期刊
EXPERT OPINION ON DRUG DELIVERY
卷 11, 期 5, 页码 753-766出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/17425247.2014.897326
关键词
colon delivery; controlled release; guar gum; oral route; therapeutics
资金
- Indian Council of Medical Research [64/ 4/ 2011-BMS]
- IRIS, New Delhi, India [2010-08710]
Introduction: The past decade of research has witnessed a huge advancement in research efforts on guar gum (GG)-based polymers as controlled release (CR) formulations for the delivery of therapeutics. Areas covered: The unique structure and beneficial properties of GG makes it an attractive biomaterial in CR applications. Current status on GG-based polymers has been addressed as a CR formulation in the form of microspheres, nanoparticles, hydrogels and matrix tablets for the delivery of various types of therapeutics having a wide range of physicochemical properties. Majority of literature on GG as a platform technology has dealt with oral route of drug administration as it is the most convenient, patient-compliant and preferred approach. Recent reports on GG-based polymers are summarized and critically discussed to narrate their usefulness as oral delivery systems. Expert opinion: The research on GG-based formulations has been focused on optimization of the therapy by designing CR dosage forms with a minimum number of excipients. In this context, GG-based polymers are quite attractive. The present review summarizes published reports on these systems and offers expert opinion relevant to oral delivery of therapeutics.
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