相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Improving Drug Candidates by Design: A Focus on Physicochemical Properties As a Means of Improving Compound Disposition and Safety
Nicholas A. Meanwell
CHEMICAL RESEARCH IN TOXICOLOGY (2011)
A Discovery Funnel for Nucleic Acid Binding Drug Candidates
Patrick A. Holt et al.
DRUG DEVELOPMENT RESEARCH (2011)
Thermodynamics of Ligand Binding and Efficiency
Charles H. Reynolds et al.
ACS MEDICINAL CHEMISTRY LETTERS (2011)
Calorimetry as a tool for understanding biomolecular interactions and an aid to drug design
John E. Ladbury
BIOCHEMICAL SOCIETY TRANSACTIONS (2010)
Higher throughput calorimetry: opportunities, approaches and challenges
Francisco E. Torres et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2010)
Thermodynamics guided lead discovery and optimization
Gyoergy G. Ferenczy et al.
DRUG DISCOVERY TODAY (2010)
Enthalpic Efficiency of Ligand Binding
Gyoergy G. Ferenczy et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2010)
A Medicinal Chemist's Guide to Molecular Interactions
Caterina Bissantz et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
THERMODYNAMICS The world is flat
Harald Schwalbe et al.
NATURE CHEMICAL BIOLOGY (2010)
Adding calorimetric data to decision making in lead discovery: a hot tip
John E. Ladbury et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Binding event measurement using a chip calorimeter coupled to magnetic beads
L. M. Ahmad et al.
SENSORS AND ACTUATORS B-CHEMICAL (2010)
Measurement of enzyme kinetics and inhibitor constants using enthalpy arrays
Michael I. Rechta et al.
ANALYTICAL BIOCHEMISTRY (2009)
A Thermodynamic Approach to the Affinity Optimization of Drug Candidates
Ernesto Freire
CHEMICAL BIOLOGY & DRUG DESIGN (2009)
Thermodynamic Optimisation in Drug Discovery: A Case Study using Carbonic Anhydrase Inhibitors
Andrew D. Scott et al.
CHEMMEDCHEM (2009)
Calorimetry and thermodynamics in drug design
Jonathan B. Chaires
ANNUAL REVIEW OF BIOPHYSICS (2008)
Chip calorimetry and its use for biochemical and cell biological investigations
Johannes Lerchner et al.
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION (2008)
Do enthalpy and entropy distinguish first in class from best in class?
Ernesto Freire
DRUG DISCOVERY TODAY (2008)
Demonstration of MEMS-based differential scanning calorimetry for determining thermodynamic properties of biomolecules
Li Wang et al.
SENSORS AND ACTUATORS B-CHEMICAL (2008)
Nano-calorimetry of small-sized biological samples
J. Lerchner et al.
THERMOCHIMICA ACTA (2008)
Microplate differential calorimetric biosensor for ascorbic acid analysis in food and pharmaceuticals
S. Vermeir et al.
ANALYTICAL CHEMISTRY (2007)
Thermodynamics of binding interactions in the rational drug design process
Geoff A. Holdgate
EXPERT OPINION ON DRUG DISCOVERY (2007)
Energetic basis of molecular recognition in a DNA aptamer
G. Reid Bishop et al.
BIOPHYSICAL CHEMISTRY (2007)
Universal screening methods and applications of ThermoFluor®
Maxwell D. Cummings et al.
JOURNAL OF BIOMOLECULAR SCREENING (2006)
A new micro-fluid chip calorimeter for biochemical applications
J Lerchner et al.
THERMOCHIMICA ACTA (2006)
Overcoming roadblocks in lead optimization: A thermodynamic perspective
AJ Ruben et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2006)
Measurements of binding thermodynamics in drug discovery
GA Holdgate et al.
DRUG DISCOVERY TODAY (2005)
Designing ligands to bind proteins
George M. Whitesides et al.
QUARTERLY REVIEWS OF BIOPHYSICS (2005)
Differential scanning calorimetry in life science: Thermodynamics, stability, molecular recognition and application in drug design
G Bruylants et al.
CURRENT MEDICINAL CHEMISTRY (2005)
Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery
MC Lo et al.
ANALYTICAL BIOCHEMISTRY (2004)
Enthalpy arrays
FE Torres et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Stabilization of proteins by ligand binding: Application to drug screening and determination of unfolding energetics
TT Waldron et al.
BIOCHEMISTRY (2003)
An autosampling differential scanning calorimeter instrument for studying molecular interactions
V Plotnikov et al.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2002)
High-density miniaturized thermal shift assays as a general strategy for drug discovery
MW Pantoliano et al.
JOURNAL OF BIOMOLECULAR SCREENING (2001)
Heat does not come in different colours:: entropy-enthalpy compensation, free energy windows, quantum confinement, pressure perturbation calorimetry, solvation and the multiple causes of heat capacity effects in biomolecular interactions
A Cooper et al.
BIOPHYSICAL CHEMISTRY (2001)
Structure-based drug design
CM Henry
CHEMICAL & ENGINEERING NEWS (2001)
Measurement and analysis of results obtained on biological substances with differential scanning calorimetry
HJ Hinz et al.
PURE AND APPLIED CHEMISTRY (2001)
Entropy-enthalpy compensation: Fact or artifact?
K Sharp
PROTEIN SCIENCE (2001)
Energetics bf DNA intercalation reactions
JS Ren et al.
BIOCHEMISTRY (2000)
A high-throughput silicon microphysiometer
K Verhaegen et al.
SENSORS AND ACTUATORS A-PHYSICAL (2000)