相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In Vivo
Scott D. Mills et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Exploiting bacterial DNA gyrase as a drug target: current state and perspectives
Frederic Collin et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2011)
New antimicrobial agents on the horizon
Karen Bush et al.
BIOCHEMICAL PHARMACOLOGY (2011)
Discovery of bacterial NAD+-dependent DNA ligase inhibitors: Optimization of antibacterial activity
Suzanne S. Stokes et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Exploring Left-Hand-Side substitutions in the benzoxazinone series of 4-amino-piperidine bacterial type IIa topoisomerase inhibitors
Bolin Geng et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases
Timothy J. Miles et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases
Timothy J. Miles et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics
Silke Alt et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2011)
Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II: Broad-Spectrum Antibacterial Agents with Reduced hERG Activity
Folkert Reck et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
A New DNA Gyrase Inhibitor Subclass of the Cyclothialidine Family Based on a Bicyclic Dilactam-Lactone Scaffold. Synthesis and Antibacterial Properties
Peter Angehrn et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Challenges of antibacterial discovery revisited
Michael N. Gwynn et al.
ANTIMICROBIAL THERAPEUTICS REVIEWS (2010)
The role of ATP in the reactions of type II DNA topoisomerases
Andrew D. Bates et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2010)
SnapShot: The Replisome
Nina Y. Yao et al.
CELL (2010)
Structural biology in fragment-based drug design
Christopher W. Murray et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2010)
Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death
Xiuhong Wang et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2010)
Type IIA topoisomerase inhibition by a new class of antibacterial agents
Benjamin D. Bax et al.
NATURE (2010)
How antibiotics kill bacteria: from targets to networks
Michael A. Kohanski et al.
NATURE REVIEWS MICROBIOLOGY (2010)
Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance
Alexandre Wohlkonig et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases
Ivan Laponogov et al.
PLOS ONE (2010)
Structure of the adenylation domain of NAD+-dependent DNA ligase from Staphylococcus aureus
Seungil Han et al.
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2009)
Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases
Daniel Aiello et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
DNA Ligases: Progress and Prospects
Stewart Shuman
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
Ivan Laponogov et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Biological activities of novel gyrase inhibitors of the aminocoumarin class
Christine Anderle et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors
Alita A. Miller et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Mechanism of action of the antibiotic NXL101, a novel nonfluoroquinolone inhibitor of bacterial type II topoisomerases
Michael T. Black et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones
Kim M. Hutchings et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
New DNA Polymerase IIIC Inhibitors: 3-Subtituted Anilinouracils with Potent Antibacterial Activity in vitro and in vivo
Niels Svenstrup et al.
CHEMMEDCHEM (2008)
Recent advances in bacterial topoisomerase inhibitors
Barton J. Bradbury et al.
CURRENT OPINION IN PHARMACOLOGY (2008)
DNA and RNA ligases: structural variations and shared mechanisms
John M. Pascal
CURRENT OPINION IN STRUCTURAL BIOLOGY (2008)
Identification and characterization of an inhibitor specific to bacterial NAD+-dependent DNA ligases
Timothy I. Meier et al.
FEBS JOURNAL (2008)
Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: Intelligent design and evolution through the judicious use of structure-guided design and stucture-activity relationships
Paul S. Charifson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Insights into the replisome from the structure of a ternary complex of the DNA polymerase III α-subunit
Richard A. Wing et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
Staphylococcus aureus primase has higher initiation specificity, interacts with single-stranded DNA stronger, but is less stimulated by its helicase than Escherichia coli primase
Scott A. Koepsell et al.
MOLECULAR MICROBIOLOGY (2008)
Understanding how the replisome works
Kenneth J. Marians
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
Quinolone-mediated bacterial death
Karl Drlica et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
The structure of a DnaB-family replicative helicase and its interactions with primase
Ganggang Wang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
Stereoselective synthesis of the bacterial DNA primase inhibitor Sch 642305 and its C-4 epimer
Jorge Garcia-Fortanet et al.
TETRAHEDRON (2007)
Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase
Scott Bailey et al.
SCIENCE (2007)
A common mechanism of cellular death induced by bactericidal antibiotics
Michael A. Kohanski et al.
CELL (2007)
Design, synthesis, and structure-activity relationship studies of new phenolic DNA gyrase inhibitors
Thomas Luebbers et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Energy coupling in type II topoisomerases: Why do they hydrolyze ATP?
Andrew D. Bates et al.
BIOCHEMISTRY (2007)
Tetrahydroindazole inhibitors of bacterial type II topoisomerases.: Part 2:: SAR development and potency against multidrug-resistant strains
John J. M. Wiener et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Novel pyrazole derivatives as potent inhibitors of type II topoisomerases.: Part 1:: Synthesis and preliminary SAR analysis
Laurent Gomez et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Small molecule inhibitors of E-coli primase, a novel bacterial target
Atul Agarwal et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Last stop on the road to repair:: Structure of E-coli DNA ligase bound to nicked DNA-adenylate
Jayakrishnan Nandakumar et al.
