相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL
Yan Chen Shang et al.
AGING-US (2012)
Epidemiologic Merit of Obese-Years, the Combination of Degree and Duration of Obesity
Asnawi Abdullah et al.
AMERICAN JOURNAL OF EPIDEMIOLOGY (2012)
Role of Intensive Glucose Control in Development of Renal End Points in Type 2 Diabetes Mellitus
Steven G. Coca et al.
ARCHIVES OF INTERNAL MEDICINE (2012)
MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells
Giampietro Viola et al.
BIOCHEMICAL PHARMACOLOGY (2012)
FoxO1, the transcriptional chief of staff of energy metabolism
Stavroula Kousteni
BONE (2012)
Microarray expression analysis of genes and pathways involved in growth plate cartilage injury responses and bony repair
Carmen E. Macsai et al.
BONE (2012)
Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats
N. Deblon et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Erufosine simultaneously induces apoptosis and autophagy by modulating the Akt-mTOR signaling pathway in oral squamous cell carcinoma
Vaishali Kapoor et al.
CANCER LETTERS (2012)
Mammalian target of rapamycin signaling in diabetic cardiovascular disease
Zhao Zhong Chong et al.
CARDIOVASCULAR DIABETOLOGY (2012)
The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity
Caries Canto et al.
CELL METABOLISM (2012)
Wnt1 Inducible Signaling Pathway Protein 1 (WISP1) Blocks Neurodegeneration through Phosphoinositide 3 Kinase/Akt1 and Apoptotic Mitochondrial Signaling Involving Bad, Bax, Bim, and Bcl-xL
Shaohui Wang et al.
CURRENT NEUROVASCULAR RESEARCH (2012)
GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway
Alise Hyrskyluoto et al.
EXPERIMENTAL CELL RESEARCH (2012)
Diabetes as a chronic metabolic stressor: Causes, consequences and clinical complications
Lawrence P. Reagan
EXPERIMENTAL NEUROLOGY (2012)
SIRT1: new avenues of discovery for disorders of oxidative stress
Zhao Zhong Chong et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2012)
ERK and Akt signaling pathways are involved in advanced glycation end product-induced autophagy in rat vascular smooth muscle cells
Pengfei Hu et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2012)
Erythropoietin: New Directions for the Nervous System
Kenneth Maiese et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)
Nicotinamide-induced Mitophagy EVENT MEDIATED BY HIGH NAD+/NADH RATIO AND SIRT1 PROTEIN ACTIVATION
So-young Jang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Erythropoietin mediated bone formation is regulated by mTOR signaling
Jinkoo Kim et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2012)
GLP1-derived nonapeptide GLP1(28-36)amide protects pancreatic β-cells from glucolipotoxicity
Zhengu Liu et al.
JOURNAL OF ENDOCRINOLOGY (2012)
Autophagy in hypoxia-ischemia induced brain injury
Walter Balduini et al.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2012)
Protective Function of Nicotinamide Against Ketamine-induced Apoptotic Neurodegeneration in the Infant Rat Brain
Najeeb Ullah et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2012)
A new agonist of the erythropoietin receptor, Epobis, induces neurite outgrowth and promotes neuronal survival
Stanislava Pankratova et al.
JOURNAL OF NEUROCHEMISTRY (2012)
The Combined Deletion of S6K1 and Akt2 Deteriorates Glycemic Control in a High-Fat Diet
Caroline Treins et al.
MOLECULAR AND CELLULAR BIOLOGY (2012)
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
Congcong He et al.
NATURE (2012)
SIRT1 is required for the effects of rapamycin on high glucose-inducing mesangial cells senescence
Sifang Zhang et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2012)
Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation
F. Wang et al.
ONCOGENE (2012)
Palmitate Activates Autophagy in INS-1E β-Cells and in Isolated Rat and Human Pancreatic Islets
Luisa Martino et al.
PLOS ONE (2012)
PRAS40 Is an Integral Regulatory Component of Erythropoietin mTOR Signaling and Cytoprotection
Zhao Zhong Chong et al.
