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Phase I/II adenoviral p53 gene therapy for chemoradiation resistant advanced esophageal squamous cell carcinoma
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CANCER SCIENCE (2006)
Activation and cross-talk between Akt, NF-κB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Cell cycle arrest and apoptotic induction in LNCaP cells by MCS-C2, novel cyclin-dependent kinase inhibitor, through p53/p21WAF1/CIP1 pathway
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CANCER SCIENCE (2006)
Ubiquitin ligases: cell-cycle control and cancer
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NATURE REVIEWS CANCER (2006)
Norepinephrine-induced oxidative stress causes PC-12 cell apoptosis by both endoplasmic reticulum stress and mitochondrial intrinsic pathway: inhibition of phosphatidylinositol 3-kinase survival pathway
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AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)
Diclofenac, a non-steroidal anti-inflammatory drug, suppresses apoptosis induced by endoplasmic reticulum stresses by inhibiting caspase signaling
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NEUROPHARMACOLOGY (2006)
E2F1-induced apoptosis:: turning killers into therapeutics
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TRENDS IN MOLECULAR MEDICINE (2006)
Low p53 expression of acute myelocytic leukemia cells with t(8;21) chromosome abnormality:: Association with low p14ARF expression
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LEUKEMIA RESEARCH (2006)
Biotin supplementation decreases the expression of the SERCA3 gene (ATP2A3) in Jurkat cells, thus, triggering unfolded protein response
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JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2006)
An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors
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NATURE CHEMICAL BIOLOGY (2006)
3,3′-Diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5
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CARCINOGENESIS (2006)
Endoplasmic reticulum stress-induced apoptosis - Multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Levels of HdmX expression dictate the sensitivity of normal and transformed cells to nutlin-3
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CANCER RESEARCH (2006)
From acute ER stress to physiological roles of the Unfolded Protein Response
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CELL DEATH AND DIFFERENTIATION (2006)
Coupling endoplasmic reticulum stress to the cell-death program: a novel HSP90-independent role for the small chaperone protein p23
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CELL DEATH AND DIFFERENTIATION (2006)
Cellular response to endoplasmic reticulum stress: a matter of life or death
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CELL DEATH AND DIFFERENTIATION (2006)
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: Implications for therapy
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
p53 ubiquitination: Mdm2 and beyond
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MOLECULAR CELL (2006)
Mdm2-mediated pRB downregulation is involved in carcinogenesis in a p53-independent manner
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Radiosensitization of lung cancer by nutlin, an inhibitor of murine double minute 2
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MOLECULAR CANCER THERAPEUTICS (2006)
Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells
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CANCER RESEARCH (2006)
Stress induction of GRP78/BiP and its role in cancer
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CURRENT MOLECULAR MEDICINE (2006)
A twist for survival and cancer progression
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BRITISH JOURNAL OF CANCER (2006)
The p53/Mdm2/p14ARF cell cycle control pathway genes may be inactivated by genetic and epigenetic mechanisms in gliomas
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CANCER GENETICS AND CYTOGENETICS (2006)
Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis
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CANCER RESEARCH (2005)
Altering protein turnover in tumor cells: New opportunities for anti-cancer therapies
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DRUG RESISTANCE UPDATES (2005)
Nongenotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma
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BLOOD (2005)
Endoplasmic reticulum stress: cell life and death decisions
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JOURNAL OF CLINICAL INVESTIGATION (2005)
Endoplasmic reticulum stress compromises the ubiquitin-proteasome system
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HUMAN MOLECULAR GENETICS (2005)
Suppression of p53 by Notch in lymphomagenesis: Implications for initiation and regression
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CANCER RESEARCH (2005)
Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models
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CANCER CHEMOTHERAPY AND PHARMACOLOGY (2005)
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JOURNAL OF CLINICAL ONCOLOGY (2005)
Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance
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LUNG CANCER (2005)
ARF-BP1/mule is a critical mediator of the ARF tumor suppressor
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CELL (2005)
