期刊
EXPERT OPINION ON DRUG DELIVERY
卷 7, 期 5, 页码 577-587出版社
INFORMA HEALTHCARE
DOI: 10.1517/17425240903571614
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资金
- NIH [5DP1OD000798]
- David and Lucile Packard Foundation
- Harvard University
- NSF [ECS-0335765]
- Washington University in St Louis
- Washington University Molecular Imaging Center
- Alvin J Siteman Cancer Center at Barnes-Jewish Hospital
- Washington University School of Medicine
- National Cancer Institute [P30 CA91842]
- Alafi Neuroimaging Laboratory
- Hope Center for Neurological Disorders
- NIH Neuroscience Blueprint Center [P30 NS057105]
- NATIONAL CANCER INSTITUTE [P30CA091842] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P30NS057105] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP1OD000798] Funding Source: NIH RePORTER
Areas covered in this review: This review discusses the use of gold nanocages, a new class of plasmonic nanoparticles, for photothermal applications. Gold nanocages are hollow, porous structures with compact sizes and precisely controlled plasmonic properties and surface chemistry. Also, a recent study of gold nanocages as drug-release carriers by externally controlling the opening and closing of the pores with a smart polymer whose conformation changes at a specific temperature is discussed. Release of the contents can be initiated remotely through near-infrared irradiation. Together, these topics cover the years from 2002 to 2009. What the reader will gain: The reader will be exposed to different aspects of gold nanocages, including synthesis, surface modification, in vitro studies, intial in vivo data and perspectives on future studies. Take home message: Gold nanocages are a promising platform for cancer therapy in terms of both photothermal destruction and drug delivery.
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