期刊
EXPERT OPINION ON DRUG DISCOVERY
卷 4, 期 1, 页码 71-84出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/13543770802630455
关键词
amyloid; neurodegenerative diseases; protein misfolding; therapy
资金
- NIH [AG02881]
- Mitchell Foundation
Background: Neurodegenerative diseases are a group of chronic and progressive disorders of the nervous system. A hallmark event in these diseases is the misfolding and accumulation in the brain of protein aggregates. Objective: In this article, we describe the knowledge of the mechanism of protein misfolding and aggregation, its role in neurodegeneration and the diverse therapeutic targets for intervention. We also critically review various strategies under development to discover drugs attacking this process. Conclusion: in spite of the substantial progress on understanding the critical role of protein misfolding and aggregation, drugs effective against this process are still years away from approval.
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