 2 (SGLT2) Inhibitors

Gao Yunlong et al.

CHINESE JOURNAL OF CHEMISTRY (2010)

Article Endocrinology & Metabolism

The Genetics of Insulin Resistance: Where's Waldo?

Richard M. Watanabe

CURRENT DIABETES REPORTS (2010)

Article Integrative & Complementary Medicine

Effects of Satureja khuzestanica on Serum Glucose, Lipids and Markers of Oxidative Stress in Patients with Type 2 Diabetes Mellitus: A Double-Blind Randomized Controlled Trial

Sanaz Vosough-Ghanbari et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2010)

Editorial Material Medicine, General & Internal

Weighing Risks and Benefits of Liraglutide -- The FDA's Review of a New Antidiabetic Therapy.

Mary Parks et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Review Medicine, General & Internal

GENOMIC MEDICINE Genomics, Type 2 Diabetes, and Obesity

Mark I. McCarthy

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Physiology

Oxidative stress and beta-cell dysfunction

Gisela Drews et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2010)

Article Chemistry, Organic

Syntheses of C-5-spirocyclic C-glycoside SGLT2 inhibitors

Vincent Mascitti et al.

TETRAHEDRON LETTERS (2010)

Review Chemistry, Medicinal

Liraglutide in the management of type 2 diabetes

Estela Wajcberg et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2010)

Article Endocrinology & Metabolism

Bromocriptine approved as the first medication to target dopamine activity to improve glycemic control in patients with type 2 diabetes

Via

Diabetes Metabolic Syndrome and Obesity-Targets and Therapy (2010)

Review Medicine, Research & Experimental

Saxagliptin: a new DPP-4 inhibitor for the treatment of type 2 diabetes mellitus

Abd A. Tahrani et al.

ADVANCES IN THERAPY (2009)

Review Biochemistry & Molecular Biology

Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes

Shrikanth H. Havale et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2009)

Article Endocrinology & Metabolism

Does glucagon-like peptide-1 receptor agonist therapy add value in the treatment of type 2 diabetes? Focus on exenatide

Renate E. van Genugten et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2009)

Review Cell Biology

The incretin system and its role in type 2 diabetes mellitus

Jens Juul Holst et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2009)

Article Gastroenterology & Hepatology

Islet transplantation and antioxidant management: A comprehensive review

Seyed Sajad Mohseni Salehi Monfared et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2009)

Article Chemistry, Medicinal

3,5-dihydro-imidazo[4,5-d]pyridazin-4-ones:: A class of potent DPP-4 inhibitors

Matthias Eckhardt et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)

Article Cardiac & Cardiovascular Systems

New drugs for the treatment of diabetes - Part II: Incretin-based therapy and beyond

Silvio E. Inzucchi et al.

CIRCULATION (2008)

Editorial Material Medicine, General & Internal

Rosiglitazone no longer recommended

[Anonymous]

LANCET (2008)

Review Endocrinology & Metabolism

Glucolipotoxicity:: Fuel excess and β-cell dysfunction

Vincent Poitout et al.

ENDOCRINE REVIEWS (2008)

Article Pharmacology & Pharmacy

Pharmacological profile of ASP8497, a novel, selective, and competitive dipeptidyl peptidase-IV inhibitor, in vitro and in vivo

Yuka Someya et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2008)

Article Medicine, General & Internal

10-year follow-up of intensive glucose control in type 2 diabetes

Rury R. Holman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Review Pharmacology & Pharmacy

The Role of Incretins in Glucose Homeostasis and Diabetes Treatment

Wook Kim et al.

PHARMACOLOGICAL REVIEWS (2008)

Article Biochemistry & Molecular Biology

Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formation

William J. Metzler et al.

PROTEIN SCIENCE (2008)

Article Endocrinology & Metabolism

Diagnosis and classification of diabetes mellitus

DIABETES CARE (2008)

Article Chemistry, Medicinal

Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes

Ping Chen et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)

Review Physiology

The physiology of glucagon-like peptide 1

Jens Juul Holst

PHYSIOLOGICAL REVIEWS (2007)

Article Endocrinology & Metabolism

The DPP-4 inhibitor vildagliptin: robust glycaemic control in type 2 diabetes and beyond

G. Panina

DIABETES OBESITY & METABOLISM (2007)

Article Chemistry, Medicinal

Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors

Jason M. Cox et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)

Article Chemistry, Medicinal

[(S)-γ-(4-Aryl-1-piperazinyl)-L-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors

Tomohiro Yoshida et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)

Article Biochemistry & Molecular Biology

Lead optimization of [(S)-γ-(arylamino)prolyl]thiazolidine focused on γ-substituent:: Indoline compounds as potent DPP-IV inhibitors

Hiroshi Sakashita et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Homology models of dipeptidyl peptidases 8 and 9 with a focus on loop predictions near the active site

Christian Rummey et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2007)

Article Medicine, General & Internal

Active sugar transport in health and disease

E. M. Wright et al.

JOURNAL OF INTERNAL MEDICINE (2007)

Review Pharmacology & Pharmacy

Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity

Toshiyasu Sasaoka et al.