Phase I pharmacokinetic and pharmacodynarnic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies
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JOURNAL OF CLINICAL ONCOLOGY (2005)
Fenretinide: A p53-independent way to kill cancer cells
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
C-Abl as a modulator of p53
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Kringle 5 of human plasminogen induces apoptosis of endothelial and tumor cells through surface-expressed glucose-regulated protein 78
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CANCER RESEARCH (2005)
Quantitative measurement of events in the mammalian unfolded protein response
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METHODS (2005)
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CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2005)
Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors
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JOURNAL OF CLINICAL ONCOLOGY (2005)
Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3
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BLOOD (2005)
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CURRENT CANCER DRUG TARGETS (2005)
Overview of cell death signaling pathways
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CANCER BIOLOGY & THERAPY (2005)
Proteasome inhibition as a novel therapeutic target in human cancer
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JOURNAL OF CLINICAL ONCOLOGY (2005)
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MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2005)
Message in a bottle: Role of the 70-kDa heat shock protein family in anti-tumor immunity
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EUROPEAN JOURNAL OF IMMUNOLOGY (2005)
c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanism
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ONCOGENE (2004)
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CELL DEATH AND DIFFERENTIATION (2004)
17-(Allylamino)-17-demethoxygeldanamycin activity in human melanoma models
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ANTI-CANCER DRUGS (2004)
Regulation of apoptosis proteins in cancer cells by ubiquitin
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ONCOGENE (2004)
Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy - A comprehensive review
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PHARMACOLOGY & THERAPEUTICS (2004)
Altered states: selectively drugging the Hsp90 cancer chaperone
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TRENDS IN MOLECULAR MEDICINE (2004)
Effect on tumor cells of blocking survival response to glucose deprivation
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JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2004)
Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands
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CANCER CELL (2004)
Cell cycle-related signaling pathways modulated by peripheral benzodiazepine receptor ligands in colorectal cancer cells
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response
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NATURE CELL BIOLOGY (2004)
A trip to the ER: coping with stress
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TRENDS IN CELL BIOLOGY (2004)
Molecular analysis of p53, MDM2 and H-ras genes in low-grade central osteosarcoma
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PATHOLOGY RESEARCH AND PRACTICE (2004)
Growth and DNA damage-inducible transcription factor 153 mediates apoptosis in response to fenretinide but not synergy between fenretinide and chemotherapeutic drugs in neuroblastoma
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MOLECULAR PHARMACOLOGY (2003)
Small molecules that reactivate mutant p53
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EUROPEAN JOURNAL OF CANCER (2003)
Proteasome inhibitors disrupt the unfolded protein response in myeloma cells
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Gene expression during ER stress-induced apoptosis in neurons:: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway
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JOURNAL OF CELL BIOLOGY (2003)
Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis
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JOURNAL OF HEPATOLOGY (2003)
Potential new therapeutics for Waldenstrom's macroglobulinemia
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SEMINARS IN ONCOLOGY (2003)
Heat shock protein 90 as a molecular target for cancer therapeutics
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CANCER CELL (2003)
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
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MOLECULAR CELL (2003)
Human papillomavirus-induced carcinogenesis and the ubiquitin-proteasome system
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SEMINARS IN CANCER BIOLOGY (2003)
Ubiquitin-dependent proteolysis: its role in human diseases and the design of therapeutic strategies
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MOLECULAR GENETICS AND METABOLISM (2002)
ER-associated degradation in protein quality control and cellular regulation
RY Hampton
CURRENT OPINION IN CELL BIOLOGY (2002)
Proteasome inhibitors: from research tools to drug candidates
AF Kisselev et al.
CHEMISTRY & BIOLOGY (2001)
The sarco/endoplasmic reticulum calcium-ATPase 2b is an endoplasmic reticulum stress-inducible protein
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JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
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