期刊
EXPERT OPINION ON DRUG DELIVERY
卷 8, 期 7, 页码 965-972出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/17425247.2011.588206
关键词
drug delivery; electrostatic particle collector; nano spray dryer; nanoparticles and microparticles; powder; spray drying; vibrating mesh spray technology
资金
- Science and Engineering Research Council of A*STAR (Agency for Science, Technology and Research), Singapore [ICES/09-122A02]
Introduction: Spray drying is an extremely well-established technology for the production of micro-particulate powders suited for a variety of drug delivery applications. In recent years, the rise in nanomedicine has placed increased pressure on the existing systems to produce nanoparticles in good yield and with a narrow size distribution. However, the separation and collection of nanoparticles with conventional spray dryer set ups is extremely challenging due to their typical low collection efficiency for fine particles <2 mu m. Currently, nanoparticles have to be agglomerated into larger microparticles, via a two-step approach, in order to collect them in a sizeable amount. However, this method has to contend with the issue of adequate redispersibility of the primary particles to reap the full benefits of nanosizing. Areas covered: An overview on the advances in spray drying technology is provided in this review with particular emphasis on the novel Buchi (R) Nano Spray Dryer B-90. Readers will appreciate the limitations of conventional spray drying technology, understand the mechanisms of the Buchi (R) Nano Spray Dryer B-90, and also learn about the strengths and shortcomings of the system. Expert opinion: The Buchi (R) Nano Spray Dryer B-90 offers a new, simple and alternative approach for the production of nanoparticles suited for a variety of drug delivery applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据