PLOS ONE (2012)
Everolimus In Patients with Subependymal Giant Cell Astrocytoma Associated with Tuberous Sclerosis Complex
Monique P. Curran
PEDIATRIC DRUGS (2012)
NAD+ depletion or PAR polymer formation: which plays the role of executioner in ischaemic cell death?
C. Siegel et al.
ACTA PHYSIOLOGICA (2011)
The Wnt/beta-catenin pathway is activated during advanced arterial aging in humans
Alexandre Marchand et al.
AGING CELL (2011)
Forkhead Homeobox Type O Transcription Factors in the Responses to Oxidative Stress
Peter Storz
ANTIOXIDANTS & REDOX SIGNALING (2011)
Diabetes mellitus abrogates erythropoietin-induced cardioprotection against ischemic-reperfusion injury by alteration of the RISK/GSK-3 beta signaling
Nehmat Ghaboura et al.
BASIC RESEARCH IN CARDIOLOGY (2011)
Nicotinamide Blocks Proliferation and Induces Apoptosis of Chronic Lymphocytic Leukemia Cells through Activation of the p53/miR-34a/SIRT1 Tumor Suppressor Network
Valentina Audrito et al.
CANCER RESEARCH (2011)
Sirt1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation
Ana Planavila et al.
CARDIOVASCULAR RESEARCH (2011)
Sustained Activation of mTOR Pathway in Embryonic Neural Stem Cells Leads to Development of Tuberous Sclerosis Complex-Associated Lesions
Laura Magri et al.
CELL STEM CELL (2011)
Differential gene expression pattern of diabetic rat retinas after intravitreal injection of erythropoietin
Qing Chu et al.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2011)
The Role of Erythropoietin and Erythropoiesis-Stimulating Agents in Tumor Progression
Benjamin D. Hedley et al.
CLINICAL CANCER RESEARCH (2011)
Erythropoietin Employs Cell Longevity Pathways of SIRT1 to Foster Endothelial Vascular Integrity During Oxidant Stress
Jinling Hou et al.
CURRENT NEUROVASCULAR RESEARCH (2011)
Erythropoietin and Wnt1 Govern Pathways of mTOR, Apaf-1, and XIAP in Inflammatory Microglia
Yan Chen Shang et al.
CURRENT NEUROVASCULAR RESEARCH (2011)
EPO Relies upon Novel Signaling of Wnt1 that Requires Akt1, FoxO3a,GSK-3β, and β-Catenin to Foster Vascular Integrity during Experimental Diabetes
Zhao Zhong Chong et al.
CURRENT NEUROVASCULAR RESEARCH (2011)
Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
Yu Li et al.
FASEB JOURNAL (2011)
WNT1 inducible signaling pathway protein 1 (WISP1): A novel mediator linking development and disease
Barbara Berschneider et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2011)
FoxO1 Mediates an Autofeedback Loop Regulating SIRT1 Expression
Shiqin Xiong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
Rui-Hong Wang et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Novel Avenues of Drug Discovery and Biomarkers for Diabetes Mellitus
Kenneth Maiese et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2011)
Fibronectin Potentiates Topical Erythropoietin-Induced Wound Repair in Diabetic Mice
Saher Hamed et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)
Sirt1 Overexpression in Neurons Promotes Neurite Outgrowth and Cell Survival Through Inhibition of the mTOR Signaling
Wenjing Guo et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2011)
Preclinical Efficacy Testing in Middle-Aged Rats: Nicotinamide, a Novel Neuroprotectant, Demonstrates Diminished Preclinical Efficacy after Controlled Cortical Impact
Alicia A. Swan et al.
JOURNAL OF NEUROTRAUMA (2011)
Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1
Sara Froejdoe et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2011)
The PI3K/Akt/mTOR pathway mediates retinal progenitor cell survival under hypoxic and superoxide stress
Karan P. Sanghera et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2011)
A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection
Francesca L'Episcopo et al.
MOLECULAR NEURODEGENERATION (2011)
Adult neural precursors isolated from post mortem brain yield mostly neurons: An erythropoietin-dependent process
Giovanni Marfia et al.