MOLECULAR CELL (2007)
Concise synthesis of the bacterial DNA primase inhibitor (+)-Sch 642305
Erica M. Wilson et al.
ORGANIC LETTERS (2007)
Breakage-Reunion Domain of Streptococcus pneumoniae Topoisomerase IV: Crystal Structure of a Gram-Positive Quinolone Target
Ivan Laponogov et al.
PLOS ONE (2007)
Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coli
Daniel J. Dwyer et al.
MOLECULAR SYSTEMS BIOLOGY (2007)
Structure-activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors
Tuan P. Tran et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Dual targeting of GyrB and ParE by a novel aminobenzimidazole class of antibacterial compounds
Trudy H. Grossman et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
An integrated approach to fragment-based lead generation: Philosophy, strategy and case studies from AstraZeneca's drug discovery programmes
Jeffrey S. Albert et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2007)
Replisome mechanics: insights into a twin DNA polymerase machine
Richard T. Pomerantz et al.
TRENDS IN MICROBIOLOGY (2007)
Drugs for bad bugs: confronting the challenges of antibacterial discovery
David J. Payne et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
In vitro characterization of the antibacterial spectrum of novel bacterial type II topoisomerase inhibitors of the aminobenzimidazole class
N Mani et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
Structural features of new quinolones and relationship to antibacterial activity against gram-positive bacteria
S Emami et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2006)
Isothiazoloquinolones containing functionalized aromatic hydrocarbons at the 7-position: Synthesis and in vitro activity of a series of potent antibacterial agents with diminished cytotoxicity in human cells
JA Wiles et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors
CX Zhi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Isothiazolopyridones: Synthesis, structure, and biological activity of a new class of antibacterial agents
JA Wiles et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Coupling ATP hydrolysis to DNA strand passage in type IIA DNA topoisomerases
A Maxwell et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2005)
Structure-guided mutational analysis of the nucleotidyltransferase domain of Escherichia coli NAD+-dependent DNA ligase (LigA)
H Zhu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Solution structure of the helicase-interaction domain of the primase DnaG: A model for helicase activation
K Syson et al.
STRUCTURE (2005)
Bacterial topolsomerase inhibitors: Quinolone and pyridone antibacterial agents
LA Mitscher
CHEMICAL REVIEWS (2005)
Mycobacterium tuberculosis NAD(+)-dependent DNA ligase is selectively inhibited by glycosylamines compared with human DNA ligase I
SK Srivastava et al.
NUCLEIC ACIDS RESEARCH (2005)
Mycobacterium tuberculosis DNA gyrase:: Interaction with quinolones and correlation with antimycobacterial drug activity
A Aubry et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)
New antibacterial agents derived from the DNA gyrase inhibitor cyclothialidine
P Angehrn et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Structural rearrangement accompanying NAD+ synthesis within a bacterial DNA ligase crystal
KS Gajiwala et al.
STRUCTURE (2004)
Unexpected role of 5-OH in DPPH radical-scavenging activity of 4-thiaflavans. Revealed by theoretical calculations
LF Wang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum
VR Hegde et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Isolation and structure elucidation of sch 642305, a novel bacterial DNA primase inhibitor produced by Penicillium verrucosum
M Chu et al.
JOURNAL OF NATURAL PRODUCTS (2003)
Antimycobacterial activity of 2-methyl-adenosine
EW Barrow et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2003)
Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones
H Brötz-Oesterhelt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The ATP-binding site of type II topoisomerases as a target for antibacterial drugs
A Maxwell et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2003)
An expanded view of bacterial DNA replication
MF Noirot-Gros et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Quinolone-binding pocket of DNA gyrase: Role of GyrB
J Heddle et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2002)
A second NAD+-dependent DNA ligase (LigB) in Escherichia coli
V Sriskanda et al.
NUCLEIC ACIDS RESEARCH (2001)
Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition
M Takei et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2001)
Genetic identification of two distinct DNA polymerases, DnaE and PolC, that are essential for chromosomal DNA replication in Staphylococcus aureus
R Inoue et al.
MOLECULAR GENETICS AND GENOMICS (2001)
Bacterial DNA ligases
A Wilkinson et al.
MOLECULAR MICROBIOLOGY (2001)
Crystal structure of eukaryotic DNA ligase-adenylate illuminates the mechanism of nick sensing and strand joining
M Odell et al.
MOLECULAR CELL (2000)
In vitro antimicrobial activities of novel anilinouracils which selectively inhibit DNA polymerase III of gram-positive bacteria
JS Daly et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2000)
The Protein Data Bank
HM Berman et al.
NUCLEIC ACIDS RESEARCH (2000)
分享论文
