相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Development of inductively coupled plasma-mass spectrometry-based protease assays
Urja S. Lathia et al.
ANALYTICAL BIOCHEMISTRY (2010)
Mammalian Sirtuins: Biological Insights and Disease Relevance
Marcia C. Haigis et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)
SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1
Michelle Pacholec et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Quantitative Analyses of Aggregation, Autofluorescence, and Reactivity Artifacts in a Screen for Inhibitors of a Thiol Protease
Ajit Jadhav et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
MULTIPLE SCLEROSIS Closing in on an oral treatment
Roland Martin
NATURE (2010)
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors
Jianming Zhang et al.
NATURE (2010)
Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor
Christopher J. Duff et al.
BIOCHEMICAL JOURNAL (2009)
The biochemical pharmacology of renin inhibitors: Implications for translational medicine in hypertension, diabetic nephropathy and heart failure: Expectations and reality
Zaid Abassi et al.
BIOCHEMICAL PHARMACOLOGY (2009)
Binding to the Low-Density Lipoprotein Receptor Accelerates Futile Catalytic Cycling in PCSK9 and Raises the Equilibrium Level of Intramolecular Acylenzyme
Kieran F. Geoghegan et al.
BIOCHEMISTRY (2009)
Processing of peptide and hormone precursors at the dibasic cleavage sites
Mohamed Rholam et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2009)
Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity
Dirk Beher et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2009)
Saquinavir, the pioneer antiretroviral protease inhibitor
Charles J. L. la Porte
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2009)
Structural and Biochemical Characterization of the Wild Type PCSK9-EGF(AB) Complex and Natural Familial Hypercholesterolemia Mutants
Matthew J. Bottomley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
A 100K well screen for a muscarinic receptor using the Epic (R) label-free system - a reflection on the benefits of the label-free approach to screening seven-transmembrane receptors
K. Dodgson et al.
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2009)
Fas-Mediated Apoptosis Is Regulated by the Extracellular Matrix Protein CCN1 (CYR61) In Vitro and In Vivo
Vladislava Juric et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Pharmaceutical R&D: the road to positive returns
Eric David et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Lessons from 60 years of pharmaceutical innovation
Bernard Munos
NATURE REVIEWS DRUG DISCOVERY (2009)
Peptide processing and biology in human disease
Suzana Kovac et al.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2009)
A specific mechanism for nonspecific activation in reporter-gene assays
Douglas S. Auld et al.
ACS CHEMICAL BIOLOGY (2008)
Bright ideas for chemical biology
Luke D. Lavis et al.
ACS CHEMICAL BIOLOGY (2008)
Fluorescence polarization immunoassays and related methods for simple, high-throughput screening of small molecules
David S. Smith et al.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2008)
Mechanisms and Molecular Probes of Sirtuins
Brian C. Smith et al.
CHEMISTRY & BIOLOGY (2008)
The activation and physiological functions of the proprotein convertases
Nabil G. Seidah et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2008)
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Jill C. Milne et al.
NATURE (2007)
Mass spectrometric techniques for label-free high-throughput screening in drug discovery
Thomas P. Roddy et al.
ANALYTICAL CHEMISTRY (2007)
A high-throughput screen for aggregation-based inhibition in a large compound library
Brian Y. Feng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia
David Cunningham et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
Renin inhibitors: novel agents for renoprotection or a better angiotensin receptor blocker for blood pressure lowering?
Matthew R. Weir
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2007)
Opinion - How many drug targets are there?
John P. Overington et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
A broad-spectrum fluorescence-based peptide library for the rapid identification of protease substrates
DA Thomas et al.
PROTEOMICS (2006)
Mechanism of the maturation process of SARS-CoV 3CL protease
MF Hsu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Discovery and preclinical profile of saxagliptin (BMS-477118): A highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
DJ Augeri et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
SIR2:: The biochemical mechanism of NAD+-dependent protein deacetylation and ADP-ribosyl enzyme intermediates
AA Sauve et al.
CURRENT MEDICINAL CHEMISTRY (2004)
Inhibitors of dipeptidyl peptidase IV:: a novel approach for the prevention and treatment of Type 2 diabetes?
CF Deacon et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2004)
Navigating chemical space for biology and medicine
C Lipinski et al.
NATURE (2004)
Fluorescent probes for proteolysis: Tools for drug discovery
J Neefjes et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
Fluorescence readouts in HTS: no gain without pain?
P Gribbon et al.
DRUG DISCOVERY TODAY (2003)
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
KT Howitz et al.
NATURE (2003)
Hit and lead generation:: Beyond high-throughput screening
KH Bleicher et al.
NATURE REVIEWS DRUG DISCOVERY (2003)
Functional characterization of Narc 1, a novel proteinase related to proteinase K
S Naureckiene et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2003)
Drugs targeting the renin-angiotensin-aldosterone system
MA Zaman et al.
NATURE REVIEWS DRUG DISCOVERY (2002)
Enzyme kinetics determined using calorimetry: A general assay for enzyme activity?
MJ Todd et al.
ANALYTICAL BIOCHEMISTRY (2001)
Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries
JL Harris et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)