期刊
EXPERT OPINION ON DRUG DELIVERY
卷 8, 期 8, 页码 991-1007出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/17425247.2011.581656
关键词
cancer therapy; drug delivery; thermosensitive hydrogel; tissue regeneration
资金
- National Science Foundation [DMR1006734]
- Institute for Materials Research at the Ohio State University
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1006734] Funding Source: National Science Foundation
Introduction: Controlled drug delivery has been widely applied in areas such as cancer therapy and tissue regeneration. Thermosensitive hydrogel-based drug delivery systems have increasingly attracted the attention of the drug delivery community, as the drugs can be readily encapsulated and released by the hydrogels. Areas covered: Thermosensitive hydrogels that can serve as drug carriers are discussed in this paper. Strategies used to control hydrogel properties, in order to tailor drug release kinetics, are also reviewed. This paper also introduces applications of the thermosensitive hydrogel-based drug delivery systems in cancer therapy and tissue regeneration. Expert opinion: When designing a drug delivery system using thermosensitive hydrogels, one needs to consider what type of thermosensitive hydrogel needs to be used, and how to manipulate its properties to meet the desired drug release kinetics. For material selection, both naturally derived and synthetic thermosensitive polymers can be used. Various methods can be used to tailor thermosensitive hydrogel properties in order to achieve the desired drug release profile.
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