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K. Linke et al.
CELL DEATH AND DIFFERENTIATION (2008)
Isoquinolin-1-one inhibitors of the MDM2-p53 interaction
Ulli Rothweiler et al.
CHEMMEDCHEM (2008)
Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2
Mu-Shui Dai et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Mdm2 promotes genetic instability and transformation independent of p53
Alyssa Bouska et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Mdm2 and Mdm4 loss regulates distinct p53 activities
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MOLECULAR CANCER RESEARCH (2008)
Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer
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Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells
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Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function
L. M. S. Lau et al.
ONCOGENE (2008)
The Wip1 phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop
Xiongbin Lu et al.
CANCER CELL (2007)
Targeted inactivation of mdm2 RING finger e3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation
Koji Itahana et al.
CANCER CELL (2007)
Selection for mutations in the cDNAs of transgenic mice upon expression of an embryonic lethal protein
Katja Schuster et al.
TRANSGENIC RESEARCH (2007)
Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2
Laetitia K. Linares et al.
NATURE CELL BIOLOGY (2007)
Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation
Mikael S. Lindstrom et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1α and Hdm2
Gretchen A. LaRusch et al.
CANCER RESEARCH (2007)
HDM2-binding partners: Interaction with translation elongation factor EF1 alpha
Rebecca Frum et al.
JOURNAL OF PROTEOME RESEARCH (2007)
Targeting protein-protein interactions: Lessons from p53/MDM2
Justin K. Murray et al.
BIOPOLYMERS (2007)
Mdm2 targets the p53 transcription cofactor JMY for degradation
Amanda S. Coutts et al.
EMBO REPORTS (2007)
Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53
Milka Kostic et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold
Ian R. Hardcastle et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
c-Abl phosphorylates Hdm2 at tyrosine 276 in response to DNA damage and regulates interaction with ARF
S. S. Dias et al.
ONCOGENE (2006)
Binding of p53 to the central domain of Mdm2 is regulated by phosphorylation
Roman Kulikov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Mechanistic insights into maintenance of high p53 acetylation by PTEN
Andrew G. Li et al.
MOLECULAR CELL (2006)
Hdm2 nuclear export, regulated by insulin-like growth factor-I/MAPK/p90Rsk signaling, mediates the transformation of human cells
Mark W. Jackson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction
Ke Ding et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner
Gareth L. Bond et al.
CANCER RESEARCH (2006)
p53 stabilization and transactivation by a von Hippel-Lindau protein
Jae-Seok Roe et al.
MOLECULAR CELL (2006)
Benzodiazepinedione inhibitors of the Hdm2 : p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo
HK Koblish et al.
MOLECULAR CANCER THERAPEUTICS (2006)
Hexylitaconic acid: A new inhibitor of p53-HDM2 interaction isolated from a marine-derived fungus, Arthrinium sp.
S Tsukamoto et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway
Z Zhang et al.
ONCOGENE (2005)
NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro
M Krajewski et al.
NATURE MEDICINE (2005)
Monitoring the effects of antagonists on protein-protein interactions with NMR spectroscopy
L D'Silva et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Mdm2 and HIF-1α interaction in tumor cells during hypoxia
AL Nieminen et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2005)
Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified
LD Mayo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53
H Higashitsuji et al.
CANCER CELL (2005)
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
YL Yang et al.
CANCER CELL (2005)
Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair
JR Alt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
HDM2 phosphorylation by MAPKAP kinase 2
HO Weber et al.
ONCOGENE (2005)
Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction
IR Hardcastle et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
BL Grasberger et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
MDM2 and human malignancies: Expression, clinical pathology, prognostic markers, and implications for chemotherapy
E Rayburn et al.
CURRENT CANCER DRUG TARGETS (2005)
The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma
A Slack et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation
CH Uchida et al.
EMBO JOURNAL (2005)
Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation
S Kurki et al.
CANCER CELL (2004)
Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation
JM Stommel et al.
EMBO JOURNAL (2004)
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
LT Vassilev et al.
SCIENCE (2004)
NMR structure of a complex between MDM2 and a small molecule inhibitor
DC Fry et al.
JOURNAL OF BIOMOLECULAR NMR (2004)
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition
MS Dai et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
A nonpeptidic sulfonamide inhibits the p53-mdm2 interaction and activates p53-dependent transcription in mdm2-overexpressing cells
PS Galatin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth
P Sdek et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis
T Thompson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
PML regulates p53 stability by sequestering Mdm2 to the nucleolus
R Bernardi et al.
NATURE CELL BIOLOGY (2004)
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
N Issaeva et al.
NATURE MEDICINE (2004)
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
GL Bond et al.
CELL (2004)
The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression
N Minsky et al.
MOLECULAR CELL (2004)
Cul4A physically associates with MDM2 and participates in the proteolysis of p53
A Nag et al.
CANCER RESEARCH (2004)
Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5
MS Dai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
DNA damage-induced MDMX degradation is mediated by MDM2
H Kawai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2
P de Graaf et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation
I Louria-Hayon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Physical and functional interactions between PML and MDM2
XL Wei et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Critical role for a central part of Mdm2 in the ubiquitylation of p53
E Meulmeester et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Regulation of HDM2 activity by the ribosomal protein L11
MAE Lohrum et al.
CANCER CELL (2003)
Stimulation of human DNA polymerase ε by MDM2
H Asahara et al.
NUCLEIC ACIDS RESEARCH (2003)
Direct interactions between HIF-1α and Mdm2 modulate p53 function
DL Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
mdm2 is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation
SM Mendrysa et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway
YP Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Binding of an inhibitor of the p53/MDM2 interaction to MDM2
SJ Duncan et al.
CHEMICAL COMMUNICATIONS (2003)
Transformation of normal human cells in the absence of telomerase activation
YR Seger et al.
CANCER CELL (2002)
The initial evaluation of non-peptidic small-molecule HDM2 inhibitors based on p53-HDM2 complex structure
JH Zhao et al.
CANCER LETTERS (2002)
MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation
YT Jin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation
Z Goldberg et al.
EMBO JOURNAL (2002)
Phosphorylation of HDM2 by Akt
M Ashcroft et al.
ONCOGENE (2002)
PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy
LD Mayo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation
D Migliorini et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
BHP Zhou et al.
NATURE CELL BIOLOGY (2001)
Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms
R Stad et al.
EMBO REPORTS (2001)
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
LD Mayo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
J Parant et al.
NATURE GENETICS (2001)
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
R Maya et al.
GENES & DEVELOPMENT (2001)
Isolation and structure elucidation of chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp.
SJ Duncan et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53
R Stoll et al.
BIOCHEMISTRY (2001)
MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins
E Kobet et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Opposing effects of Ras on p53:: Transcriptional activation of mdm2 and induction of p19ARF
S Ries et al.
CELL (2000)
p53AlP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
K Oda et al.
CELL (2000)
Stress signals utilize multiple pathways to stabilize p53
M Ashcroft et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
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