PHARMACOLOGY & THERAPEUTICS (2006)

Review Medicine, General & Internal

DPP-4 inhibitors and their potential role in the management of type 2 diabetes

A. Barnett

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2006)

Review Medicine, Research & Experimental

Islet β cell failure in type 2 diabetes

Marc Prentki et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Biochemistry & Molecular Biology

[(S)-γ-(arylamino)proly]thiazolidine compounds as a novel series of potent and stable DPP-IV inhibitors

Hiroshi Sakashita et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2006)

Article Endocrinology & Metabolism

The place of sulfonylureas in the therapy for type 2 diabetes mellitus

S Del Prato et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2006)

Review Cell Biology

Critical nodes in signalling pathways: insights into insulin action

CM Taniguchi et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Article Chemistry, Medicinal

Pharmacophoric features of biguanide derivatives: An electronic and structural analysis

PV Bharatam et al.

JOURNAL OF MEDICINAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

S Cinti et al.

JOURNAL OF LIPID RESEARCH (2005)

Article Medicine, General & Internal

Nateglinide - current and future role in the treatment of patients with type 2 diabetes mellitus

IW Campbell

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2005)

Article Biochemistry & Molecular Biology

The pharmacology of the insulinomimetic effect of zinc complexes

H Sakurai et al.

BIOMETALS (2005)

Review Medicine, Research & Experimental

A review on the role of antioxidants in the management of diabetes and its complications

R Rahimi et al.

BIOMEDICINE & PHARMACOTHERAPY (2005)

Article Chemistry, Medicinal

Discovery of potent and selective orally bioavailable β-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors

SD Edmondson et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)

Article Biochemistry & Molecular Biology

Synthesis and insulin-mimetic activities of metal complexes with 3-hydroxypyridine-2-carboxylic acid

M Nakai et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2005)

Article Chemistry, Medicinal

Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors

JY Xu et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)

Article Biochemistry & Molecular Biology

Reduction of diabetes-induced oxidative stress by phosphodiesterase inhibitors in rats

E Milani et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY (2005)

Review Medicine, General & Internal

Drug therapy: Insulin analogues

IB Hirsch

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Review Pharmacology & Pharmacy

Insulin secretagogues, sulfonylurea receptors and K-ATP channels

J Bryan et al.

CURRENT PHARMACEUTICAL DESIGN (2005)

Review Pharmacology & Pharmacy

Sulfonylurea treatment of type 2 diabetes mellitus: Focus on glimepiride

MT Korytkowski

PHARMACOTHERAPY (2004)

Article Chemistry, Medicinal

4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors

ER Parmee et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)

Review Medicine, General & Internal

Drug therapy: Thiazolidinediones

H Yki-Jarvinen

NEW ENGLAND JOURNAL OF MEDICINE (2004)

Article Nutrition & Dietetics

Adipokines: inflammation and the pleiotropic role of white adipose tissue

P Trayhurn et al.

BRITISH JOURNAL OF NUTRITION (2004)

Article Endocrinology & Metabolism

Repaglinide versus nateglinide monotherapy - A randomized multicenter study

J Rosenstock et al.

DIABETES CARE (2004)

Article Biochemistry & Molecular Biology

Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone

C Lagathu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)

Article Endocrinology & Metabolism

Differential selectivity of insulin secretagogues - Mechanisms, clinical implications, and drug interactions

FM Gribble et al.

JOURNAL OF DIABETES AND ITS COMPLICATIONS (2003)

Article Endocrinology & Metabolism

Impairment of myocardial protection in type 2 diabetic patients

TM Lee et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)

Article Biochemistry & Molecular Biology

Role of adiponectin in preventing vascular stenosis - The missing link of adipo-vascular axis

M Matsuda et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Review Endocrinology & Metabolism

IRS proteins and the common path to diabetes

MF White

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2002)

Article Chemistry, Medicinal

Synthesis of new azulene derivatives and study of their effect on lipid peroxidation and lipoxygenase activity

E Rekka et al.

CHEMICAL & PHARMACEUTICAL BULLETIN (2002)

Article Medicine, General & Internal

Insulinotropic meglitinide analogues

A Dornhorst

LANCET (2001)

Article Medicine, Research & Experimental

Role of AMP-activated protein kinase in mechanism of metformin action

GC Zhou et al.

JOURNAL OF CLINICAL INVESTIGATION (2001)

Article Endocrinology & Metabolism

Insulinotropic actions of exendin-4 and glucagon-like peptide-1 in vivo and in vitro

DG Parkes et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2001)

Article Endocrinology & Metabolism

Mechanism by which metformin reduces glucose production in type 2 diabetes

RS Hundal et al.

DIABETES (2000)

Review Endocrinology & Metabolism

Novel sulfonylurea and non-sulfonylurea drugs to promote the secretion of insulin

R Perfetti et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2000)

Article Medicine, Research & Experimental

Signaling pathways in insulin action: molecular targets of insulin resistance

JE Pessin et al.

JOURNAL OF CLINICAL INVESTIGATION (2000)