期刊
EXPERT OPINION ON DRUG DISCOVERY
卷 4, 期 4, 页码 357-372出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/17460440902794912
关键词
arrhythmias; cardiomyocytes; drug discovery; electrophysiology; safety pharmacology; stem cells
资金
- Technology Foundation [UGT.6746]
- Netherlands Organization for Scientific Research (NWO) [916.36.012]
- VIDI [016-056-319]
Background: The pharmaceutical industry suffers from high attrition rates during late phases of drug development. Improved models for early evaluation of drug efficacy and safety are needed to address this problem. Recent developments have illustrated that human stem cell-derived cardiomyocytes are attractive for using as a model system for different cardiac diseases and as a model for screening, safety pharmacology and toxicology. Objective: In this review, we discuss contemporary drug discovery models and their characteristics for cardiac efficacy testing and safety assessment. Additionally, we evaluate various sources of stem cells and how these cells could potentially improve early screening and safety models. Conclusion: We conclude that human stem cells offer a source of physiologically relevant cells that show great potential as a future tool in cardiac drug discovery. However, some technical challenges related to cell differentiation and production and also to validation of improved platforms remain and must be overcome before successful application can become a reality.
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