期刊
EXPERT OPINION ON BIOLOGICAL THERAPY
卷 14, 期 7, 页码 905-916出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.2014.900537
关键词
adoptive immunotherapy; cytokine-induced killer cells; dendritic cells; NKT cells; solid tumors
Introduction: Cytokine-induced killer (CIK) cells are mainly CD3(+) CD56(+) NKT cells exhibiting non-MHC-restricted cytotoxicity against a broad range of tumors. Much research is going on to improve CIK cell effectivity and to evaluate the clinical benefit of different combinations with conventional therapies. Areas covered: This review provides an update on in vitro/in vivo studies and clinical trials applying CIK cells for the treatment of solid tumors. This comprises attempts using additional cytokines, genetic engineering and combinations with different conventional and modern therapies. Expert opinion: Since our last review, much effort has been made to improve CIK cell cytotoxicity and clinical effectivity. Targeted CIK cell therapy and combinations of CIK cells with antiangiogenic drugs or oncolytic viruses are examples of recent outstanding achievements in the field of adoptive CIK cell therapy. The clinical application of CIK cells in combination with conventional therapies, especially, obtained promising results. However, the best combination and the optimal therapy schedule have yet to be defined.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据