NEUROBIOLOGY OF DISEASE (2011)
The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy
Nagalingam R. Sundaresan et al.
SCIENCE SIGNALING (2011)
Cardiovascular Disease and mTOR Signaling
Zhao Zhong Chong et al.
TRENDS IN CARDIOVASCULAR MEDICINE (2011)
Erythropoietin prevents reactive oxygen species generation and renal tubular cell apoptosis at high glucose level
J. Dang et al.
BIOMEDICINE & PHARMACOTHERAPY (2010)
Functional erythropoietin receptor is undetectable in endothelial, cardiac, neuronal, and renal cells
Angus M. Sinclair et al.
BLOOD (2010)
Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL
S. Luo et al.
CELL DEATH AND DIFFERENTIATION (2010)
Diabetes Mellitus: Channeling Care through Cellular Discovery
Kenneth Maiese et al.
CURRENT NEUROVASCULAR RESEARCH (2010)
Early Apoptotic Vascular Signaling is Determined by Sirt1 Through Nuclear Shuttling, Forkhead Trafficking, Bad, and Mitochondrial Caspase Activation
Jinling Hou et al.
CURRENT NEUROVASCULAR RESEARCH (2010)
Roles of FoxO1 and Sirt1 in the central regulation of food intake
Tsutomu Sasaki et al.
ENDOCRINE JOURNAL (2010)
Oxidative stress: Biomarkers and novel therapeutic pathways
Kenneth Maiese et al.
EXPERIMENTAL GERONTOLOGY (2010)
Erythropoietin protects against diabetes through direct effects on pancreatic β cells
Diana Choi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis.
Darcy A. Krueger et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Mammalian target of rapamycin Hitting the bull's-eye for neurological disorders
Zhao Zhong Chong et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2010)
SIRT1 Negatively Regulates the Mammalian Target of Rapamycin
Hiyaa Singhee Ghosh et al.
PLOS ONE (2010)
Role of Nicotinamide in DNA Damage, Mutagenesis, and DNA Repair
Devita Surjana et al.
JOURNAL OF NUCLEIC ACIDS (2010)
Neuroprotective effect of herpes simplex virus-mediated gene transfer of erythropoietin in hyperglycemic dorsal root ganglion neurons
Munmun Chattopadhyay et al.
BRAIN (2009)
Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation
Aparna Purushotham et al.
CELL METABOLISM (2009)
Upregulation of the Mammalian Target of Rapamycin Complex 1 Pathway by Ras Homolog Enriched in Brain in Pancreatic β-Cells Leads to Increased β-Cell Mass and Prevention of Hyperglycemia
Suirin Hamada et al.
DIABETES (2009)
The Vitamin Nicotinamide: Translating Nutrition into Clinical Care
Kenneth Maiese et al.
MOLECULES (2009)
Erythropoietic stress and anemia in diabetes mellitus
Dhruv K. Singh et al.
NATURE REVIEWS ENDOCRINOLOGY (2009)
A FOXO in Sight: Targeting Foxo Proteins from Conception to Cancer
Kenneth Maiese et al.
MEDICINAL RESEARCH REVIEWS (2009)
Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia
Emanuela Santini et al.
SCIENCE SIGNALING (2009)
Nicotinamide overload may play a role in the development of type 2 diabetes
Shi-Sheng Zhou et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2009)
Triple play: Promoting neurovascular longevity with nicotinamide, WNT, and erythropoietin in diabetes mellitus
Kenneth Maiese
BIOMEDICINE & PHARMACOTHERAPY (2008)
Both Wnt and mTOR signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells
Jane Sun et al.
CELLULAR SIGNALLING (2008)
Enhanced tolerance against early and late apoptotic oxidative stress in mammalian neurons through nicotinamidase and sirtuin mediated pathways
Zhao Zhong Chong et al.
CURRENT NEUROVASCULAR RESEARCH (2008)
mTOR inhibition by rapamycin prevents β-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
Merav Fraenkel et al.
