4.5 Review

Exemplification of the challenges associated with utilising fluorescence intensity based assays in discovery

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemical Research Methods

Development of inductively coupled plasma-mass spectrometry-based protease assays

Urja S. Lathia et al.

ANALYTICAL BIOCHEMISTRY (2010)

Review Pathology

Mammalian Sirtuins: Biological Insights and Disease Relevance

Marcia C. Haigis et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

Article Biochemistry & Molecular Biology

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

Michelle Pacholec et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Editorial Material Multidisciplinary Sciences

MULTIPLE SCLEROSIS Closing in on an oral treatment

Roland Martin

NATURE (2010)

Article Multidisciplinary Sciences

Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors

Jianming Zhang et al.

NATURE (2010)

Article Biochemistry & Molecular Biology

Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor

Christopher J. Duff et al.

BIOCHEMICAL JOURNAL (2009)

Review Biochemistry & Molecular Biology

Processing of peptide and hormone precursors at the dibasic cleavage sites

Mohamed Rholam et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2009)

Article Biochemistry & Molecular Biology

Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity

Dirk Beher et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2009)

Review Biochemistry & Molecular Biology

Saquinavir, the pioneer antiretroviral protease inhibitor

Charles J. L. la Porte

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2009)

Article Biochemistry & Molecular Biology

Structural and Biochemical Characterization of the Wild Type PCSK9-EGF(AB) Complex and Natural Familial Hypercholesterolemia Mutants

Matthew J. Bottomley et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Fas-Mediated Apoptosis Is Regulated by the Extracellular Matrix Protein CCN1 (CYR61) In Vitro and In Vivo

Vladislava Juric et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

News Item Biotechnology & Applied Microbiology

Pharmaceutical R&D: the road to positive returns

Eric David et al.

NATURE REVIEWS DRUG DISCOVERY (2009)

Article Biotechnology & Applied Microbiology

Lessons from 60 years of pharmaceutical innovation

Bernard Munos

NATURE REVIEWS DRUG DISCOVERY (2009)

Article Endocrinology & Metabolism

Peptide processing and biology in human disease

Suzana Kovac et al.

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2009)

Article Biochemistry & Molecular Biology

A specific mechanism for nonspecific activation in reporter-gene assays

Douglas S. Auld et al.

ACS CHEMICAL BIOLOGY (2008)

Review Biochemistry & Molecular Biology

Bright ideas for chemical biology

Luke D. Lavis et al.

ACS CHEMICAL BIOLOGY (2008)

Review Biochemical Research Methods

Fluorescence polarization immunoassays and related methods for simple, high-throughput screening of small molecules

David S. Smith et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2008)

Review Biochemistry & Molecular Biology

Mechanisms and Molecular Probes of Sirtuins

Brian C. Smith et al.

CHEMISTRY & BIOLOGY (2008)

Review Biochemistry & Molecular Biology

The activation and physiological functions of the proprotein convertases

Nabil G. Seidah et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2008)

Article Chemistry, Analytical

Mass spectrometric techniques for label-free high-throughput screening in drug discovery

Thomas P. Roddy et al.

ANALYTICAL CHEMISTRY (2007)

Article Chemistry, Medicinal

A high-throughput screen for aggregation-based inhibition in a large compound library

Brian Y. Feng et al.

JOURNAL OF MEDICINAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia

David Cunningham et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)

Review Urology & Nephrology

Renin inhibitors: novel agents for renoprotection or a better angiotensin receptor blocker for blood pressure lowering?

Matthew R. Weir

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2007)

Article Biotechnology & Applied Microbiology

Opinion - How many drug targets are there?

John P. Overington et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Article Biochemistry & Molecular Biology

Mechanism of the maturation process of SARS-CoV 3CL protease

MF Hsu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Review Biochemistry & Molecular Biology

SIR2:: The biochemical mechanism of NAD+-dependent protein deacetylation and ADP-ribosyl enzyme intermediates

AA Sauve et al.

CURRENT MEDICINAL CHEMISTRY (2004)

Review Pharmacology & Pharmacy

Inhibitors of dipeptidyl peptidase IV:: a novel approach for the prevention and treatment of Type 2 diabetes?

CF Deacon et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2004)

Article Multidisciplinary Sciences

Navigating chemical space for biology and medicine

C Lipinski et al.

NATURE (2004)

Review Biotechnology & Applied Microbiology

Fluorescent probes for proteolysis: Tools for drug discovery

J Neefjes et al.

NATURE REVIEWS DRUG DISCOVERY (2004)

Review Pharmacology & Pharmacy

Fluorescence readouts in HTS: no gain without pain?

P Gribbon et al.

DRUG DISCOVERY TODAY (2003)

Article Multidisciplinary Sciences

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

KT Howitz et al.

NATURE (2003)

Review Biotechnology & Applied Microbiology

Hit and lead generation:: Beyond high-throughput screening

KH Bleicher et al.

NATURE REVIEWS DRUG DISCOVERY (2003)

Article Biochemistry & Molecular Biology

Functional characterization of Narc 1, a novel proteinase related to proteinase K

S Naureckiene et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2003)

Review Biotechnology & Applied Microbiology

Drugs targeting the renin-angiotensin-aldosterone system

MA Zaman et al.

NATURE REVIEWS DRUG DISCOVERY (2002)

Article Biochemical Research Methods

Enzyme kinetics determined using calorimetry: A general assay for enzyme activity?

MJ Todd et al.

ANALYTICAL BIOCHEMISTRY (2001)

Review Multidisciplinary Sciences

Oncogenic kinase signalling

P Blume-Jensen et al.

NATURE (2001)

Article Multidisciplinary Sciences

Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries

JL Harris et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)