DIABETES (2008)
Nicotinamide induces differentiation of embryonic stem cells into insulin-secreting cells
Pilar Vaca et al.
EXPERIMENTAL CELL RESEARCH (2008)
Life span extension and neuronal cell protection by Drosophila nicotinamidase
Vitaly Balan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
DBC1 is a negative regulator of SIRT1
Ja-Eun Kim et al.
NATURE (2008)
The Wnt signaling pathway: Aging gracefully as a protectionist?
Kenneth Maiese et al.
PHARMACOLOGY & THERAPEUTICS (2008)
Exercise training promotes SIRT1 activity in aged rats
Nicola Ferrara et al.
REJUVENATION RESEARCH (2008)
Erythropoietin: Elucidating new cellular targets that broaden therapeutic strategies
Kenneth Maiese et al.
PROGRESS IN NEUROBIOLOGY (2008)
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins
Kenneth Maiese et al.
TRENDS IN MOLECULAR MEDICINE (2008)
SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B
Cheng Sun et al.
CELL METABOLISM (2007)
LRP6 mutation in a family with early coronary disease and metabolic risk factors
Arya Mani et al.
SCIENCE (2007)
Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans
Donna M. Lehman et al.
DIABETES (2007)
Nicotinamide reverses neurological and neurovascular deficits in streptozotocin diabetic rats
M. J. Stevens et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
The association of acetyl-L-carnitine and nicotinamide remits the experimental diabetes in mice by multiple low-dose streptozotocin
Juan C. Cresto et al.
PANCREAS (2006)
Polymorphisms of the low-density lipoprotein-receptor-related-protein-5 (LRP5) gene are associated with obesity phenotypes in a large family-based association study
Yan-fang Guo et al.
JOURNAL OF MEDICAL GENETICS (2006)
The interaction between heart failure and other heart diseases, renal failure, and anemia
Donald S. Silverberg et al.
SEMINARS IN NEPHROLOGY (2006)
Nicotinamide protected first-phase insulin response (FPIR) and prevented clinical disease in first-degree relatives of type-1 diabetics
PR Olmos et al.
DIABETES RESEARCH AND CLINICAL PRACTICE (2006)
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic β cells
L Bordone et al.
PLOS BIOLOGY (2006)
Cell life versus cell longevity: The mysteries surrounding the NAD(+) precursor nicotinamide
FQ Li et al.
CURRENT MEDICINAL CHEMISTRY (2006)
Nicotinamide prevents the development of hyperphosphataemia by suppressing intestinal sodium-dependent phosphate transporter in rats with adenine-induced renal failure
N Eto et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2005)
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
JT Rodgers et al.
NATURE (2005)
New avenues of exploration for erythropoietin
K Maiese et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2005)
European Nicotinamide Diabetes Intervention Trial (ENDIT):: a randomised controlled trial of intervention before the onset of type 1 diabetes
EAM Gale et al.
LANCET (2004)
Blood pressure response to erythropoietin injection in Hemodialysis and predialysis patients
K Miyashita et al.
HYPERTENSION RESEARCH (2004)
Poly(ADP-ribosyl)ation enhancement in brain cell nuclei is associated with diabetic neuropathy
T Kuchmerovska et al.
JOURNAL OF DIABETES AND ITS COMPLICATIONS (2004)
The NAD+ precursor nicotinamide governs neuronal survival during oxidative stress through protein kinase B coupled to FOXO3a and mitochondrial membrane potential
ZZ Chong et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2004)
Erythropoietin-induced hypertensive urgency in a patient with chronic renal insufficiency: Case report and review of the literature
BL Novak et al.
PHARMACOTHERAPY (2003)
Identification of differentially expressed mRNA during pancreas regeneration of rat by mRNA differential display
HW Lim et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Nicotinamide modulates mitochondrial membrane potential and cysteine protease activity during cerebral vascular endothelial cell injury
ZZ Chong et al.
JOURNAL OF VASCULAR RESEARCH (2002)
Prevention of nitric oxide-induced neuronal injury through the modulation of independent pathways of programmed cell death
SH Lin et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2000)